Gulf War Syndrome: Potential role of infectious diseases

Current Opinion in Infectious Diseases

Volumn 12, Issue 5, 1999, Pages 439-443

  Hyams, Kenneth C ^a,b  

^a NAVAL MEDICAL RESEARCH CENTER   (United States)

^b Naval Medical Center Annex   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBIOTIC AGENT; BROMIDE; CHEMICAL WARFARE AGENT; DOXYCYCLINE; IMMUNOGLOBULIN; INFLUENZA VACCINE; INSECT REPELLENT; PERTUSSIS VACCINE; PESTICIDE; PLAGUE VACCINE;

BIOLOGICAL WARFARE; CANADA; CLINICAL FEATURE; CORONAVIRUS; ENTEROBACTER INFECTION; EPIDEMIC MENINGITIS; GRAM NEGATIVE INFECTION; HUMAN; INFECTION; LEISHMANIASIS; MALARIA; MENTAL STRESS; ORAL DRUG ADMINISTRATION; PERSIAN GULF SYNDROME; PREVENTIVE MEDICINE; Q FEVER; RESPIRATORY TRACT INFECTION; REVIEW; SHIGELLOSIS; SOLDIER; SYNDROME DELINEATION; UNITED KINGDOM; UNITED STATES;

EID: 0032763244     PISSN: 09517375     EISSN: None     Source Type: Journal    
DOI: 10.1097/00001432-199910000-00005     Document Type: Review

References (51)

