The effect of arginine or glycine supplementation on gastrointestinal function, muscle injury, serum amino acid concentrations and performance during a marathon run

International Journal of Sports Medicine

Volumn 20, Issue 5, 1999, Pages 315-321

  Buchman, A L ^a,e   O'Brien, W ^b   Ou, C N ^b   Rognerud, C ^b   Alvarez, M ^a   Dennis, K ^d   Ahn, C ^c  

^a UNIVERSITY OF TEXAS MEDICAL SCHOOL   (United States)

^b BAYLOR COLLEGE OF MEDICINE   (United States)

^c UNIVERSITY OF TEXAS   (United States)

^d Private Practice   (United States)

^e NONE   (United States)

Author keywords

Amino acids; Arginine; Intestinal ischemia; Marathon

Indexed keywords

AMINO ACID; AMYLASE; ARGININE; CREATINE KINASE; GLYCINE; LACTULOSE; MANNITOL; TRIACYLGLYCEROL LIPASE;

ABDOMINAL PAIN; ADULT; AMINO ACID BLOOD LEVEL; AMYLASE BLOOD LEVEL; ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CREATINE KINASE BLOOD LEVEL; DIARRHEA; DIET SUPPLEMENTATION; DOUBLE BLIND PROCEDURE; FECES; FEMALE; FLUID INTAKE; GASTROINTESTINAL HEMORRHAGE; GASTROINTESTINAL SYMPTOM; HUMAN; HUMAN EXPERIMENT; INDIGESTION; MALE; MARATHON RUNNER; MEMBRANE PERMEABILITY; MUSCLE INJURY; NAUSEA; NORMAL HUMAN; PAIN; PANCREAS INJURY; PERFORMANCE; PERMEABILITY; RANDOMIZED CONTROLLED TRIAL; SELF REPORT; TRIACYLGLYCEROL LIPASE BLOOD LEVEL; VOMITING;

ADULT; AMINO ACIDS; ARGININE; DIETARY SUPPLEMENTS; FEMALE; GASTROINTESTINAL HEMORRHAGE; GLYCINE; HUMANS; INTESTINAL DISEASES; ISCHEMIA; MALE; MIDDLE AGED; MUSCLE, SKELETAL; PAIN; PHYSICAL ENDURANCE; RUNNING;

EID: 0032767391     PISSN: 01724622     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-2007-971137     Document Type: Article

References (52)

