Effects of long-term use of testosterone enanthate. II. Effects on lipids, high and low density lipoprotein cholesterol and liver function parameters

International Journal of Andrology

Volumn 22, Issue 6, 1999, Pages 347-355

  Tyagi, Alpana ^a   Rajalakshmi, M ^a   Jeyaraj, D Antony ^a   Sharma, R S ^a   Bajaj, J S ^a  

^a ALL INDIA INSTITUTE OF MEDICAL SCIENCES   (India)

Author keywords

HDL cholesterol; LDL cholesterol; Liver transaminases; Monkey; Testosterone enanthate

Indexed keywords

ALKALINE PHOSPHATASE; AMINOTRANSFERASE; ANDROGEN; BILIRUBIN; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; LIPID; LOW DENSITY LIPOPROTEIN CHOLESTEROL; TESTOSTERONE ENANTATE; TRIACYLGLYCEROL;

ALKALINE PHOSPHATASE BLOOD LEVEL; AMINOTRANSFERASE BLOOD LEVEL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BILIRUBIN BLOOD LEVEL; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; DIET; INTRAMUSCULAR DRUG ADMINISTRATION; LIPID BLOOD LEVEL; LIVER FUNCTION; LONG TERM CARE; MALE; NONHUMAN; PRIORITY JOURNAL; RHESUS MONKEY; TESTOSTERONE BLOOD LEVEL; TRIACYLGLYCEROL BLOOD LEVEL;

ALANINE TRANSAMINASE; ANIMALS; ASPARTATE AMINOTRANSFERASES; BODY WEIGHT; CHOLESTEROL; CHOLESTEROL, HDL; CHOLESTEROL, LDL; CONTRACEPTIVE AGENTS, MALE; LIPIDS; LIVER; LIVER FUNCTION TESTS; MACACA MULATTA; MALE; TESTOSTERONE; TIME FACTORS; TRIGLYCERIDES;

EID: 0032762207     PISSN: 01056263     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2605.1999.00190.x     Document Type: Article

References (49)

