Is hypertonic saline an effective alternative to mannitol in the treatment of elevated intracranial pressure in pediatric patients?

Journal of Intensive Care Medicine

Volumn 14, Issue 4, 1999, Pages 184-188

  Vats, Atul ^a   Chambliss, C Robert ^b   Anand, K J S ^c   Pettignano, Robert ^b  

^a UNIVERSITY OF TEXAS MEDICAL BRANCH   (United States)

^b EMORY UNIVERSITY   (United States)

^c ARKANSAS CHILDREN S HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MANNITOL; SODIUM CHLORIDE;

ADOLESCENT; BRAIN PERFUSION; CHILD; CLINICAL ARTICLE; DRUG EFFICACY; HEART RATE; HEMODYNAMICS; HUMAN; INFANT; INTRACRANIAL HYPERTENSION; INTRACRANIAL PRESSURE; MEAN ARTERIAL PRESSURE; PEDIATRICS; PRIORITY JOURNAL; REVIEW; TREATMENT OUTCOME;

EID: 0032766721     PISSN: 08850666     EISSN: None     Source Type: Journal    
DOI: 10.1177/088506669901400403     Document Type: Review

References (18)

1. Taylor G, Myers S, Kurth CD, et al. Hypertonic saline improves brain resuscitation in a pediatric model of head injury and hemorrhagic shock. J Pediatr Surg 1996;31:65-71
2. Zornow MH, Todd MM, Moore SS. The acute cerebral effects of changes in plasma osmolality and oncotic pressure. Anesthesiology 1987;67:936-941
3. Velasco IT, Pontieri V, Rocha e Silva MJr, et al. Hyperosmotic NaCl and severe hemorrhagic shock. Am J Physiol 1980; 239:H664-H673
4. Prough DS, Johnson JC, Poole GV Jr, et al. Effects on intracranial pressure of resuscitation from hemorrhagic shock with hypertonic saline versus lactated Ringer's solution. Crit Care Med 1985;13:407-411
5. Worthley LI, Cooper DJ, Jones N. Treatment of resistant intracranial hypertension with hypertonic saline. J Neurosurg 1988;68:478-481
6. Battistella FD, Wisner DH. Combined hemorrhagic shock and head injury: effects of hypertonic saline (7.5%) resuscitation. J Trauma 1991;31:182-188
7. Berger S, Schurer L, Hartl R, et al. 7.2% NaCl/10% dextran 60 versus 20% mannitol for treatment of intracranial hypertension. Acta Neurochir Suppl 1994;60:494-498
8. Freshman SP, Battistela FD, Matteucci M, et al. Hypertonic saline (7.5%) versus mannitol: a comparison for treatment of acute head injuries. J Trauma 1993;35:344-348
9. Prough DS, Whitley JM, Taylor CL, et al. Regional cerebral blood flow following resuscitation from hemorrhagic shock with hypertonic saline: influence of a subdural mass. Anesthesiology 1991;75:319-327
10. Shackford SR, Zhuang J, Schmoker J. Intravenous fluid tonicity: effect on intracranial pressure, cerebral blood flow, and cerebral oxygen delivery in focal brain injury. J Neurosurg 1992;76:91-98
11. Wisner DH, Schuster L, Quinn C. Hypertonic saline resuscitation of head injury: effects on cerebral water content. J Trauma 1990;30:75-78
12. Anderson JT, Wisner DH, Sullivan PE, et al. Initial small-volume hypertonic resuscitation of shock and brain injury: short- and long-term effects. J Trauma 1997;42:592-601
13. Berger S, Schürer L, Härtl R, et al. Reduction of post-traumatic intracranial hypertension by hypertonic/hyperoncotic saline/dextran and hypertonic mannitol. Neurosurgery 1995; 37:98-108
14. Fisher B, Thomas D, Peterson B. Hypertonic saline lowers raised intracranial pressure in children after head trauma. J Neurosurg Anesthesiol 1992;4:4-10
15. Marshall LW, Smith RW, Shapiro HM. The outcome with aggressive treatment in severe head injuries. 1. The significance of intracranial pressure monitoring. J Neurosurg 1979; 50:20-25
16. Saul TG, Ducker TV. Effect of intracranial pressure monitoring and aggressive treatment on mortality in severe head injury. J Neurosurg 1982;56:498-503
17. Shackford SR. Effect of small-volume resuscitation on intracranial pressure and related cerebral variables. J Trauma 1997;42:S48-S53
18. Chestnut RM. Secondary brain insults after head injury: clinical perspectives. New Horiz 1995;3:366-375