Nitric oxide is involved in the lesions of the peripheral autonomic neurons observed in the acute phase of experimental Trypanosoma cruzi infection

Experimental Parasitology

Volumn 93, Issue 4, 1999, Pages 191-197

  Garcia, Sérgio B ^a,b   Paula, Jayter S ^a   Giovannetti, Gustavo S ^a   Zenha, Fabio ^a   Ramalho, Erika M ^a   Zucoloto, Sérgio ^a   Silva, João S ^a   Cunha, Fernando Q ^a  

^a UNIVERSITY OF SÃO PAULO   (Brazil)

^b IMPERIAL CANCER RESEARCH FUND   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

N(G) NITROARGININE; NITRATE; NITRIC OXIDE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE DEHYDROGENASE;

ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CHAGAS DISEASE; CONTROLLED STUDY; ENZYME ACTIVITY; HISTOCHEMISTRY; MALE; MOUSE; NERVE CELL; NONHUMAN; PERIPHERAL NERVOUS SYSTEM; PRIORITY JOURNAL; TRYPANOSOMA CRUZI; TRYPANOSOMIASIS;

ANIMALIA; MURINAE; PROTOZOA; TRYPANOSOMA; TRYPANOSOMA CRUZI;

EID: 0032761055     PISSN: 00144894     EISSN: None     Source Type: Journal    
DOI: 10.1006/expr.1999.4451     Document Type: Article

References (33)

