Association between M/L55-polymorphism of paraoxonase enzyme and oxidative DNA damage in patients with type 2 diabetes mellitus and in control subjects

Human Genetics

Volumn 105, Issue 1-2, 1999, Pages 179-180

  Malin, Riikka ^a,b   Rantalaiho, Vappu ^a   Huang, Xiao Hong ^a,b   Wirta, Ole ^a   Pasternack, Amos ^a   Leinonen, Janne S ^a   Alho, Hannu ^c   Jokela, Hannu ^a   Koivula, Timo ^a   Tanaka, Tomoyuki ^d   Okada, Kunihiko ^d   Ochi, Hiromoto ^e   Toyokuni, Shinya ^d   Lehtimäki, Terho ^a,b  

^a TAMPERE UNIVERSITY HOSPITAL   (Finland)

^b TAMPERE UNIVERSITY OF TECHNOLOGY   (Finland)

^c UNIVERSITY OF HELSINKI   (Finland)

^d KYOTO UNIVERSITY   (Japan)

^e Japan Inst for the Control of Aging   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

8 HYDROXYDEOXYGUANOSINE; ARYLDIALKYLPHOSPHATASE; LEUCINE; LOW DENSITY LIPOPROTEIN; METHIONINE;

ARTICLE; ATHEROSCLEROSIS; CONTROLLED STUDY; DNA DAMAGE; DNA POLYMORPHISM; FINLAND; GENOTYPE; GLOMERULUS FILTRATION RATE; HUMAN; LIPID PEROXIDATION; MAJOR CLINICAL STUDY; NON INSULIN DEPENDENT DIABETES MELLITUS; PRIORITY JOURNAL; URINARY EXCRETION;

ARYLDIALKYLPHOSPHATASE; CASE-CONTROL STUDIES; DEOXYGUANOSINE; DIABETES MELLITUS, TYPE 2; DNA DAMAGE; ESTERASES; FEMALE; GENOTYPE; HUMANS; LIPID PEROXIDATION; MALE; POLYMORPHISM, GENETIC;

GLOMERULUS;

EID: 0032763487     PISSN: 03406717     EISSN: None     Source Type: Journal    
DOI: 10.1007/s004399900074     Document Type: Article

References (6)

1. Garin M-CB, James RW, Dussoix P, Blanché H, Passa P, Froguel P, Ruiz J (1997) Paraoxonase polymorphism Met-Leu54 is associated with modified serum concentrations of the enzyme. A possible link between the paraoxonase gene and increased risk of cardiovascular disease in diabetes. J Clin Invest 99:62-66
2. Humbert R, Adler DA, Disteche C, Hassett C, Omiecinski CJ, Furlong CE (1993) The molecular basis of the human serum paraoxonase activity polymorphism. Nat Genet 3:73-76
3. Mackness B, Mackness MI, Arrol S, Turkie W, Durrington PN (1998) Effect of the human serum paraoxonase 55 and 192 genetic polymorphisms on the protection by high density lipoprotein against low density lipoprotein oxidative modification. FEBS Lett 423:57-60
4. Ruiz J, Blanché H, James RW, Garin M-CB, Vaisse C, Charpentier G, Cohen N, Morabia A, Passa P, Froguel P (1995) Gln-Arg 192 polymorphism of paraoxonase and coronary heart disease in type 2 diabetes. Lancet 346:869-872
5. Shigenaga MK, Gimeno CJ, Ames BN (1989) Urinary 8-hydroxy-2'-deoxyguanosine as a biological marker of in vivo oxidative DNA damage. Proc Natl Acad Sci USA 86:9697-9701
6. Toyokuni S, Tanaka T, Hattori Y, Nishiyama Y, Yoshida A, Uchida K, Hiai H, Ochi H, Osawa T (1997) Quantitative immunohistochemial determination of 8-hydroxy-2'-deoxyguanosine by a monoclonal antibody N45.1: its application to ferric nitrilotriacetate-induced renal carcinogenesis model. Lab Invest 76:365-374