Apoptosis and 8-hydroxydeoxyguanosine levels in renal tissue after an injection of ferric nitrilotriacetate, a renal carcinogen, in male Wistar rats maintained on vitamin E-deficient, -normal or -supplemented diets

Pathophysiology

Volumn 6, Issue 3, 1999, Pages 149-156

  Eguchi, Kaori ^a   Akiyama, Takashi ^a   Kiriu, Takahiro ^a   Minamiyama, Yukiko ^b   Okada, Shigeru ^a  

^a OKAYAMA UNIVERSITY MEDICAL SCHOOL   (Japan)

^b Osaka Prefecture University   (Japan)

Author keywords

8 Hydroxydeoxyguanosine (8 OHdG); Apoptosis; Iron nitrilotriacetate (Fe NTA); Vitamin E deficient

Indexed keywords

8 HYDROXYDEOXYGUANOSINE; ALPHA TOCOPHEROL; NITRILOTRIACETATE IRON;

ALPHA TOCOPHEROL DEFICIENCY; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BODY WEIGHT; CONTROLLED STUDY; DIET SUPPLEMENTATION; DNA MODIFICATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; IMMUNOHISTOCHEMISTRY; KIDNEY PARENCHYMA; MALE; NONHUMAN; PEROXIDATION; PRIORITY JOURNAL; RAT;

EID: 0032760702     PISSN: 09284680     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0928-4680(99)00006-1     Document Type: Article

References (37)