1. 1 Blank RR, Bell WH. Special reports: medical aspects of the Persian Gulf war. N Engl J Med 1991; 324:857-859.
2. 2 Gunby P. Environment adds to challenges facing Desert Shield physicians. JAMA 1991; 265:435-440.
3. 3 Lindsay GC, Dasey C. Operations Desert Shield/Storm infectious disease rates: a fortuitous anomaly. United States Army Medical Research and Development Command News. 5-6 February 1992.
4. 4 Gulflink.osd.mil. Medical surveillance during Operations Desert Shield/Desert Storm; November 6 1997; http: //www.gulflink.osd.mil/nfl.
5. 5 Writer JV, DeFraites RF, Brundage JF. Comparative mortality among US military personnel in the Persian Gulf region and worldwide during Operations Desert Shield and Desert Storm. JAMA 1996; 275:118-121.
6. 6 Persian Gulf Veterans Coordinating Board. Unexplained illnesses among Desert Storm veterans: a search for causes, treatment, and cooperation. Arch Intern Med 1995; 155:262-268.
7. 7 Penman AD, Currier MM, Tarver RS. No evidence of increase in birth defects and health problems among children born to Persian Gulf war veterans in Mississippi. Mil Med 1996; 161:1-6.
8. 8 Ciment J. Iraq blames Gulf war bombing for increase in child cancers. BMJ 1998; 317:1612.
9. 9 Robinson A. Veterans worry that unexplained medical problems are a legacy of service during the Gulf War. Can Med Assoc J 1995; 152:944-947.
10. 10 Joseph SC and the Comprehensive Clinical Evaluation Program Evaluation Team. A comprehensive clinical evaluation of 20000 Gulf War veterans. Mil Med 1997; 1997; 162:149-155. Clinical findings from the systematic examination of US Gulf War veterans are provided.
11. 11 Coker WJ, Bhatt BM, Blatchley NF, Graham JT. Clinical findings from the first 1000 Gulf war veterans in the Ministry of Defence's medical assessment programme. BMJ 1999; 318:290-294. Clinical findings from the systematic examination of British Gulf War veterans are provided.
12. 12 Murphy FM, Allen RE, Kang H, Mather SH, Dalager NA, Kizer KW, Lee KY. The health status of Gulf War veterans: lessons learned from the Department of Veterans' Affairs Health Registry. Mil Med 1999; 164:327-331.
13. 13 Department of Defense. Comprehensive clinical evaluation program for Gulf War veterans: CCEP report on 18598 participants. Washington, DC: Office of the Assistant Secretary of Defense for Health Affairs Clinical Services; 1996.
14. 14 Parliamentary Office of Science and Technology. Gulf War illnesses: dealing with the uncertainties; London: HMSO; 1997. This report includes a comprehensive assessment of Gulf War health issues by the British Parliament.
15. 15 Persian Gulf Veterans Coordinating Board Research Working Group. Annual report to Congress 1998: research on Gulf War veterans' illnesses. Washington, DC: Department of Veterans' Affairs; 1999.
16. 16 Gray GC, Coate BD, Anderson CM, Kang HK, Berg SWH, Wignall FS, et al. The postwar hospitalization experience of US veterans of the Persian Gulf War. N Engl J Med 1996; 335:1505-1513.
17. 17 Cowan DN, DeFraites RF, Gray GC, Goldenbaum MB, Wishil SM. A records-based evaluation of the risk of birth defects among children of Gulf war veterans. N Engl J Med 1997; 336:1650-1656.
18. 18 Kang HK, Bullman TA. Mortality among US. veterans of the Persian Gulf War. N Engl J Med 1996; 335:1498-504. This article provides mortality data on the entire population of US Gulf War veterans for the 30 months following the Gulf War.
19. 19 The Iowa Persian Gulf Study Group. Self-reported illness and health status among Gulf war veterans. JAMA 1996; 277:238-245.
20. 20 Fukuda K, Nisenbaum R, Stewart G, Thompson WW, Robin L, Washko RM. Chronic multisymptom illness affecting Air Force veterans of the Gulf War. JAMA 1998; 280:981-988.
21. 21 Goss Gilroy Inc and cooperation with Department of National Defence. Health Study of Canadian forces personnel involved in the 1991 conflict in the Persian Gulf. Ottawa, Ontario: Goss Gilroy Inc; 1998. This is a survey of all Canadian Gulf War veterans based on self-reported data.
22. 22 Unwin C, Blatchley N, Coker W, Ferry S, Hotopf M, Hull L, et al. The health of United Kingdom servicemen who served in the Persian Gulf War. Lancet 1999; 353:169-178. The most comprehensive epidemiological survey of British Gulf War veterans is reported.
23. 23 Haley RW, Horn J, Roland PS, Wilson W, Bryan WW, Van Ness PC, et al. Evaluation of neurologic function in Gulf war veterans: a blinded case-control study. JAMA 1997; 277:223-230.
24. 24 Department of Veterans' Affairs. VA Persian Gulf Expert Scientific Committee Report (19 February 1996). Washington, DC: Department of Veterans Affairs; 1996.
25. 25 Department of Defense. Report of the Defense Science Board Task Force on Persian Gulf War Health Effects, June 1994. Washington, DC: Office of the Under Secretary of Defense for Acquisition and Technology; 1994.
