Drug sensitivities of the primary afferents and their changes after inflammation

Clinical Orthopaedics and Related Research

Volumn 369, Issue , 1999, Pages 340-348

  Abe, Masahiro ^a   Yoshioka, Koichi ^a   Shinomiya, Kenichi ^a   Nakai, Osamu ^b  

^a TOKYO MEDICAL AND DENTAL UNIVERSITY   (Japan)

^b Kudanzaka Hospital   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

4 AMINOBUTYRIC ACID; ACETYLCHOLINE; BRADYKININ; CAPSAICIN; HISTAMINE; SEROTONIN;

ADOLESCENT; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DORSAL ROOT POTENTIAL; FEMALE; GANGLION; MULTIPLE CHEMICAL SENSITIVITY; MUSCLE SPINDLE AFFERENT NERVE; NEWBORN; NONHUMAN; PRIMARY AFFERENT DEPOLARIZATION; PRIORITY JOURNAL; RADICULAR PAIN; RADICULITIS; RAT; SPINAL REFLEX; VENTRAL ROOT;

EID: 0032763262     PISSN: 0009921X     EISSN: 15281132     Source Type: Journal    
DOI: 10.1097/00003086-199912000-00036     Document Type: Article

References (32)

1. Akagi H, Konishi S, Otsuka M, Yanagisawa M: The role of substance P as a neurotransmitter in the reflexes of slow time course in the neonatal rat spinal cord. Br J Pharmacol 84:663-673, 1985.
2. Atsuta Y, Iwahara T, Sugawara O, et al: The study of generating and suppressive factors of ectopic firing on the lumbar dorsal root using an in vitro model. Rinsho Seikei Geka 29:441-448, 1994. In Japanese.
3. Atsuta Y, Iwahara T, Takemitsu Y: Biochemical effects of the nucleus pulposus component. Spine 19:2369-2370, 1994. Letter, comment.
4. Bhisitkul RB, Villa JE, Kocsis JD: Axonal GABA-receptors are selectively present on normal and regenerated sensory fibers in rat peripheral nerve. Exp Brain Res 66:659-663, 1987.
5. Brown DA, Marsh S: Axonal GABA-receptors in mammalian peripheral nerve trunks. Brain Res 156: 187-191, 1978.
6. B receptors on Aδ and C primary afferents. Br J Pharmacol 81:327-333, 1984.
7. Dray A, Bettaney J, Forster P, Perkins MN: Activation of a bradykinin receptor in peripheral nerve and spinal cord in the neonatal rat in vitro. Br J Pharmacol 95:1008-1010, 1988.
8. Dunn PM, Rang HP: Bradykinin-induced depolarization of primary afferent nerve terminals in the neonatal rat spinal cord in vitro. Br J Pharmacol 100:656-660, 1990.
9. El Mahdi MA, Abdel Latif FY, Janko M: The spinal nerve root 'innervation,' and a new concept of the clinicopathological interrelations in back pain and sciatica. Neurochirurgia 24:137-141, 1981.
10. Higashi H, Ueda N, Nishi S, et al: Chemoreceptors for serotonin (5-HT), acetylcholine (Ach), bradykinin (BK), histamine (H) and γ-aminobutyric acid (GABA) on rabbit visceral afferent neurons. Brain Res Bull 8:23-32, 1982.
11. Holmes JM, Sworn BR: Lumbo-sacral root pain. Br Med J 22:946-948, 1946.
12. Howe JF, Loeser JD, Calvin WH: Mechanosensitivity of dorsal root ganglia and chronically injured axons: A physiological basis for the radicular pain of nerve root compression. Pain 3:25-41, 1977.
13. Kawakami M, Weinstein JN, Chatani K, et al: Experimental lumbar radiculopathy. Spine 19:1795-1802, 1994.
14. Kingery WS, Fields RD, Kocsis JD: Diminished dorsal root GABA sensitivity following chronic peripheral nerve injury. Exp Neurol 100:478-490, 1988.
15. Lehmann HJ, Ule G: Electrophysiological findings and structural changes in circumscript inflammation of peripheral nerves. Progr Brain Res 6:169-173, 1964.
16. Lindahl O: Hyperalgesia of the lumbar nerve roots in sciatica. Acta Orthop Scand 37:367-374, 1966.
17. Marshall LL, Trethewie ER, Curtain CC: Chemical radiculitis. A clinical, physiological and immunological study. Clin Orthop 129:61-67, 1977.
18. Maruhashi J, Wright EB: Effect of oxygen lack on the single isolated mammalian (rat) nerve fiber. J Neurophysiol 30:434-452, 1967.
19. Maves TJ, Pechman PS, Gebhart GF, Meller ST: Possible chemical contribution from chromic gut sutures produces disorders of pain sensation like those seen in man. Pain 54:57-69, 1993.
20. McCarron RF, Wimpee MW, Hudkins PG, Laros GS: The inflammatory effect of nucleus pulposus. Spine 12:760-764, 1987.
21. Mixter WJ, Barr JS: Rupture of the intervertebral disc with involvement of the spinal canal. N Engl J Med 211:210-215, 1934.
22. Nachemson A: Intradiscal measurements of pH in patients with lumbar rhizopathies. Acta Orthop Scand 40:23-42, 1969.
23. Nussbaumer JC, Yanagisawa M, Otsuka M: Pharmacological properties of a C-fibre response evoked by saphenous nerve stimulation in an isolated spinal cord-nerve preparation of the newborn rat. Br J Pharmacol 98:373-382, 1989.
24. Smyth MJ, Wright V: Sciatica and the intervertebral disc. J Bone Joint Surg 40A: 1401-1418, 1958.
25. Steranak LR, Manning DC, DeHaas CJ, et al: Bradykinin as a pain mediator: Receptors are localized to sensory neurons, and antagonists have analgesic actions. Proc Natl Acad Sci USA 85:3245-3249, 1988.
26. Sugawara O, Atsuta Y, Iwahara T, et al: The effects of mechanical compression and hypoxia on nerve root and dorsal root ganglia. Spine 21:2089-2094, 1996.
27. Sunderland S: The function of nerve fibers whose structure has been disorganized. Anat Rec 109:503-509, 1951.
28. Torebjörk HE, Ochoa JL, McCann FV: Paresthesiae: Abnormal impulse generation in sensory nerve fibers in man. Acta Physiol Scand 105:518-520, 1979.
29. Urbán L, Somjen GG: Reversible effects of hypoxia on neurons in mouse dorsal root ganglia in vitro. Brain Res 520:36-42, 1990.
30. Wall PD, Devor M: Sensory afferent impulses originate from dorsal root ganglia as well as from the periphery in normal and nerve injured rats. Pain 17: 321-339, 1983.
31. Wright EB: The effects of asphyxiation and narcosis on peripheral nerve polarization and conduction. Am J Physiol 148:174-184, 1947.
32. Yaksh TL, Malmberg AB: Central Pharmacology of Nociceptive Transmission. In Wall PD, Melzack R (eds). Textbook of Pain. Ed 3. New York, Churchill Livingstone 165-200, 1994.