High-dose methotrexate in combination with interferons in the treatment of malignant pleural mesothelioma

British Journal of Cancer

Volumn 80, Issue 11, 1999, Pages 1781-1785

  Halme, M ^a   Knuuttila, A ^a   Vehmas, T ^b   Tammilehto, L ^c   Mantyla M ^b   Salo, J ^b   Mattson, K ^a  

^a Div Pulmon Dis Clin Physiol   (Finland)

^b HELSINKI UNIVERSITY CENTRAL HOSPITAL   (Finland)

^c FINNISH INSTITUTE OF OCCUPATIONAL HEALTH   (Finland)

Author keywords

High dose MTX; IFN ; IFN ; Pleural mesothelioma

Indexed keywords

ALPHAN1 INTERFERON; ANTREX; FOLINATE CALCIUM; METHOTREXATE; NALTREXONE; RECOMBINANT GAMMA INTERFERON; UNCLASSIFIED DRUG;

ADULT; AGED; ANEMIA; ARTICLE; CANCER COMBINATION CHEMOTHERAPY; CANCER IMMUNOTHERAPY; CANCER SURVIVAL; CLINICAL TRIAL; FEMALE; GASTROINTESTINAL TOXICITY; HUMAN; INTRAVENOUS DRUG ADMINISTRATION; LEUKOPENIA; MAINTENANCE THERAPY; MALE; NEPHROTOXICITY; NEUROTOXICITY; ORAL DRUG ADMINISTRATION; PLEURA MESOTHELIOMA; PRIORITY JOURNAL; SKIN TOXICITY; SUBCUTANEOUS DRUG ADMINISTRATION; THROMBOCYTOPENIA;

ADOLESCENT; ADULT; AGED; ANTIMETABOLITES, ANTINEOPLASTIC; COMBINED MODALITY THERAPY; FEMALE; HUMANS; INTERFERON-ALPHA; MALE; MESOTHELIOMA; METHOTREXATE; MIDDLE AGED; NEOPLASM STAGING; PLEURAL NEOPLASMS; SURVIVAL ANALYSIS;

EID: 0032767688     PISSN: 00070920     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjc.6690597     Document Type: Article

References (23)

