Cardiovascular and renal effects of central administration of a mineralocorticoid receptor antagonist in conscious female rats

European Journal of Pharmacology

Volumn 385, Issue 2-3, 1999, Pages 199-202

  Rahmouni, Kamal ^a   Barthelmebs, Mariette ^a   Grima, Michèle ^a,b   Imbs, Jean Louis ^a,b   De Jong, Wybren ^a  

^a UNIVERSITÉ DE STRASBOURG   (France)

^b INSTITUT DE RECHERCHES INTERNATIONALES SERVIER   (France)

Author keywords

Blood pressure; Brain; Female rat; Mineralocorticoid receptor; Renal function; RU28318

Indexed keywords

MINERALOCORTICOID RECEPTOR; OXPRENOATE POTASSIUM;

ANIMAL EXPERIMENT; ARTICLE; BLOOD PRESSURE REGULATION; CONTROLLED STUDY; DRUG EFFECT; FEMALE; HEART RATE; HYPERTENSION; INTRACEREBROVENTRICULAR DRUG ADMINISTRATION; KIDNEY FUNCTION; NONHUMAN; PRIORITY JOURNAL; RAT; SYSTOLIC BLOOD PRESSURE; URINARY EXCRETION;

ALDOSTERONE ANTAGONISTS; ANIMALS; BLOOD PRESSURE; CARDIOVASCULAR PHYSIOLOGY; CHLORIDES; CONSCIOUSNESS; FEMALE; HEART RATE; INJECTIONS, INTRAVENTRICULAR; KIDNEY; MALE; POTASSIUM; RATS; RATS, WISTAR; RECEPTORS, MINERALOCORTICOID; SODIUM; SPIRONOLACTONE; SYSTOLE; URINATION;

EID: 0032763211     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-2999(99)00705-0     Document Type: Article

References (14)

1. Bachman J., Feldmer M., Ganten U., Stock G., Ganten D. Sexual dimorphism of blood pressure: possible role of the renin-angiotensin system. J. Steroid Biochem. Mol. Biol. 40:1991;511-515.
2. Cambotti L.J., Cole F.E., Gerall A.A., Frohlich E.D., MacPhee A.A. Neonatal gonadal hormones and blood pressure in the spontaneously hypertensive rat. Am. J. Physiol. 247:1984;E258-E264.
3. Crofton J.T., Share L. Gonadal hormones modulate deoxycorticosterone-salt hypertension in male and female rats. Hypertension. 29:1997;494-499.
4. DiBona G., Kopp U.C. Neural control of renal function. Physiol. Rev. 77:1997;75-197.
5. Gomez-Sanchez E., Fort C., Thwaites D. Central mineralocorticoid receptor antagonism blocks hypertension in Dahl S/JR rats. Am. J. Physiol. 262:1992;E96-E99.
6. Handa R.J., Burgess L.H., Kerr J.E., O'Keefe J.A. Gonadal steroid hormone receptors and sex differences in the hypothalamo-pituitary-adrenal axis. Horm. Behav. 28:1994;464-476.
7. Lange D.L., Haywood J.R., Hinojosa-Laborde C. Role of the adrenal medullae in male and female DOCA-salt hypertensive rats. Hypertension. 31:1998;403-408.
8. Le Mevel J.C., Abitbol S., Beraud G., Maniey J. Dynamic changes in plasma adrenocorticotrophin after neurotropic stress in male and female rats. J. Endocrinol. 76:1978;359-360.
9. Ouchi Y., Share L., Crofton J.T., Iitake K., Brooks D.P. Sex difference in the development of deoxycorticosterone-salt hypertension in the rat. Hypertension. 9:1987;172-177.
10. Rahmouni K., Barthelmebs M., Grima M., Imbs J.L., De Jong W. Intervention des récepteurs centraux aux mineralocorticoid dans le contrôle de la pression artérielle du rat normotendu conscient. Arch. Mal. Coeur Vaiss. 91:1998;1009-1012.
11. Rahmouni K., Barthelmebs M., Grima M., Imbs J.L., De Jong W. Brain mineralocorticoid receptor control of blood pressure and kidney function in normotensive rats. Hypertension. 33:1999;1201-1206.
12. Tang F. Effect of sex and age on serum aldosterone and thyroid hormones in the laboratory rat. Horm. Metab. Res. 17:1985;507-509.
13. Turner B.B. Sex differences in the binding of type I and type II corticosteroid receptors in rat hippocampus. Brain Res. 581:1992;229-236.
14. Weinstock M., Razin M., Schorer-Apelbaum D., Men D., McCarty R. Gender differences in sympathoadrenal activity in rats at rest and in response to footshock stress. Int. J. Dev. Neurosci. 16:1998;289-295.