26. 26 National Institutes of Health Technology Assessment Workshop Panel. The Persian Gulf Experience and Health. JAMA 1994; 272:391-395. This is an important early review of Gulf War health issues by an independent panel.
27. 27 Institute of Medicine. Health consequences of service during the Persian Gulf war: recommendations for research and information systems. Washington, DC: National Academy Press; 1996.
28. 28 Institute of Medicine, Division of Health Promotion and Disease Prevention, Committee on the DoD Persian Gulf Syndrome Comprehensive Clinical Evaluation Program. Evaluation of the US Department of Defense Persian Gulf Comprehensive Clinical Evaluation Program. Washington, DC: National Academy Press; 1996.
29. 29 Presidential Advisory Committee on Gulf War Veterans' Illnesses: final report. Washington, DC: US Government Printing Office, 1996.
30. 30 Silver FT. IoM takes 'comprehensive' approach to PGI. US Med 1999; 35:20-26.
31. 31 Joseph SC, Hyams KC, Gackstetter GD, Mathews EC, Patterson RE. Persian Gulf War health issues. In: Rom WN (editor). Environmental and occupational medicine. 3rd edn. Philadelphia: Lippincott-Raven Publishers; 1998.
32. 32 Quin NE. The impact of diseases on military operations in the Persian Gulf. Military Med 1982; 147:728-734.
33. 33 Hyams KC, Hanson K, Wignall FS, Escamilla J, Oldfield EC. The impact of infectious diseases on the health of US troops deployed to the Persian Gulf during Operations Desert Shield and Desert Storm. Clin Infect Dis 1995; 20:1497-1504. This article provides a comprehensive review of endemic infectious disease threats during the Gulf War deployment.
34. 34 Richards AL, Malone JD, Sheris S, et al. Arbovirus and rickettsial infections among combat troops during Operation Desert Shield/Desert Storm. J Infect Dis 1993; 168:1080-1081.
35. 35 Magill AJ, Grogl M, Gasser RA, Sun W, Oster CN. Visceral infection caused by Leishmania tropica in veterans of Operation Desert Storm. N Engl J Med 1993; 328:1383-1387.
36. 36 Kreutzer RD, Grogl M, Neva FA, Fryauff DJ, Magill AJ, Aleman-Munoz MM. Identification and genetic comparison of leishmanial parasites causing viscerotropic and cutaneous disease in soldiers returning from Operation Desert Storm. Am J Trop Med Hyg 1993; 49:357-363.
37. 37 Committee on Veterans' Affairs, United States Senate. Report of the Special Investigation Unit on Gulf War illnesses. Washington, DC: US Government Printing Office.
38. 38 Nicolson GL, Rosenberg-Nicolson NL. Doxycycline treatment and Desert Storm. JAMA 1995; 273:618-619.
39. 39 Nicolson GL, Nicolson NL. Gulf War illnesses: complex medical, scientific and political paradox. Med Conflict Surv 1998; 14:156-165.
40. 40 Gray GC, Kaiser KS, Hawksworth AW, Watson HL. No serologic evidence of an association found between Gulf War service and Mycoplasma fermentans infection. Am J Trop Med Hyg 1999; 60:752-757.
41. 41 Graham JT. Updates: Gulf health research. J Royal Naval Med Serv 1998; 84:3-7.
42. 42 White CS, Adler WH, McGann VG. Repeated immunization: possible adverse effects. Reevaluation of human subjects at 25 years. Ann Intern Med 1974; 81:594-600.
43. 43 Hyams KC, Wignall FS, Roswell R. War syndromes and their evaluation: from the US Civil War to the Persian Gulf War: Ann Intern Med 1996; 125:398-405.
44. 44 Cotton T, Lewis T, Thiele FH. A note on the 'irritable heart' of soldiers. Br Med J 1915; 1:722.
45. 45 Southern PM, Patel S, Gander RM. Does examination of urinary sediment identify individuals with Gulf War syndrome? A pilot study. Am J Med Sci 1998; 315:225-229.
46. 46 Deming QB, Hyman ES, Southern PM. Urinary sediment examination and Gulf War syndrome [letter]. Am J Med Sci 1998; 316:411-413.
47. 47 Sargent F. An experiment with orange-red underwear. Texas Rep Biol Med 1974; 32:157-171.
48. 48 Ellis FP. Hot-climate fatigue in the Royal Navy: a review of lay opinion. Lancet 1952; 2:527-531.
49. 49 Lorber B. Are all diseases infectious? Ann Intern Med 1996; 125:844-851.
50. 50 United States General Accounting Office. Gulf War illnesses: questions about the presence of squalene antibodies in veterans can be resolved. GAO/NSIAD-99-5; 1999. This is a US General Accounting Office review of a hypothesis that an experimental adjuvant, squalene, could be a cause of unexplained illnesses among Gulf War veterans.
51. 51 United States General Accounting Office. Medical readiness: safety and efficacy of the anthrax vaccine. GAO/T-NSIAD-99-148; 1999. This is a US General Accounting Office report about the current anthrax vaccine. The evaluation concluded that the long-term safety of the vaccine had not been studied. Current Opinion in Infectious Diseases 1999, 12:447-457