Sporostatin, a novel and specific inhibitor of EGF receptor kinase

Anticancer Research

Volumn 19, Issue 5 B, 1999, Pages 4145-4149

  Murakami, Yuko ^a   Ishii, Ayako ^a   Mizuno, Satoshi ^a   Yaginuma, Satoshi ^b   Uehara, Yoshimasa ^a  

^a NATIONAL INSTITUTE OF INFECTIOUS DISEASES   (Japan)

^b ASAHI CHEMICAL INDUSTRY CO   (Japan)

Author keywords

EGF receptor; Inhibitor; Tyrosine kinase

Indexed keywords

ADENOSINE TRIPHOSPHATE; EPIDERMAL GROWTH FACTOR RECEPTOR; GRISEOFULVIN; PROTEIN TYROSINE KINASE;

ARTICLE; AUTOPHOSPHORYLATION; CONTROLLED STUDY; ENZYME INHIBITION; HUMAN; HUMAN CELL; KINETICS; PRIORITY JOURNAL;

EID: 0032764047     PISSN: 02507005     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (12)

1. Yamamoto T, Kamata N, Kawano H, Shimizu S, Kuroki T, Toyoshima K, Rikimaru K, Nomura N, Ishizaki R, Pastan I, Gamou S and Shimizu N: High incidence of amplification of the epidermal growth factor receptor gene in human squamous carcinoma cell lines. Cancer Res 46: 414-416, 1986.
2. Slamon DJ, Godolphin W, Jones LA, Holt JA, Wong SG, Keith DE, Levin WJ, Stuart SG, Udove J and Ullrich A: Studies of the HER-2/neu proto-oncogene in human breast and ovarian cancer. Science 244: 707-712, 1989.
3. Turner A, Zseho K, Martin F, Jacobsen F, Bennett L and Broudy V: Nonhematopoietic tumor cell lines express stem cell factor and display c-kit receptors. Blood 80: 374-81, 1992.
4. Smanik PA, Furminger TL, Mazzaferri EL, Jhiang SM: Breakpoint characterization of the ret/PTC oncogene in human papillary thyroid carcinoma. Hum Mol Genet 4: 2313-2318, 1995.
5. Kinoshita K, Sasaki T, Awata M, Takada M and Yaginuma S: Structure of sporostatin (M5032), an inhibitor of cyclic adenosine 3′,5′-monophosphate phosphodiesterase. Jpn J Antibiot 50: 961-964, 1997.
6. Hanai N, Nores G, Torres-Mendez C and Hakomori S: Modified ganglioside as a possible modulator of transmembrane signaling mechanism through growth factor receptors: a preliminary note. Biochemical Biophysical Research Communication 147: 127-134, 1987.
7. Bertics PJ and Gill GN: Self-phosphorylation enhances the protein-tyrosine kinase activity of the epidermal growth factor receptor. J Biol Chem 260: 14642-7, 1985.
8. Murakami Y, Fukazawa H, Mizuno S and Uehara Y: Conversion of epidermal growth factor (EGF) into a stimulatory ligand for A431-cell growth by herbimycin A by decreasing the level of expression of EGF receptor. Biochem J 301: 57-62, 1994.
9. Fukazawa H, Li P-M, Mizuno S and Uehara Y: Method for simultaneous detection of protein kinase A, protein kinase C, protein tyrosine kinase, and calmodulin-dependent protein kinase activities. Analytycal Biochemistry 212: 106-110, 1993.
10. Li P, Fukazawa H, Yamamoto C, Mizuno S, Tanaka K, Hori M, Yaginuma S, Saito T and Uehara Y: Method of identifying inhibitors of oncogenic transformation: selective inhibition of cell growth in serum-free medium. Oncogene 8: 1731-1735, 1993.
11. Zhan X and Goldfarb M: Growth factor requirements of oncogene-transformed NIH 3T3 and BALB/c 3T3 cells cultured in defined media. Mol Cell Biol 6: 3541-3544, 1986.
12. Levitzki A: Tyrphostin: tyrosine kinase blockers as novel antiproliferative agents and dissectors of signal transduction. The FASEB Journal 6: 3275-3282, 1992.