1. Ardizzoni A, Pennucci MC, Castagneto B, Mariani GL, Cinquegrana A, Magri D, Verna A, Salvali F and Rosso R (1994) Recombinant interferon alpha-2b in the treatment of diffuse malignant pleural mesothelioma. Am J Clin Oncol (CCT) 17: 80-82
2. Boutin C, Nussbaum E, Monnet I, Bignon J, Vanderschueren R, Guerin J-C, Menard O, Mignot P, Dabouis and Douillard J-V (1994) Intrapleural treatment with recombinant gamma-interferon in early stage malignant pleural mesothelioma. Cancer 74: 2460-2467
3. Christmas TI, Manning LS, Garlepp MJ, Musk AW and Robinson BW (1993) Effect of interferon-alpha 2a on malignant mesothelioma. J Interferon Res 13: 9-12
4. Dimitrov NV, Egner J, Balcueva E and Suhrland LG (1982) High-dose methotrexate with citrovorum factor and vincristine in the treatment of malignant mesothelioma. Cancer 50: 1245-1247
5. Dirix LY, van Meerbeeck J, Schrijvers D, Corthouts B, Prove A, van Marck E, Vermeire P and van Oosterom AT (1994) A phase II trial of dose-escalated doxorubicin and ifosfamide/mesna in patients with malignant mesothelioma. Ann Oncol 5: 653-655
6. Hand AM, Husgafvel-Purstamen K, Tammilehto L, Mattson K and Linnainmaa K (1991) Malignant mesothelioma: the antiproliferative effect of cytokine combinations on three human mesotelioma cell lines. Cancer Lett 58: 205-210
7. Hand AM, Pelin K, Mattson K and Linnainmaa K (1995) Interferon (IFN)-α and IFN-γ in combination with methotrexate: in vitro sensitivity studies in four human mesothelioma cell lines. Anti-Cancer Drugs 6: 77-82
8. Hunt KJ, Longlon G, Williams MA and Livingston RB (1996) Treatment of malignant mesothelioma with methotrexate and vinblastine, with or without platinum chemotherapy. Chest 109: 1239-1242
9. Ohnuma T, Szrajer L, Holland JF, Kurimoto M and Minowada J (1993) Effects of natural interferon alpha, natural tumor necrosis factor alpha and their combination on human mesothelioma xenografts in nude mice. Cancer Immunol Immunother 36: 31-36
10. Ong S and Vogelzang NJ (1996) Chemotherapy in malignant pleural mesothelioma: a review. J Clin Oncol 14: 1007-1017
11. Pass HW, Temeck BK, Kranda K, Steinberg SM and Pass III (1995) A phase II trial investigating primary immunochemotherapy for malignant pleural mesothelioma and the feasibility of adjuvant immunochemotherapy after maximal cytoreduction. Ann Surg Oncol 2: 214-220
12. Rusch V (1995) A proposed new international TNM staging system for malignant pleural mesothelioma. Chest 108: 1122-1128
13. Ryan CW, Herndon J and Vogelzang NJ (1998) A review of chemotherapy trials for malignant mesothelioma. Chest 113: 60S-73S
14. Shin DM, Fossella FV, Umsawasdi T, Murphy WK, Chasen MH, Walsh G, Komaki R, McMurtrey MJ and Hong WK (1995) Prospective study of combination chemotherapy with cyclophosphamide, doxorubicin, and cisplatin for unresectable or metastatic malignant pleural mesothelioma. Cancer 76: 2230-2236
15. Sklarin NT, Chaninian AP, Feuer EJ, Lahman LA, Szrajer L and Holland JF (1988) Augmentation of activity of cis-diamminedichloroplatinum(II) and mitomycin C by interferon in human malignant mesothelioma xenografts in nude mice. Cancer Res 48: 64-67
16. Solheim OP, Säter G, Finnanger AM and Stenwig AE (1992) High-dose methotrexate in the treatment of malignant mesothelioma of the pleura. A phase II study. Br J Cancer 65: 956-960
17. Soulie P, Ruffie P, Trandafir L, Monnet I, Tardivon A, Terrier P, Cvitkovic E, Le Chevalier T and Armand JP (1996) Combined system Chemoimmunotherapy in advanced diffuse malignant mesothelioma: report of phase I II study of weekly cisplatin/interferon α-2a. J Clin Oncol 14: 878-885
18. Stewart DJ, Gertler SZ, Tomiak A, Shamji F, Goel R, Evans WK (1994) High dose doxorubicin plus cisplatinin the treatment of unresectable mesotheliomas: report of four cases. Lung Cancer 11: 251-258
19. Tansan S, Emri S, Seleuk T, Koc Y, Hesketh P, Heeren T, McCaffrey RP and Baris YI (1994) Treatment of malignant pleural mesothelioma with cisplatin, mitomycin C and alpha interferon. Oncology 51: 348-3451
20. UICC (1992) International Union against Cancer: TNM Classification of Malignant Tumours. Springer Verlag: Berlin.
21. Upham JW, Musk AW, van Hazel G, Byrne M and Robinson BW (1993) Interferon alpha and doxorubicin in malignant mesothelioma: a phase II study. Aust NZ J Med 23: 683-687
22. Von Hoff DD, Metch B, Lucas JG, Balcerzak SP, Grunberg SM and Rivkin SE (1990) Phase II evaluation of recombinant interferon-beta (IFN-β ser) in patients with diffuse mesothelioma: a Southwest Oncology Group study. I Interferon Res 10: 531-534
23. Zeng L, Buard A, Monnet I, Boutin C, Fleury J, Saint-Etienne L, Brochard P, Bignon J and Jaurand MC (1993) In vitro effects of recombinant interferon gamma on human mesothelioma cell lines. Int J Cancer 55: 515-520