Differentiation of coronary smooth muscle cells to a cell cycle-arrested hypertrophic growth status by a synthetic non-toxic heparin-mimicking compound

Atherosclerosis

Volumn 147, Issue 2, 1999, Pages 387-397

  Schmidt, A ^a   Vlodavsky, I ^b   Volker W ^a   Buddecke, E ^a  

^a UNIVERSITY OF MÜNSTER   (Germany)

^b HADASSAH HEBREW UNIVERSITY MEDICAL CENTER   (Israel)

Author keywords

Cell cycle; Cell proliferation; Heparin mimicking compound; MAP kinase; Protein kinase C; Smooth muscle cell hypertrophy

Indexed keywords

BASIC FIBROBLAST GROWTH FACTOR; HEPARAN; MITOGEN ACTIVATED PROTEIN KINASE; POLY 4 HYDROXYPHENOXY ACETIC ACID; PROTEIN KINASE C; PROTEOHEPARAN SULFATE; RG 13 577; UNCLASSIFIED DRUG;

ANIMAL CELL; APOPTOSIS; ARTICLE; CATTLE; CELL CYCLE; CELL DIFFERENTIATION; CELL DIVISION; CELL GROWTH; CORONARY ARTERY; ENZYME LINKED IMMUNOSORBENT ASSAY; HYPERTROPHY; NONHUMAN; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; VASCULAR SMOOTH MUSCLE;

ANIMALS; AORTA, THORACIC; CATTLE; CELL CYCLE; CELL DIVISION; CORONARY VESSELS; CULTURE TECHNIQUES; ENZYME-LINKED IMMUNOSORBENT ASSAY; FIBROBLAST GROWTH FACTORS; MUSCLE, SMOOTH, VASCULAR; PHENOXYACETATES; POLYMERS; REFERENCE VALUES; SENSITIVITY AND SPECIFICITY;

EID: 0032759284     PISSN: 00219150     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0021-9150(99)00209-9     Document Type: Article

References (46)

