Costs, benefits and limitations of genetic testing for cancer risk

British Journal of Cancer

Volumn 80, Issue SUPPL. 1, 1999, Pages 46-50

  Ponder, B A J ^a  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

BRCA1 PROTEIN; BRCA2 PROTEIN; ONCOPROTEIN;

BREAST CANCER; CANCER RISK; CANCER SCREENING; CLINICAL ARTICLE; CONFERENCE PAPER; COST BENEFIT ANALYSIS; FAMILIAL CANCER; FEMALE; GENETIC COUNSELING; GENETIC PREDISPOSITION; GENETIC SCREENING; HUMAN; HUMAN CELL; MALE; MEDICAL PRACTICE; ONCOGENE; OVARY CANCER; PATIENT EDUCATION; PRIORITY JOURNAL; THYROIDECTOMY;

COST-BENEFIT ANALYSIS; GENETIC SCREENING; HUMANS; NEOPLASMS; PEDIGREE; PREDICTIVE VALUE OF TESTS; RISK FACTORS;

EID: 0032767248     PISSN: 00070920     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Conference Paper

References (37)

1. Association of British Insurers (1997) Genetic Code of Practice. ABI: London
2. Burke W, Daly M, Garber J, Botkin J, Kahn MJ, Lynch P, McTiernan A, Offit K, Perlman J, Petersen G, Thomson E and Varricchio C (1997a) Recommendations for follow-up care of individuals with an inherited predisposition to cancer. II. BRCA1 and BRCA2. J Am Med Assoc 277: 997-1003
3. Burke W, Petersen G, Lynch P, Botkin J, Daly M, Judy G, Kahn MJE, McTiernan A, Offit K, Thomson E and Varricchio C (1997b) Recommendations for follow-up care of individuals with an inherited predisposition to cancer. I. Hereditary non-polyposis colorectal cancer. J Am Med Assoc 277: 915-919
4. Collins FS (1996) BRCA1 lots of mutations, lots of dilemmas. N Engl J Med 334: 186-188
5. de Bock GH, Perk DC, Ooslerwijk JC, Hageman GC, Kievit J and Springer MP (1997) Women worried about their familial breast cancer risk a study on genetic advice in general practice. Family Practice 14: 40-43
6. Doll (1995) The genetics of Common Diseases: a Second Report to the NHS Central Research and Development Committee on the New Genetics, Department of Health: London
7. Dunlop MG and Campbell H (1997) Screening for people with a family history of colorectal cancer. Brit Med J 314: 1779-1780
8. Dunlop MG, Farrington SM, Carothers AD, Wyllie AH, Sharp L, Burn J, Liu B, Kinzler KW and Vogelstein B (1997) Cancer risk associated with germline DNA mismatch repair gene mutations, Hum Mol Genet 6: 105-110
9. Easton DF, Ford D and Bishop DT (1995) Breast and ovarian cancer incidence in BRCA1-mutation carriers, Breast Cancer Linkage Consortium, Am J Hum Genet 56: 265-271
10. Ford D, Easton DF, Stratton M, Narod S, Goldgar D, Devilee P, Bishop DT, Weber B, Lenoir G, Chang-Claude J, Sopol H, Teare MD, Stuewing J, Arason A, Schemeck S, Peto J, Rebbeck TR, Tonin P, Neuhausen S, Barkardottir R, Eyfjord J, Lynch H, Pondei BAJ, Gayther SA, Birch JM, Lindblom A, Stoppa-Lyonnet D, Bignon Y, Borg A, Hamann V, Haites N, Scott RJ, Maugard CM, Vasen H, Seitz S, Cannon Albright LA, Schofield A, Zelada-Hedman M and the Breast Cancer Linkage Consortium (1998) Genetic heterogeneity and penetrance analysis of the BRCA1 and BRCA2 genes in breast cancer families. Am J Hum Genet 62: 676-689
11. Fuchs CS, Giovannucci EL, Colditz GA, Hunter DJ, Speizer FE, and Willett WC (1994) A prospective study of family history and the risk of colorectal cancer. N Engl J Med 331: 1669-1674
12. Hallowell N, Green JM, Statham H, Murton F and Richards MPM (1997) Recall of numerical risk estimates and counsellees' perceptions of the importance of risk information following genetic counselling for breast and ovarian cancer Psychol Health Med 2: 149-159
13. Harris R (1994) Breast cancer among women in their forties: toward a reasonable research agenda. J Natl Cancer Inst 86: 410-412
14. Harris R and Harris JH (1995) Primary care for patients at genetic risk. Br Med J 311: 579-580
15. Healey B (1997) BRCA genes bookmaking, fortunetelling and medical care. N Engl J Med 336: 1448-1449
16. House of Commons Science and Technology Committee (1995) Human Genetics: the Science and the Consequences. HMSO: London
17. Hubbard R and Lewontin RC (1996) Sounding board: pitfalls of genetic testing. N Engl J Med 334: 1192-1194
18. Hudson KL, Rothenberg KH, Andrews LB, Kahn MJ and Collins FS (1995) Genetic discrimination and health insurance: an urgent need for reform. Science 270: 391-393
19. Jarvinen HJ, Mecklin JP and Sistonen P (1995) Screening reduces colorectal cancer rate in families with hereditary nonpolyposis colorectal cancer. Gastroenterology 108: 1405-1411
