Apocynins A - D: New phenylpropanoid-substituted flavan-3-ols isolated from leaves of Apocynum venetum (Luobuma-Ye)

Chemical and Pharmaceutical Bulletin

Volumn 47, Issue 7, 1999, Pages 1049-1050

  Fan, Wenzhe ^a   Tezuka, Yasuhiro ^a   Xiong, Quanbo ^a   Hattori, Masao ^a   Namba, Tsuneo ^a   Kadota, Shigetoshi ^a  

^a UNIVERSITY OF TOYAMA   (Japan)

Author keywords

Apocynaceae; Apocynin; Apocynum venetum; Hepatoprotective activity; Luobuma Ye; Phenylpropanoid substituted flavan 3 ol

Indexed keywords

APOCYNIN; CATECHIN; CATECHIN [8,7 E] 4ALPHA (3,4 DIHYDROXYPHENYL) DIHYDRO 3(3H) PYRANONE; EPICATECHIN; EPIGALLOCATECHIN; FLAVANOL DERIVATIVE; GALACTOSAMINE; GALLOCATECHIN; PLANT EXTRACT; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL DEATH; DRUG ISOLATION; LIVER CELL CULTURE; LIVER PROTECTION; NONHUMAN; PROTON NUCLEAR MAGNETIC RESONANCE; SPECTROSCOPY;

EID: 0032765177     PISSN: 00092363     EISSN: None     Source Type: Journal    
DOI: 10.1248/cpb.47.1049     Document Type: Article

References (15)

1. Pharmacopoeia Committee of the Health Ministry of the People's Republic of China (ed.), Pharmacopoeia of People's Republic of China, Vol. 1, Guangdong Scientific Technologic Publisher, Guangdong, 1995, pp. 182-183.
2. Wei J. M., J. Trad. Chin. Med., 8, 34-36 (1988).
3. Yokozawa T., Dong E., Kashiwagi H., Kim D. W., Hattori M., Kadota S., Namba T., Natural Medicine, 51, 325-330 (1997); Kim D. W., Yokozawa T., Hattori M., Kadota S., Namba T., Phytother. Res., 12, 46-48 (1998);
4. Yokozawa T., Dong E., Kashiwagi H., Kim D. W., Hattori M., Kadota S., Namba T., Natural Medicine, 51, 325-330 (1997); Kim D. W., Yokozawa T., Hattori M., Kadota S., Namba T., Phytother. Res., 12, 46-48 (1998);
5. idem, J. Trad. Med., 13, 306-307 (1996);
6. idem, ibid., 15, 40-44 (1998).
7. Leist M., Gantner F., Bohlinger I., Germann P. G., Tiegs G., Wendel A. J., Immunology., 153, 1778-1788 (1994).
8. Foo L. Y., Phytochemistry, 26, 2825-2830 (1987). After this report, the structures of cinchonains Ia-Id were revised (Reference 6), and thus the structure formulas 2 and 3 (also 4 and 5) in the paper should be interchanged.
9. Chen H. F., Tanaka T., Nonaka G., Fujioka T., Mihashi K., Phytochemistry, 33, 183-187 (1993).
10. Nonaka G., Nishioka I., Chem. Pharm. Bull., 30, 4268-4276 (1982).
11. -5, MeOH, nm): -13200 (233). Inhibition rates (%) at 20, 40, and 80 μM: 15.6, 24.4, 60.0.
12. -5, MeOH, nm): +7590 (233). Inhibition rates (%) at 20, 40, and 80 μM: 2.7, 13.0, 39.6.
13. -5, MeOH, nm): -9900 (233). Inhibition rates (%) at 20, 40, and 80 μM: 9.5, 14.2, 46.1.
14. -5, MeOH, nm): +6930 (233). Inhibition rates (%) at 20, 40, and 80UμM: 12.3, 13.4, 36.8.
15. Inhibition rates (%) of 5, 6, and silibinin, a positive control, at 20, 40, and 80μM: 5, 10.7, 13.6, 44.5; 6, 26.6, 47.3, 95.1; silibinin, 14.8, 39.4, 86.4.