1. Agnew, L. R. C. & Gardner, W. U. (1952) The incidence of spontaneous hepatomas in C3H, C3H (low milk factor), and CBA mice and the effect of estrogen and androgen on the occurrence of these tumors in C3H mice. Cancer Research 12, 757-761.
2. Anderson, R. A., Wallace, E. M. & Wu, F. C. W. (1995) Effect of testosterone enanthate on serum lipoproteins in man. Contraception 52, 115-119.
3. 2-cholesterol. Metabolism 43, 935-939.
4. Bagatell, C. J., Knopp, R. H., Rivier, J. E. & Bremner, W. J. (1994) Physiological levels of estradiol stimulate plasma high density lipoprotein 2-cholesterol levels in normal men. Journal of Clinical Endocrinology and Metabolism 78, 855-861.
5. Bajaj, J. S., Rajalakshmi, M. & Madan, R. (1989) Metabolic effects of contraceptive steroids. In: Safety Requirements for Contraceptive Steroids (Ed. F. Michal), pp. 360-384. Cambridge University Press, New York.
6. Bardin, C. W., Swerdloff, R. S. & Santen, R. J. (1991) Androgens: risks and benefits. Journal of Clinical Endocrinology and Metabolism 73, 4-7.
7. Barrett-Connor, E. (1995) Androgens, lipids and atherosclerosis. In: Pharmacology, Biology and Clinical Applications of Androgens (Eds S. Bhasin, R. S. Swerdloff, C. Wang, H. Gabelnick & J. Spieler) Wiley, New York.
8. Behre, H. M. & Nieschlag, E. (1992) Testosterone buciclate (20-Aet-1) in hypogonadal men: Pharmacokinetics and pharmacodynamics of the new long-acting androgen ester. Journal of Clinical Endocrinology and Metabolism 75, 1204-1210.
9. Bergmeyer, H. U., Bowers, G. N., Horder, M. & Moss, D. W. (1977) Provisional recommendation on IFFC methods for the measurement of catalytic concentrations of enzymes. Clinical Chemistry 23, 887-889.
10. Bhasin, S., Swerdloff, R. S., Steiner, B., Peterson, M. A., Meridores, T., Galmirini, M., Pandian, M. R., Goldberg, R. & Berman, N. (1992) A. biodegradable testosterone microcapsule formulation provides uniform eugonadal levels of testosterone for 10-11 weeks in hypogonadal men. Journal of Clinical Endocrinology and Metabolism 74, 75-84.
11. Deutsche Gesellschaft fur klinische Chemie (DGKC) (1972) Journal of Clinical Chemistry and Clinical Biochemistry 10, 182.
12. Firminger, H. I. & Reuber, M. D. (1961) Influence of adrenocortical, androgenic and anabolic hormones on the development of carcinoma and cirrhosis of the liver in AXC rats fed N-2-fluorenyldiacetamide. Journal of National Cancer Institute 27, 559-595.
13. Friedl, K. E., Hannan, C. J., Jones, R. E. & Plymate, S. R. (1990) High-density lipoprotein cholesterol is not decreased if an aromatizable androgen is administered. Metabolism 39, 69-74.
14. Godsland, I. F., Wynn, V., Crook, D. & Miller, N. E. (1987) Sex, plasma lipoproteins, and atheroscleosis: Prevailing assumptions and outstanding questions. American Heart Journal 114, 1467-1503.
15. Goldberg, R. B., Rabin, D., Alexander, A. N., Doelle, G. C. & Getz, G. S. (1985) Suppression of plasma testosterone leads to an increase in serum total and high density lipoprotein cholesterol and apoproteins A-1 and B. Journal of Clinical Endocrinology and Metabolism 60, 203-207.
16. Gordon, T., Castelli, W. P., Hjortland, M. C., Kannel, W. B. & Dawber, T. R. (1977) High density lipoprotein as a protective factor against coronary artery disease. The Framingham study. American Journal of Medicine 62, 707-714.
17. Haffner, S. M., Kushwaha, R. S., Foster, D. M., Applebaum-Bowden, D. & Hazzard, W. R. (1983) Studies on the metabolic mechanism of reduced high density lipoproteins during anabolic steriods therapy. Metabolism 32, 413-420.
18. Handelsman, D. J., Conway, A. J. & Boylan, L. M. (1992) Suppression of human spermatogenesis by testosterone implants. Journal of Clinical Endocrinology and Metabolism 75, 1326-1332.
19. International Federations of Clinical Chemistry Scientific Committee. (1980) Journal of Clinical Chemistry and Clinical Biochemistry 18, 525-534.
20. Jacobs, N. J. & Van Demark, P. J. (1960) The purification and properties of the glycerophosphate oxidizing enzyme of Streptococcus faccalies. 10 CI. Archives of Biochemistry and Biophysics 88, 250-255.
21. Kirkland, R. T., Keenan, B. S., Probbbstfield, J. L., Patsch, W., Lin, T. L. & Clayton, G. W. (1987) Decrease in plasma high density lipoprotein cholesterol levels at puberty in boys with delayed adolescence. Journal of the American Medical Association 257, 502-507.
22. Laskarzewski, P. M., Morrison, J. A., Gutai, J., Orchard, T., Khoury, P. R. & Glueck, C. J. (1983) High and low density lipoprotein cholesterols in adolescent boys: Relationships with endogenous testosterone, estradiol, and quetelet index. Metabolism 32, 262-271.
23. Lipid Research Clinics Coronary Primary Prevention Trial Results. 11. (1984) The relationship of reduction in incidence of coronary heart disease to cholesterol lowering. Journal of the American Medical Association 25, 365-374.
24. Lopes-Virella, M. F., Stone, P., Ellis, S. & Colwell, J. A. (1977) Cholesterol determination in high density lipoprotein separated by three different methods. Clinical Chemistry 23, 882-884.
25. Mastroianni, L. Jr & Manson, W. A. Jr (1963) Collection of monkey semen by electrocjaculation. Proceedings of the Society of Experimental Biology and Medicine 112, 1025-1027.