20. Kahn P (1996) Coming to grips with genes and risk. Science 274: 496-498
21. Kash KM, Holland JC, Osborne MP and Miller DG (1995) Psychological counselling strategics for women at risk for breast cancer. Monogr Natl Cancer Inst 17: 73-39
22. Krainer M, Silva-Arrieta S, FitzGerald MG, Shimada A, Ishioka C, Kanamaru R, MacDonald DJ, Unsal H, Finkelstein DM, Bowcock A, Isselbacher KJ and Haber DA (1997) Differential contributions of BRCA1 and BRCA2 to early-onset breast cancer. N Engl J Med 336: 1416-1421
23. Lerman C, Daly M, Masny A and Bashem A (1994) Attitudes about genetic testing for breast ovarian cancer susceptibility. J Clin Oncol 12: 843-850
24. Li FP, Garber JG, Friend SH, Strong LC, Patenaude AF, Juengst ET, Reilly PR, Correa P and Fraumeni JF (1992) Recommendations on predictive testing for germline mutations among cancer prone individuals, J Natl Cancer Inst 84: 1156-1160
25. Lips CJM, Landsvater RM, Hoppener JWM, Geerdink RA, Blijham G, van Veen JM, van Gils AP, de Wit MJ, Zewald RA, Berends MJ, Beemer PA, Brouwerssmalbraak J, Jansen RPM, Vanamstel HKP, Vanvroonhoven TJM and Vroom TM (1994) Clinical screening as compared with DNA analysis in families with multiple endocrine neoplasia type 2A. New Engl J Med 331: 828-835
26. Liu B, Farrington SM, Petersen GM, Hamilton SR, Parsons R, Papadopoulos N, Fujiwara T, Jen J, Kinzler KW, Wyllie AH, Vogelstein B and Dunlop MG (1995) Genetic instability occurs in the majority of young patients with colorectal cancer. Nat Med 1: 348-352
27. Liu B, Parsons R, Papadopoulos N, Nicolaides NC, Lynch HT, Watson P, Jass JR, Dunlop M, Wyllie A, Peltomaki P, de la Chapelle A, Hamilton SR, Vogelstein B and Kinzler KW (1996) Analysis of mismatch repair genes in hereditary non-polyposis colorectal cancer. Nat Med 2: 169-174
28. Marshall A (1996) Genetic tests forge ahead despite scientific concerns. Nat Biotechnol 14: 1642-1643
29. Mazoyer S, Dunning AM, Serova O, Dearden J, Puget N, Healey CS, Gayther SA, Mangion J, Stratton MR, Lynch HT, Goldgar DE, Ponder BA and Lenoir GM (1996) A polymorphic stop codon in BRCA2. Nat Genet 14: 253-254
30. Miki Y, Swensen J, Shattuck-Eidens D, Futreal PA, Harshman K, Tavtigian S, Liu QY, Cochran C, Bennett LM, Ding W, Bell R, Rosenthal J, Hussey C, Tran T, McClure M, Frye C , Hattier T, Phelps R, Haugenstrano A, Katcher H, Yakumo K, Gholami Z, Shaffer D, Stone S, Bayer S, Wray C, Bogden R, Dayananth P, Ward J, Tonin P, Nafod S, Brislow PK, Norris FH, Helvering L, Morrison P, Rosteck P, Lai M, Barrett JC, Lewis C, Neuhausen S, Cannon-Albright L, Goldgar D, Wiseman R, Kamb A and Skolnick MH (1994) A strong candidate for the breast and ovarian cancer susceptibility gene BRCA1. Science 266: 66-71
31. Nelson NJ (1996) Caution guides genetic lesting for hereditary cancer genes. J Natl Cancer Inst 88: 70-72
32. Rothenberg K, Fuller B, Rothstein M, Duster T, Ellis Kahn MJ, Cunningham R, Fine B, Hudson K, King MC, Murphy P, Swergold G and Collins K (1997) Genetic information and the workplace: legislative approaches and policy changes. Science 275: 1755-1757
33. Schrag D. Kuntz KM, Garber JE and Weeks JC (1997) Decision analysis effects of prophylactic mastectomy and oophorectomy on lite expectancy among women with BKCA1 or BKCA2 mutations. N Engl J Med 336: 1465-1471
34. Slattery ML and Kerber RA (1994) Family history of cancer and colon cancer risk, the Utah population database. J Natl Cancer Inst 86: 1618-1626
35. Streuwing J, Hartge P, Wacholder S, Baker SM, Berlin M, McAdams M, Timmerman MM, Brody L and Tucker M (1997) The risk ot cancer associated with specific mutations of BRCA1 and BRCA2 among Ashkenazi Jews. N Engl J Med 336: 1401 -1408
36. Vasen HF, Mecklin JR Meera Khan P and Lynch HT (1991) The International Collaborative Group on Hereditary Nonpolypo.si.s Coloreclal Tancer (ICG-HNPCC). Dis Colon Rectum 34: 424-425
37. Wooster K, Bignell G, Lancaster J, Swift S, Seal S, Mangion J, Collins N, Gregory S, Gumbs, Micklem G, Barfoot K. Hamoudi R, Patel S, Rice C, Biggs P, Hashim Y, Smith A, Connor F, Arason A, Gudmundsson J, Ficenec D, Kelsell D, Ford D, Tonin P, Bishop DT. Spurr NK, Ponder BAJ, Eeles R, Peto J, Devilee P, Cornelisse C, Lynch H, Narod S, Lenoir G, Egilsson V, Bjork Barkadottir R, Easton DF, Bentlry DR, Futreal PA, Ashworth A and Stratton MR (1995) Identification of the breast cancer susceptibility gene BRCA2. Nature 378: 789-792