1. Okada S. Iron-induced tissue damage and cancer: the role of reactive oxygen species-free radicals. Pathol. Int. 46:1996;311-332.
2. Groot H. Reactive oxygen species in tissue injury. Hepatogastroenterology. 41:1994;328-332.
3. Fukuzawa K., Fujii T., Ikebata W. Lipid peroxidation by iron chelated with nitrilotriacetate: (1) Induction dependent on hydrogen peroxide and lipid hydroperoxide. Yagi K., Kondo M., Niki E., Yoshikawa T. Oxygen Radicals. 1992;237-240 Elsevier Science Publishers, Amsterdam.
4. Fukuzawa K., Fujii T., Mukai K. Lipid peroxidation by iron chelated with nitrilotriacetate: (2) Induction without the requirement for hydrogen peroxide and lipid hydroperoxides. Yagi K., Kondo M., Niki E., Yoshikawa T. Oxygen Radicals. 1992;241-245 Elsevier Science Publishers, Amsterdam.
5. Hamazaki S., Okada S., Li J.L., Toyokuni S., Midorikawa O. Oxygen reduction and lipid peroxidation by iron chelates with special reference to ferric nitrilotriacetate. Arch. Biochem. Biophys. 272:1989;10-17.
6. Okada S., Hamazaki S., Zhang D., Ma Y. Iron-induced, free radical-mediated renal carcinogenesis in rats and mice: modification by sex and vitamin E. Packer L., Ong A.S.H. Biological Oxidants: Mechanism and Health Effects. 1998;358-361 AOCS Press, Champaign, IL.
7. Umemura T., Sai K., Takagi A., Hasegawa R., Kurokawa Y. Formation of 8-hydroxydeoxyguanosine (8-OH-dG) in rat kidney DNA after intraperitoneal administration of ferric nitrilotriacetate (Fe-NTA). Carcinogenesis. 11(2):1990;345-347.
8. Toyokuni S., Tanaka T., Hattori Y., Nishiyama Y., Yoshida A., Uchida K., Hiai H., Ochi H., Osawa T. Quantitative immunohistochemical determination of 8-hydroxy-2′-deoxyguanosine by a monoclonal antibody N45.1: its application to ferric nitrilotriacetate-induced renal cacinogenesis model. Lab. Invest. 76(3):1997;365-374.
9. Shigenaga M.K., Gimeno C.J., Ames B.N. Urinary 8-hydroxy-2′-deoxyguanosine as a biological marker of in vivo oxidative DNA damage. Proc. Natl. Acad. Sci. USA. 86:1989;9697-9701.
10. Umemura T., Hasegawa R., Sai-Kato K., Nishikawa A., Furukawa F., Toyokuni S., Uchida K., Inoue T., Kurosawa Y. Prevention by 2-mercaptoethane sulfonate and N-acetylcysteine of renal oxidative damage in rats treated with ferric nitrilotriacetate. Jpn. J. Cancer Res. 88:1997;18-25.
11. Kawabata T., Ma Y., Yamadori I., Okada S. Iron-induced apoptosis in mouse renal proximal tubules after an injection of a renal carcinogen, iron-nitrilotriacetate. Carcinogenesis. 18(7):1997;1389-1394.
12. Okada S., Midorikawa O. Induction of the rat renal adenocarcinoma by Fe-nitrilotriacetate (Fe-NTA). Jpn. Arch. Intern. Med. 29:1982;485-491.
13. Ebina Y., Okada S., Hamazaki S., Ogino F., Li J.L., Midorikawa O. Nephrotoxicity and renal cell carcinoma after use of iron- and aluminium-nitrilotriacetate complex in rats. J. Natl. Cancer Inst. 76:1986;107-113.
14. Li J.L., Okada S., Hamazaki S., Ebina Y., Midorikawa O. Subacute nephrotoxicity and induction of renal cell carcinoma in mice treated with ferric nitrilotriacetate. Cancer Res. 47:1987;1867-1869.
15. Kasai H., Nishimura S. Formation of 8-hydroxydeoxyguanosine in DNA by oxygen radicals and its biological significance. Sies H. Oxidative Stress: Oxidants and Antioxidants. 1991;99-106 Academic Press, London.
16. Kasai H., Nishimura S. Hydroxylation of deoxyguanosine at the C-8 position by ascorbic and other reducing agents. Nucleic Acids Res. 12:1984;2137-2145.
17. Park J.W., Floyd R.A. Lipid peroxidation products mediated the formation of 8-hydroxydeoxyguanosine in DNA. Free Radic. Biol. Med. 12:1992;245-250.
18. Zhang D., Okada S., Yu Y., Zheng P., Yamaguchi R., Kasai H. Vitamin E inhibits apoptosis, DNA modification, and cancer incidence induced by iron-mediated peroxidation in Wistar rat kidney. Cancer Res. 57:1997;2410-2414.
19. Hamazaki S., Okada S., Ebina Y., Li J.L., Midorikawa O. Effect of dietary vitamin E on ferric nitrilotriacetate-induced nephrotoxicity in rats. Toxicol. Appl. Pharmacol. 92:1988;500-506.
20. Okada S., Kiriu T., Zhang D. Protective role of vitamin E on iron-induced nephrotoxicity and carcinogenesis: a model of free radical pathology. Ohigashi H., Osawa T., Terao J., Watanabe S., Yoshikawa T. Food Factors for Cancer Prevention. 1997;444-447 Springer-Verlag, Tokyo.
21. B. Halliwell, I. Aruoma, DNA damage by oxygen-derived species: its mechanism and measurement in mammalian systems, FEBS Lett. 281 (1991) 9-19.
22. Niki E. Action of vitamin E as an antioxidant. Vitamins. 62(11):1988;601-619. (in Japanese).
23. Okada S., Hamazaki S., Ebina Y., Li J.L., Midorikawa O. Nephrotoxicity and its prevention by vitamin E in ferric nitorilotriacetate-promoted lipid peroxidation. Biochim. Biophys. Acta. 922:1987;28-33.
24. Osawa T., Yoshida A., Kawakishi S., Yamashita K., Ochi H. Protective role of dietary antioxidants in oxidative stress. Cutler R.G., Packer L., Bertram J., Mori A. Oxidative Stress and Aging. 1995;367-377 Birkhauser Verlag, Switzerland.
25. Awai M., Narasaki M., Yamanoi Y., Seno S. Induction of diabetes in animals by parenteral administration of ferric nitriloacetate. Am. J. Pathol. 95:1979;663-674.
26. Cannan R.K. Proposal for adoption of an international method and standard solution for hemoglobinometry, specifications for preparation of the standard solution, and notification of availability of a reference standard solution. Am. J. Clin. Pathol. 44(2):1965;207-209.
27. Gavrieli Y., Sherman Y., Ben-Sasson S.A. Identification of programmed death in situ via specific labeling of nuclear DNA fragmentation. J. Cell Biol. 119(3):1992;493-501.
28. Nakase D., Mizumoto Y., Kobayashi E., Noguchi O., Konishi Y. Improved genomic/nuclear DNA extraction for 8-hydroxydeoxyguanosine analysis of small amounts of rat liver tissue. Cancer Lett. 97:1995;233-239.
29. Floyd R.A., Watson J.J., Wong P.K., Altmiller D.H., Rickard R.C. Hydroxyl free radical adduct of deoxyguanosine: sensitive detection and mechanisms of formation. Free Radic. Commun. 1:1986;163-172.
30. Kasai H., Crain P.F., Kuchino Y., Nishimura S., Ootsuyama A., Tanooka H. Formation of 8-hydroxyguanine moiety in cellular DNA by agents producing oxygen radicals and evidence for its repair. Carcinogenesis. 7:1986;1849-1851.
31. Miki M., Tamai H., Mino M., Yamamoto Y., Niki E. Free-radical chain oxidation of rat red blood cells by molecular oxygen and its inhibition by α-tocopherol. Arch. Biochem. Biophys. 258(2):1987;373-380.
32. Yamamoto Y., Niki E., Kamiya Y., Miki M., Tamai H. Free radical chain reaction and hemolysis of erythrocytes by molecular oxygen and their inhibition by vitamin E. J. Nutr. Sci. Vitaminol. 32:1986;475-479.
33. Bei R.A., Brandt R.B., Rosenblum W.I., Nelson G.H., Chan W. Murine red blood cell fragility is not affected by either vitamin E depletion or supplementation. Proc. Soc. Exp. Biol. Med. 212:1996;280-283.
34. Burton G.W., Joyce A., Ingold K.U. Is vitamin E the only lipid-soluble, chain-breaking antioxidant in human blood plasma and erythrocyte membranes? Arch. Biochem. Biophys. 221(1):1983;281-290.
35. Yamamoto Y., Niki E., Eguchi J., Kamiya Y., Shimasaki H. Oxidation of biological membranes and its inhibition. Free radical chain oxidation of erythrocyte ghost membrane by oxygen. Biochim. Biophys. Acta. 819:1985;29-36.
36. Wyllie A.H., Keer J.F.R., Currie A.R. Cell death: the significance of apoptosis. Int. Rev. Cytol. 68:1980;251-306.
37. Yamamoto K., Niki E. Interaction of α-tocopherol with iron: antioxidant and prooxidant effects of α-tocopherol in the oxidation of lipids in aqueous dispersions in the presence of iron. Biochim. Biophys. Acta. 958:1988;19-23.