1. Adams, L. B., Hibbs, J. B., Taintor, R. R., and Kraheenbuhl, J. L. 1990. Microbiostatic effect of murine-activated macrophages for Toxoplasma gondii: role for synthesis of inorganic nitrogen from L-arginine. J Immunol 144, 2725-2729.
2. Alcântara, F. G., Oliveira, J. A., and Oliveira, J. S. M. 1965. Parassimpático do tracto digestivo no camundongo com infeccão chagásica aguda experimental. O Hospital 68, 223-233.
3. Andrade, S. G., and Andrade, Z. A. 1966. Doença de Chagas e alterações neuronais no plexo de Auerbach. RevInstMedTrop de São Paulo 8, 219-224.
4. Bocca, A. L., Hayashi, E. E., Pinheiro, A. G., Furlanetto, A. B., Campanelli, A. P., Cunha, F. Q., and Figueiredo, F. 1998. Treatment of Paracoccidioides brasiliensis-infected mice with a nitric oxide inhibitor prevents the failure of cell-mediated immune response. J Immunology 161, 3056-3063.
5. Chagas, C. 1916. Pathogenic process of American Trypanosomiasis. Mem Inst Oswaldo Cruz 8, 3-36.
6. Chao, C. C., Hu, S, Molitor, T. W., Shaskan, E. G., and Peterson, P. K. 1992. Activated microglia mediate neuronal cell injury via nitric oxide mechanism. J Immunol 149, 2736-2741.
7. Evans, T. G., Reed, S. S., and Hibbs, J. R. 1996. Nitric oxide production in murine leishmaniasis: correlation of progressive infection with increase in systemic synthesis of nitric oxide. Am J Trop Med Hyg 54, 486-489.
8. Farrel, A. J., Blake, D. R., Palmer, M. J., and Moncada, S. 1992. Increased concentrations of nitrite in synovial fluid and serum samples suggest increased nitric oxide synthesis in rheumatic diseases. Ann Rheum Dis 51, 1219-1222.
9. Flesch, I. E. A., and Kaufmann, S. H. E. 1991. Mechanisms involved in mycobacterial growth inhibition by gamma interferon-activated bone marrow macrophages: role of reactive nitrogen intermediates. Infec Immun 59, 3213-3218.
10. Gazzinelli, R. T., Oswald, I. P., Hienry, S., James, S. L., and Sher, A. 1992. The microbicidal activity of Interferon-γ-treated macrophages against T.cruzi involves and L-arginine-dependent, nitrogen oxide mediated mechanism inhibitable by IL-10 and transforming growth factor-β. Eur J Immunol 22, 2501-2507.
11. Hope, B. T., Michael, G. J., Knigge, K. M., and Vicent, S. R. 1991. Neuronal NADPH diaphorase is a nitric oxide synthase. Proc Natl Acad Sci 88, 2811-2814.
12. Hope, B. T., and Vincent, S. R. 1989. Histochemical characterization of neuronal NADPH diaphorase. J Histochem Cytochem 37, 653-661.
13. Iyengar, R., Stuehr, D. J., and Marletta, M. A. 1987. Macrophage synthesis of nitrite, nitrate and N-nitrosamines: precursors and role of the respiratory burst. Proc Natl Acad Sci 84, 6369-6373.
14. Khoury, E. L., Ritacco, V., Cossio, P. N., Languens, R. P., Szarfman, A, Diez, C, and Arana, R. M. 1979. Circulating antibodies to peripheral nerve in american trypanosomiasis. Clin Exp Immunol 36, 8-12.
15. Koberle, F. 1963. Enteromegaly and cardiomegaly in Chagas disease. Gut 4, 399-405.
16. Koberle, F. 1968. Chagas' disease and Chagas' Syndromes: The pathology of american trypanosomiasis: Adv Parasitol 6, 63-116.
17. Miller, M. J. S., Sadowska-Krowicka, H., Chotinaruemol, S., Kakkis, J. L., and Clark, D. A. 1993. Amelioration of chronic ileitis by nitric oxide synthase inhibition. J Pharmacol Exp Ther 264, 11-16.
18. Moncada, S., Palmer, R. M. J., and Higgs, E. A. 1991. Nitric oxide: physiology, pathophysiology and pharmacology of nitric oxide. Pharmac Rev 43, 109-242.
19. Oliveira, J. S. M. 1985. A natural human model of intrisic heart nervous system denervation: Chagas' cardiopathy. Am Heart J 110, 1092-1098.
20. Oliveira, J. S. M., Llorach-Veludo, M, A. S, and Sales-Nero, V. N. 1990. Megacolon in rats. Digestion 25, 166-171.
21. Perez-Fuentes, R., Sanchez-Guillen, M. C., Gonzalez-Alvarez, C., Monteon, V. M., Reyes, P. A., and Rosales-Encina J. L. 1998. Humoral nitric oxide levels and antibody immune response of symptomatic and indeterminate Chagas'disease patients to commercial and autochthonous Trypanosoma cruzi antigen. Am J Trop Med Hyg 58, 715-720.
22. Ribeiro dos Santos, R., and Hudson, L. 1980. Trypanosoma cruzi: immunological consequences of parasite modification of host cells. Clin Exp Immunol 40, 36-41.
23. Rockett, K. A., Auburu, M. M., Rockett, E. J., Coride, W. B., and Clark, I. 1994. A possible role of nitric oxide in malarial immunosuppression. Paras Immunol 16, 243.
24. Rossi, M. A., and Bestetti, R. B. 1995. The challenge of chagasic cardiomyopathy. The pathologic roles of autonomie abnormalities, autoimmune mechanisms and microvascular changes, and therapeutic implications. Cardiology 86, 1-7.
25. Rottemberg, M. E., and Orn, A. 1997. Conflicting roles of NO in Trypanosoma cruzi infection. The Immunologist 5/4, 127-131.
26. Schmidt, H. H. W., Wilke, W., Evers, B., and Bohme, E. 1989. Enzymatic formation of nitrogen oxides from L-arginine in bovine brain cytosol. Biochem Biophys Res Commun 165, 284-291.
27. Souza-Filho, M. V. P., Lima, M. V. A., Pompeu, M. M. L., Ballejo, G., Cunha, F. Q., and Ribeiro, R. A. 1997. Involvement of nitric oxide in the Pathogenesis of cyclophosphamide-induced hemorrhagic cystitis. Am J Pathol 150, 247-256.
28. Stemberg, J., and McGuigan, F. 1992. Nitric oxide mediates suppression of T cell response in murine Trypanosoma brucei infection. Eur J Immunol 22, 2741-2745.
29. Tavares-Murta, B. M., Cunha, F. Q., and Ferreira, S. H. 1998. The intravenous administration of tumor necrosis factor-alpha, interleukin-8 and macrophage-derived neutrophil chemotactic factor inhibits neutrophil migration by stimulating nitric oxide production. Br J Pharmacol 124, 1369-1374.
30. Vespa, G. N., Cunha, F. Q., and Silva, J. S. 1994. Nitric oxide is involved in control of Trypanosoma cruzi-induced parasitaemia and directly kills the parasite in vitro. Infection and Immunity 62, 5177-5182.
31. Vianna G. 1911. Contribuição para o estudo da anatomia patológica da "Moléstia de Carlos Chagas". Mem Inst Oswaldo Cruz 3, 276-293.
32. Vichi, F. L. 1964. Avaliação quantitativa do parasitismo no coração, vasos da base e coronária do rato, na fase aguda da moléstia de Chagas. Rev Inst Med Trop São Paulo 6, 292-296.
33. Wright, C. E., Rees, D. D., and Moncada, S. 1992. Protective and pathological roles of nitric oxide in endotoxin shock. Cardiovasc Res 26, 48-57.