26. Miller, G. J., Alexis, S. D., Beckless, G. L. A. & Byam, N. T. A. (1982) Serum lipoproteins and susceptibility of men of Indian descent to coronary heart disease. Lancet 2, 202-203.
27. Miller, G. J. & Miller, N. E. (1975) Plasma high density lipoprotein concentration and development of ischaemic heart disease. Lancet 1, 16-19.
28. Moore, M. R., Drinkwater, N. R., Miller, E. C., Miller, J. A. & Pilot, H. C. (1981) Quantitative analysis of the time-dependent development of glucose-6-phosphatase-dehcient foci in the livers of mice treated neonatally with diethylnitrosamine. Cancer Research 41, 1585-1593.
29. Nieschlag, E., Behre, H. M. & Weinbauer, G. F. (1992) Hormonal male contraception: a real chance? In: Spermatogenesis-Fertilization-Contraception: Molecular, Cellular and Endocrine Events in Male Reproduction (Eds E. Nieschlag & U. F. Halbernicht), pp. 477-501. Springer, Heidelberg.
30. Plymate, S. R. & Swerdloff, R. S. (1992) Androgens, Lipids, and Cardiovascular Risk. Annals of Internal Medicine 117, 871-872.
31. Rajalakshmi, M. & Ramakrishnan, P. R. (1989) Pharmacokinetics and pharmacodynamics of a new long-acting androgen ester: Maintenance of physiological levels for 4 months after a single injection. Contraception 40, 399-412.
32. Siedel, J., Hagele, E. O., Ziegenhorn, J. & Wahlefeld, A. W. (1983) Reagent for the enzymatic determination of serum total cholesterol with improved lipolytic efficiency. Clinical Chemistry 29, 1075-1081.
33. Sivashannnigani, P. & Rajalakshmi, M. (1997) Sperm maturation in rhesus monkey: changes in ultrastructure, chromatin condensation and lipid bilayer. Anatomical Record 247, 25-32.
34. Sorva, R., Kussi, T., Dunkel, L. & Taskinen, M. R. (1988) Effects of endogenous sex steroids on serum lipoproteins and post-heparin plasma lipolytic enzymes. Journal of Clinical Endocrinology and Metabolism 66, 408-413.
35. Swerdloff, R. S., Palacios, A., McClure, R. D., Campfield, L. A. & Brosman, S. A. (1977) Clinical evaluation of testosterone enanthate in the reversible suppression of spermatogenesis in the human male: Efficacy, mechanism of action and adverse effects. In: Hormonal Control of Male Fertility, (Ed. D. J. Patanelli), pp. 41-68. US Department of Health, Education and Welfare, Publication no. (NIH) 78-1097, Washington.
36. Swerdloff, R. S., Wang, C. & Bhasin, S. (1989) Male Contraception: 1988 and beyond. In: The Testis (Eds H. G. Burger & D. M. de Kretser), 2nd edn, pp. 547-568. New York, Raven Press.
37. Thompson, P. D., Cullinane, E. M., Sady, S. P., Chenevert, C., Saritelli, A. L., Sady, M. A. & Herbert, P. N. (1989) Contrasting effects of testosterone and stanozolol on serum lipoprotein levels. Journal of the American Medical Association 261, 1165-1168.
38. Tikkanen, M. J. & Nikkila, E. A. (1987) Regulation of hepatic lipase and serum lipoprotein by sex steroids. American Heart Journal 113, 562-567.
39. Toh, Y. C. (1981) Effect of neonatal castration on liver tumor induction by N-2-fluornylacetamide in suckling BALB/c mice. Carcinogenesis (Lond.) 2, 1219-1221.
40. Vesselinovitch, S. D., Ltze, L., Mihailovich, N. & Rao, K. V. N. (1980) Modifying role of partial hepatectomy and gonadectomy in ethylnitrosourea-induced hepatocarcinogenesis. Cancer Research 40, 1538-1542.
41. Vesselinovitch, S. D. & Mihailovich, N. (1967) The effects of gonadectomy on the development of hepatomas induced by urethan. Cancer Research 27, 1788-1791.
42. Waites, G. M. H. (1993) Male fertility regulation: The challenges for the year 2000. British Medical Bulletin 48, 210-221.
43. Weinbauer, S. F., Marshall, G. R. & Nieschlag, E. (1986) New injectable testosterone ester maintains serum testosterone of castrated monkeys in the normal range for four months. Acta Endocrinologica 29, 443-465.
44. Wu, F. C. W. (1988) Male contraception: current status and future prospects. Clinical Endocrinology 29, 443-465.
45. Wu, F. C. W., Farley, T. M. M., Peregoudov, A. & Waites, G. M. H. (1996) Effects of testosterone enanthate in normal men: Experience from a multicentre contraceptive efficacy study. World Health Organization Task Force on methods for the regulation of male fertility. Fertility and Sterility 65, 626-636.
46. Yu, M. W. & Chen, C. J. (1993) Elevated serum testosterone levels and risk of hepatocellular carcinoma. Cancer Research 53, 790-794.
47. Yu, M. W., Tsai, S. F., Hsu, K. H. & You, S. L. (1988) Epidemiologic characteristics of malignant neoplasma in Taiwan. II. Liver cancer. Journal of National Public Health Association 8, 125-138.
48. Zgliczynski, S., Ossowski, M., Slowinska-Srzednicka, J., Przezinska, A., Zgliczynski, W., Soszynski, P., Chotkowska, E., Srzednicki, M. & Sadowski, Z. (1996) Effect of testosterone replacement therapy on lipids and lipoproteins in hypogonadal and elderly men. Atherosclerosis 121, 35-43.
49. Zmuda, J. M., Fahrenback, M. C., Younkin, B. T., Bausserman, L. L., Terry, R. B., Catlin, D. H. & Thompson, P. D. (1993) The effect of testosterone aromatization on high-density lipoprotein cholesterol level and postheparin lipolytic activity. Metabolism 42, 446-450.