Biomolecular-chemical screening. A novel screening approach for the discovery of biologically active secondary metabolites. I. Screening strategy and validation

Journal of Antibiotics

Volumn 52, Issue 11, 1999, Pages 945-951

  Maier, Armin ^a   Maul, Corinna ^a   Zerlin, Marion ^a   Sattler, Isabel ^a   Grabley, Susanne ^a   Thiericke, Ralf ^a  

^a HANS KNÖLL INSTITUTE   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CHELERYTHRINE; DACTINOMYCIN; DNA; DOXORUBICIN; DRUG; ERYTHROMYCIN; GLUCOSE; NOGALAMYCIN; PENICILLIN G;

ARTICLE; DRUG BINDING; DRUG DNA BINDING; DRUG SCREENING; MACROMOLECULE; MOLECULAR BIOLOGY; PRIORITY JOURNAL; THIN LAYER CHROMATOGRAPHY;

EID: 0032762483     PISSN: 00218820     EISSN: None     Source Type: Journal    
DOI: 10.7164/antibiotics.52.945     Document Type: Article

References (14)

1. BROACH, J. R. & J. THORNER: High throughput screening for drug discovery. Nature 384 Suppl.: 14-16, 1996
2. FIEDLER, H.-P: Biosynthetic capacities of actinomycetes. 1. Screening for secondary metabolites by HPLC and UV-visible absorbance spectral libraries. Nat. Prod. Lett. 2: 119-128, 1993
3. GRABLEY, S.; R. THIERICKE & A. ZEECK: The chemical screening approach. In Drug Discovery from Nature. Eds., S. GRABLEY, et al., pp. 124-148, Springer-Verlag, Heidelberg, 1999
4. BURKHARDT, K.; H.-P. FIEDLER, S. GRABLEY, R. THIERICKE & A. ZEECK: New cineromycins and muscacins obtained by metabolite pattern analysis of Streptomyces griseoviridis (FH-S 1832). I. Taxonomy, fermentation, isolation and biological activity. J. Antibiotics 49: 432-437, 1996
5. ZÄHNER, H.; H. DRAUTZ & W. WEBER: Novel approaches to metabolite screening. In Bioactive Microbial Products: Search and Discovery. Eds., J. D. BU'LOCK, et al., pp. 51-70, Academic Press London, 1982
6. KOCH, C.; T. NEUMANN, R. THIERICKE & S. GRABLEY: A central natural product pool - New approach in drug discovery strategies. In Drug Discovery from Nature. Eds., S. GRABLEY, et al., pp. 51-55, Springer-Verlag, Heidelberg, 1999
7. MAIER, A.; C. MAUL, M. ZERLIN, S. GRABLEY & R. THIERICKE: Biomolecular-chemical screening. A novel screening approach for the discovery of biologically active secondary metabolites. II. Application studies with pure metabolites. J. Antibiotics 52: 952-959, 1999
8. MAUL, C.; I. SATTLER, M. ZERLIN, C. HINZE, C. KOCH, A. MAIER, S. GRABLEY & R. THIERICKE: Biomolecular-chemical screening. A novel screening approach for the discovery of biologically active secondary metabolites. III. New DNA-binding metabolites. J. Antibiotics Manuscript submitted
9. HENNE, P., R. THIERICKE, S. GRABLEY, K. HÜTTER, J. WINKE, E. JURKIEWICZ & A. ZEECK: Secondary metabolites by chemical screening. Part 23. Waraterpols, new Penicillium metabolites and their derivatives. Liebigs Ann. Chem. 1993: 565-571, 1993
10. IVANOV, V. I.; L. E. MINCHENKOVA, A. K. SCHYOLKINA & A. I. POLETAYEV: Different conformations of double-stranded nucleic acid in solution as revealed by circular dichroism. Biopolymers 12: 89-110, 1973
11. CHATTERJEE, S.; E. K. VIJAYAKUMAR, C. M. FRANCO, R. MAURYA, J. BLUMBACH & B. M. GANGULI: Phencomycin, a new antibiotic from a Streptomyces species HIL Y-9031725. J. Antibiotics 48: 1353-1354, 1995
12. HAYAKAWA, Y.; K. ISHIGAMI, K. SHIN-YA & H. SETO: Menoxymycins A and B antitumor antibiotics generating active oxygen in tumor cells. J. Antibiotics 47: 1344-1347, 1994
13. MIYAO, H.; Y. SAKAI, T. TAKESHITA, Y. Ito, J. KINJO & T. NOHARA: Triterpene saponins from Abrus cantoniensis (Leguminosae). II. Characterization of six new saponins having a branched-chain sugar. Chem. Pharm. Bull. 44: 1228-1231, 1996
14. SKOWRONSKI, R. & D. FELDMAN: Characterization of an estrogen-binding protein in the yeast Candida albicans. Endocrinology 124: 1965-1972, 1989