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The structure of the stable trimeric domain of Ii (invariant chain protein), as revealed by NMR spectroscopy. This skillful structure determination provides significant insight into the mode of function of Ii.
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Structure of human histocompatibility leukocyte antigen (HLA)-Cw4, a ligand for the KIR2D natural killer cell inhibitory receptor
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The structure of a C allele human MHC class I molecule is added to the database. A full sample of these human allele structures is essential to our understanding of peptide-binding motifs.
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Crystal structure of HLA-DR2 (DRA*0101, DRB1*1501) complexed with a peptide from human myelin basic protein
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This report extends the structural database of MHC class II alleles to include a complex of particular importance in autoimmune disease.
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Smith K.J., Pyrdol J., Gauthier L., Wiley D.C., Wucherpfennig K.W. Crystal structure of HLA-DR2 (DRA*0101, DRB1*1501) complexed with a peptide from human myelin basic protein. J Exp Med. 188:1998;1511-1520. This report extends the structural database of MHC class II alleles to include a complex of particular importance in autoimmune disease.
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d-peptide complexes reveal that high affinity can be achieved without large anchor residues
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b/glycopeptide complexes suggest a molecular basis for CTL cross-reactivity
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A lovely insight into the similarities and differences in how two T-cell receptors recognise the same MHC class I-peptide ligand.
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Four A6 TCR/peptide/HLA-A2 structures that generate very different T cell signals are nearly identical
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This report beautifully highlights the subtlety of the structural differences that are sufficient to change grossly the functional outcome of T-cell receptor binding.
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•], reports the crystal structure of a second member of the KIR family. Unexpectedly, the interdomain orientation of the KIR molecules is shown to be variable.
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The first structural information on the C-lectin-type family of natural killer cell receptors, the cognate receptors for the nonclassical MHC class Ib molecule HLA-E.
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