Albumin possesses intrinsic enolase activity towards dihydrotestosterone which can differentiate benign from malignant breast tumors

Anticancer Research

Volumn 19, Issue 5 B, 1999, Pages 4113-4124

  Drmanovic, Zoran ^a   Voyatzi, Sultana ^a   Kouretas, Demetrios ^b   Sahpazidou, Despina ^a   Papageorgiou, Athanasios ^a   Antonoglou, Orpheus ^a  

^a THEAGENIO CANCER HOSPITAL   (Greece)

^b UNIVERSITY OF THESSALY   (Greece)

Author keywords

Albumin; Breast tumors; Dihydrotestosterone (DHT); Enolase activity

Indexed keywords

ALBUMIN; ANDROSTANOLONE; COPPER ION; ENOLASE; HISTIDINE; NICKEL; SERUM ALBUMIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BREAST CANCER; BREAST TUMOR; CONTROLLED STUDY; CYTOSOL; DIFFERENTIAL DIAGNOSIS; ENZYME ACTIVITY; HUMAN; HUMAN TISSUE; MALE; MOUSE; NONHUMAN; PH; PRIORITY JOURNAL;

EID: 0032762665     PISSN: 02507005     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (29)

1. Wilson WD and Foster JF: Conformation-dependent limited proteolysis of bovine plasma albumin by an enzyme present in commercial albumin preparations. Biochemistry 10: 1772-1780, 1971.
2. Anai M, Haraguchi H and Takagi X: An endonuclease associated with bovine plasma albumin. J Biol Chem 247: 193-198, 1972.
3. Trujillo L-E, Castellanos L, Garcia O, Herrera L: A protocol for the purification of bovine serum albumin free of deoxyribonuclease activity. Biotechniques 9: 620-622, 1990.
4. Elsbach P, Pettis P: Phospholipase activity associated with serum albumin. Biochim Biophys Acta 296: 89-93, 1973.
5. Ganaphathy V, Fonteles M, Pashey DH, Leibach FH: Prolidase contamination in commercial bovine serum albumin. Biochim Biophys Acta 719: 154-157, 1982.
6. Kurooka S, Yoshimura Y: Mercaptoethanol release upon interaction of s-lauroylmercaptoethanol with serum albumin. J Biochem 74: 785-795, 1973.
7. Dieter P, Krause H, Schulze Specking A: Arachidonate metabolism in macrophages is affected by albumin. Eicosanoids 3: 45-51, 1990.
8. Kurono Y, Miyajima M, Tsuji T, Yano T, Takeuchi T, Ikeda K: Esterase-like activity of human serum albumin VII. Reaction with p-nitrophenyl 4-guanidino-benzoate. Chem Pharm Bull 39: 1292-1294, 1991.
9. Ho JX, Holowachuk EN, Norton EJ, Twigg PD, Carter DC: X-ray and primary structure of horse serum albumin (equus caballus) at 0.27 nm resolution. Eur J Biochem 215: 205-212, 1993.
10. Kouretas D, Voyatzi S, Sahpazidou D, Lazopoulos K, Antonoglou O: Enzymatic conversion of dihydrotestosterone from 3-keto to 3-enol form in the rat prostate. Anticancer Res 16: 2843-2848, 1996.
11. Lea OA, Thorsen T, Kvinusland S : Extracellular proteins in breast tumor cytosol. Anticancer Res 7: 113-117, 1987.
12. Soreide JA, Lea OA, Kvinusland S: Cytosol albumin content in operable breast cancer. Correlations to steroid hormone receptors, other prognostic factors and prognosis. Acta Oncol 30: 797-802, 1991.
13. Soreide JA, Lea OA, Kvinusland S: Progesterone-binding cyst protein (PBCP=GCDFP-24) and steroid hormone receptors as markers of differentiation in breast cancer. Inverse relation of distribution in normal and malignant tissue of the same breast. Anticancer Res 11: 1323-1326, 1991.
14. Zeginiadou T, Koliais S, Kouretas D, Antonoglou O: Nonlinear-binding of sex steroids to albumin and sex hormone binding globulin. Eur J Drug Metab Pharmacokinet 22: 229-235, 1997.
15. Crambach A, Jovin TM, Svedsen PJ, Rodbard D: Analytical and preparative polyacrylamide gel electrophoresis and objectively defined fractionation route apparatus and procedures. In: Methods of protein separation (Edited by N Catsimpoolas). Plenum Publishing Corp. New York, 1976, Vol 2, p27.
16. Smith BJ: SDS polyacrylamide electrophoresis. In: Methods in Molecular Biology (Edited by J Walker). Humana Press, Clifton N.J. 1984, Vol 1, pp 41-56.
17. Bradford A: Rapid and sensitive method for the quantification of microgram quantities of protein utilizing the principle of protein dye-binding. Analyt Biochem 72: 248-254, 1976.
18. Zeginiadou T, Kortsaris AH, Koliais S, Antonoglou O: Sex hormone binding globulin inhibits strongly the uptake of estadiol by human breast carcinoma cells via a deprivative mechanism. Cancer Biochem Biophys 16: 253-263, 1998.
19. Decock-Le, Reverend B, Perly B, Sarkar B: Isolation and two dimensional 1H- NMR of peptide [1-24] of dog serum albumin and studies of its complexation with copper and nickel by NMR and CD spectroscopy. Biochim Biophys Acta 912: 16-27, 1987.
20. Richieri GV, Anel A, Kleinfeld AM: Interaction of long-chain fatty acids and albumin: determination of free fatty acid levels using the fluorescent probe ADIFAB. Biochemistry 32: 7574-7580, 1993.
21. Deliconstantinos G, Tsopanakis G, Karayiannakos P, Skalkeas G: Evidence for the existence of non-esterified cholesterol carried by albumin in rat serum. Atherosclerosis 61: 67-75, 1986.
22. Dzhafarov ES: Study on the structure of human serum albumin, liberated from fatty acids, by tritium marker method. Mol Biol 26: 168-172, 1992.
23. Dzhafarov ES: Conformational transitions of human serum depending on pH. Study using tritium markers. Mol Biol 25: 1412-1417, 1992.
24. Watanabe S, Tani T, Watanabe S, Seno M: Effects of free fatty acids on the binding of steroid hormones to bovine serum albumin. Lipids 25: 633-638, 1990.
25. Watanabe S, Tani T, Watanabe S, Seno M: Transport of steroid hormones facilitated by serum proteins. Biochim Biophys Acta 1073: 275-284, 1991.
26. Fisher MJ, Bos OJ, van der Linden RF, Wilting J, Janssen LH: Steroid binding to human serum albumin and fragments thereof. Role of protein conformation and fatty acid content. Biochem Pharmacol 45: 2411-2416, 1993.
27. Singh A, Blench I, Morris HR, Savoy LA, Reed MJ: Synergistic interaction of growth factors and albumin in regulating estradiol synthesis in breast cancer cells. Mol Cell Endocrinol 85: 165-173, 1992.
28. Singh A, Ghilchik MW, Patel SR, Blench I, Morris HR, Reed MJ: Identification of albumin in breast tumor cytosol as a factor involved in the stimulation of estradiol 17 beta-hydroxysteroid dehydrogenase (reductive) activity. Mol Cell Endocrinol 83: 85-92, 1992.
29. Germain P, Harbrioux G: Modulation of the estradiol 17-beta mitogenic effect on human breast cancer MCF-7 cells by serum albumin in defined medium. Anticancer Res 13: 1581-1585, 1993.