1. Anderson RA, Polansky MM, Bryden NA, Roginski EE, Patterson KY, Reamer DC, Effect of exercise (running) on serum glucose, insulin, glucagon, and chromium excretion. Diabetes 1992; 31: 212-6
2. Aoki TT, Muller WA, Brennan MF, Cahill GF. Effect of glucagon on amino acid and nitrogen metabolism in fasting man. Metabolism 1974; 23: 805-14
3. Baker J, Carlson D, Ly P, Olivet E, Rampal S. Readability and sensitivity of two guiac-based fecal occult blood tests (abstr.). Gastroenterology 1988; 94: A5
4. Bloomstrand E, Hassmen P, Ekblom B, Newsholme EA. Administration of branched-chain amino acids during sustained exercise-effects on performance and on plasma concentration of some amino acids. EurJ Appl Physiol 1991; 63: 83-8
5. Buchman AL, Killip D, Ou CN, Rognerud CL, Pownall H, Dennis K, Dunn JK. Short-term vitamine E supplementation in marathon runners: a placebo-controlled trial. Nutrition 1999; 15: 278-283
6. Cicalese L, Caraceni P, Nalesnik MA, Borle AB, Schraut WH. Oxygen free radical content and neutrophil infiltration are important determinants in mucosal injury after rat small bowel transplantation. Transplantation 1996; 62: 161-6
7. Clausen JM. Effect on physical training on cardiovascular adjustments to exercise in man. Physiol Rev 1977; 57: 779-81
8. Conlay LA, Wurtman RJ, Lopez-Coviella IG, Blusztajn NK, Vacanti CA, Logue M, During M, Caballero B, Maher TJ, Evoniuk G. Effects on running the Boston marathon on plasma concentrations of large neutral amino acids. J Neural Trans 1989; 76: 65-71
9. Corson RJ, Paterson IS, O'Dwyer ST. Lower limb ischaemia and reperfusion alters gut permeability. Eur J Vasc Surg 1992; 6: 158-63
10. Decombaz J. Reinhardt P, Anantharaman K, von Glutz C, Poortmans JR. Biochemical changes in a 100 km run: free amino acids, urea and creatinine. Eur J Appl Physiol 1979; 41: 61-72
11. Ertan A, Schneider FE. Acute pancreatitis in long-distance runners. Am J Gastroenterol 1995; 90: 70-1
12. Felig WJ. Influence of endogenous insulin secretion on splanctric glucose and amino acid metabolism in men. J Gin Invest 1971; 50: 1702-1711
13. Fischer LR, MacMahon LF Jr, Ryan MJ, Larson D, Brand M. Gastrointestinal bleeding in competitive runners. Dig Dis Sci 1986; 31: 1226-8
14. Granger DN, Rutili G, McCord J. Superoxide radicals in feline intestinal ischemia. Gastroenterology 1981; 81: 22-9
15. Halvorsen FA, Lyng J, Glomsaker T, Ritland S. Gastrointestinal disturbances in marathon runners. Br J Sport Med 1990; 24: 266-8
16. Hansen KM, Bjerre-Knudsen J, Brodthagen U, Jordal R, Paulev PE. Muscle cell leakage due to long distance training. Eur J Appl Physiol 1982; 48: 177-88
17. Hikada RS, Staron RS, Hagerrnan FC, Sherman WM, Costill DL. Muscle fiber necrosis associated with human marathon runners. J Neurol Sci 1983; 59: 185-203
18. Huq F, Thompson M, Ruell P. Changes in serum amino acid concentrations during prolonged endurance training. Jpn J Physiol 1993; 43: 797-807
19. Ignarro LJ, Harbison RG, Wood KS, Kadowitz PJ. Activation of purified soluble guanylate cyclase by endothelium-derived relaxing factor from intrapulmonary artery and vein: stimulation by acetylcholine, bradykinin and arachidonic acid. J Pharmacol Ther 1986; 237: 893-7
20. Iijima S, Shou J. Naama H, Calvano SE, Daly JM. Beneficial effect of enteral glycine in intestinal ischemia/reperfusion injury. J Gastrointest Surg 1997; 1: 61-8
21. Jaffe RM, Kasten B, Young DS, MacLowry JD. False-negative stool occult blood tests caused by ingestion of ascorbic acid (vitamin C). Ann Intern Med 1982; 83: 824-6
22. Keefe EB, Lowe DK, Goss JR, Wayne R. Gastrointestinal symptoms of marathon runners. West J Med 1984; 141: 481-4
23. Kenney WL, Ho CW. Age alters regional distribution of blood flow during moderate-intensity exercise. J Appl Physiol 1995; 79: 1112-9
24. Kubes P, Granger DN. Nitric oxide modulates microvascular permeability. Am J Physiol 1992; 262: H611-5
25. Kubes P. Nitric oxide modulates epithelial permeability in the feline small intestine. Am J Physiol 1992; 264: G1138-42
26. Kubes P. Ischemia-reperfusion in the feline small intestine: a role for nitric oxide. Am J Physiol 1993; 264: G143-9