1. Burgess W.H., Maciag T. The heparin-binding (fibroblast) growth factor family of proteins. Ann. Rev. Biochem. 58:1989;575-606.
2. Fuster V., Badimon J.J., Chesebro J.H. The pathogenesis of coronary artery disease and the acute coronary syndromes. N. Engl. J. Med. 326:1992;242-245.
3. Ross R. The pathogenesis of arteriosclerosis: a perspective for the 1990s. Nature. 362:1993;801-809.
4. Schmidt A., Skaletz-Rorowski A., Breithardt G., Buddecke E. Growth status-dependent changes of bFGF compartmentalization and heparan sulfate structure in arterial smooth muscle cells. Eur. J. Cell Biol. 67:1995;130-135.
5. Schmidt A., Buddecke E. Cell-associated proteoheparan sulfate from bovine arterial smooth muscle cells. Exp. Cell Res. 178:1988;242-253.
6. Sakata N., Kawamura K., Takebayashi S. Effects of collagen matrix on proliferation and differentiation of vascular smooth muscle cells in vitro. Exp. Mol. Pathol. 52:1990;179-191.
7. Nobuyoshi M., Kimura T., Ohishi H., Horiuchi H., Nosaka H., Hamasaki N., Yokoi H., Kim K. Restenosis after percutaneous transluminal coronary angioplasty: pathologic observations in 20 patients. J. Am. Coll. Cardiol. 17:1991;433-439.
8. Riessen R., Isner J.M., Blessing E., Loushin C., Nikol S., Wight T.N. Regional differences in the distribution of the proteoglycans biglycan and decorin in the extracellular matrix of atherosclerotic and restenotic human coronary arteries. Am. J. Pathol. 144:1994;962-974.
9. Mac Leod D.C., Strauss B.H., de Jong M., Escaned J., Umans V.A., van Suylen R.J., Verkerk A., de Feyter P.J., Serruys P.W. Proliferation and extracellular matrix synthesis of smooth muscle cells cultured from human coronary atherosclerotic and restenotic lesions. J. Am. Coll. Cardiol. 23:1994;59-65.
10. Yayon A., Klagsbrun M., Esko J.D., Leder P., Ornitz D.M. Cell surface heparin-like molecules are required for binding of basic fibroblast growth factor to its high affinity receptor. Cell. 64:1991;841-848.
11. Ornitz D.M., Yayon A., Flanagan J.G., Svahn C.M., Levi E., Leder P. Heparin is required for cell-free binding of bFGF to a soluble receptor and for mitogenesis in whole cells. Mol. Cell Biol. 12:1992;240-247.
12. Rapraeger A., Krufka A., Olwin B.R. Requirement of heparan sulfate for bFGF-induced fibroblast growth and myoblast differentiation. Science. 252:1991;1705-1708.
13. Turnbull J.E., Femig D.G., Ke Y., Wilkinson M., Gallagher J.T. Identification of basic fibroblast growth factor binding sequence in fibroblast heparan sulfate. J. Biol. Chem. 267:1992;10337-10341.
14. Aviezer D., Levy E., Safran M., Svahn C., Buddecke E., Schmidt A., David G., Vlodavsky I., Yayon A. Differential structural requirements of heparin and heparan sulfate proteoglycans that promote binding of basic fibroblast growth factor to its receptor. J. Biol. Chem. 269:1994;114-121.
15. Ishihara M., Tyrell D.J., Stauber G.B., Brown S., Cousens L., Stack R.J. Preparation of affinity-fractionated heparin-derived oligosaccharides and their effects on selected biological activities mediated by basic fibroblast growth factor. J. Biol. Chem. 268:1993;4675-4683.
16. Guimond S., Maccarana M., Olwin B.B., Lindahl U., Rapraeger A.C. Activating and inhibiting sequences for FGF-2 (basic FGF). J. Biol. Chem. 268:1993;23906-23914.
17. Spivak-Krouzman T., Lemmon M.A., Dikic I., Ladbury J.E., Pinchasi D., Huang J., Jaye M., Cru mley G., Schlessinger J., Lax I. Heparin-induced oligomerization, activation and cell proliferation. Cell. 79:1994;1015-1024.
18. Benezra M., Ben-Sasson S.A., Regan J., Chang M., Bar-Shavit R., Vlodavsky I. Antiproliferative activity towards vascular smooth muscle cells and receptor binding of heparin-mimicking anionic aromatic compounds. Arterioscler. Throm. 14:1994;1989-1992.
19. Benezra M., Vlodavsky I., Yayon A., Bar-Shavit R., Ben-Sasson S. Reversal of bFGF-mediated autocrine cell transformation by aromatic anionic compounds. Cancer Res. 52:1992;5656-5662.
20. Regan J.R., Ben-Sasson S.A., Sabatino R., Eilat D., Bruno J.G., D'Alisa R., Chang M.N. Mimicry of biological macromolecules by polyaromatic anionic compounds. J. Bioact. Comp. Polym. 8:1993;317-337.
21. Miao H.Q., Ornitz D.M., Aingorn E., Ben-Sasson S.A., Vlodavsky I. Modulation of fibroblast growth factor-2 receptor binding, dimerization, signaling and angiogenetic activity by a synthetic heparin-mimicking compound. J. Clin. Invest. 99:1997;1565-1575.
22. Skaletz-Rorowski A., Schmidt A., Breithardt G., Buddecke E. Heparin-induced overexpression of basic fibroblast growth factor, basic fibroblast growth factor receptor and cell-associated proteoheparan sulfate in cultured coronary smooth muscle cells. Arterioscler. Thromb. Vasc. Biol. 16:1996;1063-1069.
