Palliative chemotherapy and radiotherapy for pancreatic cancer: Is it worthwhile?

World Journal of Surgery

Volumn 23, Issue 9, 1999, Pages 950-953

  Van Der Schelling, George P ^a   Jeekel, Johannes ^a  

^a ERASMUS MEDICAL CENTER   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

CISPLATIN; CYCLOPHOSPHAMIDE; CYPROTERONE ACETATE; FLUOROURACIL; GAMMA INTERFERON; GEMCITABINE; GESTAGEN; INTERLEUKIN 2; MELPHALAN; METHOTREXATE; MITOMYCIN C; MONOCLONAL ANTIBODY; SOMATOSTATIN DERIVATIVE; TAMOXIFEN; VINCRISTINE;

ADVANCED CANCER; CANCER CHEMOTHERAPY; CANCER PAIN; CANCER PALLIATIVE THERAPY; CANCER RADIOTHERAPY; CANCER RECURRENCE; CANCER SURVIVAL; CLINICAL TRIAL; CONFERENCE PAPER; DIARRHEA; DISSEMINATED CANCER; FEVER; HUMAN; INTRAARTERIAL DRUG ADMINISTRATION; LEUKOPENIA; NAUSEA; PANCREAS CANCER; REGIONAL PERFUSION; SECOND LOOK SURGERY;

ANTIMETABOLITES, ANTINEOPLASTIC; DEOXYCYTIDINE; HUMANS; PALLIATIVE CARE; PANCREATIC NEOPLASMS; SURVIVAL ANALYSIS;

EID: 0032765933     PISSN: 03642313     EISSN: None     Source Type: Journal    
DOI: 10.1007/s002689900605     Document Type: Conference Paper

References (19)