27. Lehmann M, Huonker M, Heinz N, Gastman U, Treis N, Steinecker JM, Keul J, Kajewski R, Häussinger D. Serum amino acid concentrations in nine athletes before and after the 1993 Colmar ultra marathon. Int J Sports Med 1995; 16: 155-9
28. Lilenquist JE, Lewis SB, Cherrington AD, Sinclair-Smith BC, Lacy WW. Effects on pharmocologic hyperglucagonemia on plasma amino acid concentrations in normal and diabetic men. Metabolism 1981; 30: 1195-1199
29. Maron MB, Horvath SM, Wilkerson JE. Acute blood biochemical alterations in response to marathon running. Eur J Appl Physiol 1975; 34: 173-81
30. Martensson J, Jain A, Meister A. Glutathionine is required for intestinal function. Proc Natl Acad Sci 1990; 87: 1715-9
31. McCabe ME, Peura DA, Kadakia SC, Bocek Z, Johnson LF. Gastrointestinal blood loss associated with running in marathon. Dig Dis Sci 1986; 31: 1229-32
32. Moses F, Singh A, Smoak B, Hollander D, Deuster P. Alterations in intestinal permeability during prolonged high intensity running (abstr.). Gastroenterology 1991; 100: A472
33. Naveri H, Rehunen S, Kuoppasalmi K, Tulikoura I, Härköen M. Muscle metabolism during and after strenuous intermittent running. Scand J Lab Invest 1978; 38: 329-36
34. O'Connor AM, Johnston CF, Buchanan KD, Trinick TR, Riddoch CJ. Circulating gastrointestinal hormone changes in marathon running. Int J Sports Med 1995; 16: 283-7
35. Øktedalen O, Lunde OC, Opstad PK, Aabakken L, Kverneba K. Changes in the gastrointestinal mucosa after long distance running, Scand J Gastroenterol 1992; 27: 270-4
36. Ostrow JD, Mulvaney CA, Hansell JR, Rhodes RS. Sensitivity and reproducibility of chemical tests for fecal occult blood with an emphasis on false-positive reactions. Am J Dig Dis 1973; 18: 930-40
37. Parks DA, Bulkey CB, Granger DN, Hamilton SR, McCord JM. Iscmic injury in the cat small intestine: role of superoxide radicals. Gastroenterology 1982; 82: 9-15
38. Parry-Billings M, Bloomstrand E, McAndrew N, Newsholme EA. A communicational link between skeletal muscle, brain, and cells of the immune system. Int J Sports Med 1980: 11: 5122-8
39. Payne D, Kubes P, Nitric oxide donors reduce the rise in reperfusion-induccd intestinal mucosal permeability. Am J Physiol 1993; 265: G189-95
40. Qamar MI, Read AE. Effect of exercise on mesenteric blood flow in man. Gut 1987; 28: 583-7
41. Rapoport RM, Murad F. Agonist-induced endothelium-dependent relaxation in rat thoracic aorta may be mediated through cGMP. Circ Res 1983; 52: 352-7
42. Raul F, Galluser M, Schleiffer F, Gosse F, Hasselmann M, Seiter N. Beneficial effects of L-arginine on intestinal epithelial restitution after ischemic damage in rats. Digestion 1995; 56: 400-5
43. Refsum HE, Gjessing LR, Stromme SB. Changes in plasma amino acid distribution and urine amino acid excretion during prolonged heavy exercise. Scand J Clin Lab Invest 1979; 39: 407-13
44. Rehrer NJ, Janssen GME, Brouns F, Saris WHM. Fluid intake and gastrointestinal problems in runners competing in a 25 km race and a marathon. Int J Sports Med 1989; 10: S22-5
45. Riddoch C, Trinick TR. Gastrointestinal disturbances in marathon runners. Br J Sports Med 1988; 22: 71-4
46. Rowell LB. Human cardiovascular adjustments to exercise and thermal stress. Physiol Rev 1974; 54: 75-159
47. Schleiffer R, Raul F. Prophylactic administration of L-arginine improves the intestinal barrier function after mesenteric ischaemia. Gut 1996; 39: 194-8
48. Shamoon H, Jacob R, Sherwin RS. Epinephrine induced hypoaminoacidemia in normal and diabetic human subjects: effects of beta blockade. Diabetes 1980; 29: 875-81
49. Stroehlein JR, Fairbanks VP, McGill DB, Go VWL. Reliability of fecal Hemocult test in various gastrointestinal disorders (abstr.). Gastroenterology 1975; 68: A93
50. Sullivan SN. The gastrointestinal symptoms of running (letter). N Engl Med 1981; 304: 915
51. Wade OL, Combes B, Childs AW, Wheelers HO, Cournand A, Bradley SE. The effect of exercise on the splanchnic blood flow and splanchnic blood volume in normal man. Clin Sci 1956; 15: 457-63
52. Yamada T, Taguchi T, Suita S. Energy metabolism and tissue flow as parameters for the assessment of graft viability in rat small bowel. J Pediatr Surg 1996: 31: 1475-81