23. Oegema T.R., Hascall V.C., Dziewiatkowski D.D. Isolation and characterization of proteoglycans from the swarm rat chondrosarcoma. J. Biol. Chem. 250:1975;6151-6159.
24. Tata JR. Isolation of nuclei from liver and other tissues, Methods Enzymol 1974;31:253-262.
25. Seligman A.M., Wasserkrug H.L., Hanker J.S. A new staining method (OTO) for enhancing in osmium tetroxide-fixed tissue with osmiophilic thiocarbohydrazide (TCH). J. Cell Biol. 30:1966;424-432.
26. Robinson M.J., Cobb M.H. Mitogen activated protein kinase pathways. Curr. Opin. Cell Biol. 9:1997;180-186.
27. Cobb M.H., Goldsmith E.J. How MAP kinases are regulated. J. Biol. Chem. 270:1995;14843-14846.
28. Tsutakawa S.E., Medzihradszky K.F., Flint A.J., Burlingame A.L., Koshland D.E. Jr. Determination of in vivo phosphorylation sites in protein kinase C. J. Biol. Chem. 270:1995;26807-26812.
29. Keranen L.M., Dutil E.M., Newton A.C. Protein kinase C is regulated in vivo by three functionally distinct phosphorylations. Curr. Biol. 5:1995;1394-1403.
30. Schmidt A., Yoshida K., Buddecke E. The antiproliferative activity of arterial heparan sulfate resides in domains enriched with 2-O-sulfated uronic acid residues. J. Biol. Chem. 267:1992;19242-19247.
31. Clowes A.W., Karnovsky M.J. Suppression by heparin of smooth muscle cell proliferation in injured arteries. Nature. 265:1977;625-626.
32. Castellot J.J., Pukac L.A., Caleb B.L., Wright T.C., Karnovsky M.J. Heparin selectively inhibits a protein kinase C-dependent mechanism of cell cycle progression in calf aortic smooth muscle cells. J. Cell. Biol. 109:1989;3147-3155.
33. Kolch W., Heldecker G., Kochs G., Hummel R., Vahidi H., Mischak H., Finkenzeller G., Marm E., Rapp U.R. Protein kinase C-α activates RAF-1 by direct phosphorylation. Nature. 364:1993;249-252.
34. Watanabe T., Ono Y., Taniyama Y., Hazama K., Igarashi K., Ogita K., Kikkawa U., Nishizuka Y. Cell division arrest induced by phorbol ester in CHO cells overexpressing protein kinase C-α subspecies. Proc. Natl. Acad. Sci. USA. 89:1992;10159-10163.
35. Mischak H., Goodnight J., Kolch W., Martiny-Baron G., Schaechtle C., Kazanietz M.G., Blumberg P.M., Pierce J.H., Mushinsk J.F. Overexpression of protein kinase C-α and γ in NIH 3T3 cells induces opposite effects on growth, morphology, anchorage dependence and tumorigenicity. J. Biol. Chem. 268:1993;6090-6096.
36. Goldstein D.R., Cacae A.M., Weinstein I.B. Overexpression of protein kinase C in the SW480 colon cancer cell line causes growth suppression. Carcinogenesis. 16:1995;1121-1126.
37. Kim S., Ohta K., Hamaguchi A., Miura, Yukimura T., Iwao H. Suppression of vascular transforming growth factor-beta and extracellular matrix gene expressions by cilazapril and nifedipine in hypertensive rats. Clin. Exp. Pharmacol. Physiol. Suppl. 1:1995;S355-356.
38. Ben-Driss A., Benessiano J., Poitevin P., Levy B.I., Michel J.B. Arterial expansive remodeling induced by high flow rates. Am. J. Physiol. 272:1997;851-858.
39. Pratt R.E. Regulation of vascular smooth-muscle cell growth by angiotensin II. Blood Press. (Suppl.). 2:1996;6-9.
40. Rosendorff C. Endothelin, vascular hypertrophy and hypertension. Cardiovasc. Drugs Ther. 10:1997;795-802.
41. Lee S.L., Wang W.W., Joseph P.M., Fanburg B.L. Inhibitory effect of heparin on serotonin-induced hyperplasia and hypertrophy of smooth muscle cells. Am. J. Respir. Cell Mol. Biol. 17:1997;78-83.
42. Virone-Oddos A., Desangle V., Provost D., Cazes M., Caussade F., Cloarec A. In vitro and in vivo effects of UP 269-6 a new potent orally active non peptide angiotensin II receptor antagonist on vascular smooth muscle cell proliferation. Br. J. Pharmacol. 120:1997;488-494.
43. Vinter-Jensen L., Juhl C.O., Dajani E.Z., Nielsen K., Djurhuus J.C. Chronic systemic treatment with epidermal growth factor induces smooth muscle cell hyperplasia and hypertrophy in the urinary tract of mature Goettingen mini pigs. Br. J. Urol. 79:1997;532-538.
44. Amann K., Wolf B., Nichols C., Torning J., Schwarz U., Zeier M., Mall G., Ritz E. Aortic changes in experimental renal failure: hyperplasia or hypertrophy of smooth muscle cells? Hypertension. 29:1997;770-775.
45. Amann K., Gharehbaghi H., Stephen S., Mall G. Hypertrophy and hyperplasia of smooth muscle cells of small intramyocardial arteries in spontaneously hypertensive rats. Hypertension. 25:1995;124-131.
46. Lindner V., Lappi D.A., Baird A., Majack R.A., Reidy M.A. Role of basic fibroblast growth factor in vascular lesion formation. Circ. Res. 68:1991;106-113.