1. Mallinson, C.N., Rake, M.O., Cocking, J.B.: Chemotherapy in pancreatic cancer: results of a controlled, prospective, randomised, multicentre trial. B.M.J. 281:1589, 1980
2. Cullinan, S., Moertel, C.G., Wienand, H.S., Schutt, A.J., Krook, J.E., Foley, J.F., Norris, B.D., Kardinal, C.G., Tschetter, L.K., Barlow, J.F.: A phase III trial on the therapy of advanced pancreatic carcinoma: evaluations of the Mallinson regimen and combined 5-fluorouracil, doxorubicin, and cisplatin. Cancer 65:2207, 1990
3. Rothman, H., Cantrell, J.E., Jr., Lokich, J., Difino, S., Harvey, J., Ahlgren, J., Fryer, J.: Continuous infusion 5-fluorouracil plus weekly cisplatin for pancreatic carcinoma: a Mid-Atlantic Oncology Program study. Cancer 68:264, 1991
4. Bakkevold, K.E., Pettersen, A., Arnesjo, B., Espehaug, B.: Tamoxifen therapy in unresectable adenocarcinoma of the pancreas and the papilla of Vater. Br. J. Surg. 77:725, 1990
5. Klijn, J.G.M., Hoff, A.M., Planting, A.S.T., Verweij, J., Kok, T., Lamberts, S.W., Portengen, H., Foekens, J.A.: Treatment of patients with metastatic pancreatic and gastrointestinal tumours with the somatostatin analogue Sandostatin: a phase II study including endocrine effects. Br. J. Cancer 62:627, 1990
6. Keating, J.J., Johnson, P.J., Cochrane, A.M.G., Grazzard, B.G., Krasner, N., Smith, P.M.: A prospective randomised controlled trial of tamoxifen and cyproterone acetate in pancreatic carcinoma. Br. J. Cancer 60:789, 1989
7. Andrem-Sandberg, A.: Treatment with LHRH analogue in patients with advanced pancreatic cancer. Acta Chir. Scand. 156:549, 1990
8. Tempero, M.A., Sivinski, C., Steplewski, Z., Harvey, E., Klassen, L., Kay, H.D.: Phase II trial of interferon gamma and monoclonal antibody 17-1A in pancreatic cancer: biological and clinical effects. J. Clin. Oncol. 8:2019, 1990
9. Weiner, L.M., Harvey, E., Padavic-Shaller, K., Willson, J.K., Walsh, C., Lacreta, F., Khazaeli, M.B., Kirkwood, J.M., Haller, D.G.: Phase II multicenter evaluation of prolonged murine monoclonal antibody 17-1A therapy in pancreatic carcinoma. J. Immunother. 13:110, 1993
10. Rothenberg, M.L., Moore, M.J., Cripps, M.C., Andersen, J.S., Portenoy, R.K., Burris, H.A., III, Green, M.R., Tarassoff, P.G., Brown, T.D., Casper, E.S., Storniolo, A.M., Von Hoff, D.D.: A phase II trial of gemcitabine in patients with 5-FU-refractory pancreas cancer. Ann. Oncol. 7:347, 1996
11. Burris, H.A., III, Moore, M.J., Andersen, J., Green, M.R., Rothenberg, M.L., Modiano, M.R., Cripps, M.C., Portenoy, R.K., Storniolo, A.M., Tarassoff, P., Nelson, R., Door, F.A., Stephens, C.D., Von Hoff, D.D.: Improvements in survival and clinical benefit with gemcitabine as first-line therapy for patients with advanced pancreatic cancer: a randomized trial. J. Clin. Oncol. 15:2403, 1997
12. Moertel, C.G., Frytak, S., Hahn, R.G., O'Conell, M.J., Reitemeier, R.J., Rubin, J., Schutt, A.J., Vetland, L.H., Childs, D.S., Holbrook, M.A., Levin, P.I., Livestone, B., Spiro, H., Knovton, A., Kaiser, M., Barkin, J., Lessner, H., Mann-Kaplan, R., Ramming, K., Douglas, H.O., Jr., Thomas, P., Nave, H., Bateman, J., Lokich, J., Brooks, J., Chaffey, J., Corson, J.M., Zascheck, N., Novak, J.V.: Gastrointestinal Tumor Study Group: Therapy of locally unresectable pancreatic carcinoma: a randomized comparison of high dose (6000 rads) radiation alone, moderate dose radiation (4000 rads + 5-fluorouracil), and high dose radiation (6000 rads) + 5-fluorouracil. Cancer 48:1705, 1981
13. Jeekel, J., Treurniet-Donker, A.D.: Treatment perspectives in locally advanced unresectable pancreatic cancer. Br. J. Surg. 78:1332, 1991
14. Pilepich, M.V., Miller, H.H.: Preoperative irradiation in carcinoma of the pancreas. Cancer 46:1945, 1980
15. Hoffman, J.P., Weese, J.L., Lawrence, J.S., Engstrom, P., Agarwal, P., Barber, L.W., Guttmann, M.C., Litwin, S., Salazar, H., Eisenberg, B.L.: A pilot study of preoperative chemoradiation for patients with localized adenocarcinoma of the pancreas. Am. J. Surg. 169:71, 1995
16. Jessup, J.M., Steele, G., Jr., Mayer, R.J., Posner, M., Busse, P., Cady, B., Stone, M., Jenkins, R., Osteen, R.: Neoadjuvant therapy for unresectable pancreatic adenocarcinoma, Arch. Surg. 128:559, 1993
17. Ballard, R.B., Hoffman, J.P., Guttman, M.C., Barber, L., Litwin, S.: How accurate is size measurement of pancreas cancer masses by computed axial tomography (CT) scanning? Am. Surg. 61:686, 1995
18. Menke-Pluymers, M.B.E., Klinkenbijl, J.H.G., Tjioe, M., Jeekel, J.: Treatment of locoregional recurrence after intentional curative resection of pancreatic cancer. Hepatogastroenterology 39:429, 1992
19. Aigner, K.R., Gailhofer, S.: Celiac axis infusion (MMC, CDDP, 5-FU) and aortic stop-flow infusion vs. abdominal hypoxic perfusion (MMC) in UICC stage II/IV pancreatic cancer: 48 patients. Reg. Cancer Treat. 6(Suppl. 1):3, 1993