Prophylactic fluconazole in liver transplant recipients: A randomized, double-blind, placebo-controlled trial

Annals of Internal Medicine

Volumn 131, Issue 10, 1999, Pages 729-737

  Winston, Drew J ^a,b   Pakrasi, Anita ^a,b   Busuttil, Ronald W ^a,b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UCLA MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

FLUCONAZOLE;

ADULT; AGED; ARTICLE; CANDIDA; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; DRUG EFFICACY; DRUG RESPONSE; DRUG SAFETY; FEMALE; GASTROINTESTINAL SYMPTOM; HEADACHE; HUMAN; INFECTION PREVENTION; INTRAVENOUS DRUG ADMINISTRATION; LIVER TRANSPLANTATION; MAJOR CLINICAL STUDY; MALE; MORTALITY; MYCOSIS; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; PROPHYLAXIS; RANDOMIZED CONTROLLED TRIAL; SEIZURE; SURVIVAL RATE;

EID: 0032758271     PISSN: 00034819     EISSN: None     Source Type: Journal    
DOI: 10.7326/0003-4819-131-10-199911160-00003     Document Type: Article

References (30)

1. Paya CV. Fungal infections in solid-organ transplantation. Clin Infect Dis. 1993;16:677-88.
2. Goodman JL, Winston DJ, Greenfield RA, Chandrasekar PH, Fox B, Kaizer H, et al. A controlled trial of fluconazole to prevent fungal infections in patients undergoing bone marrow transplantation. N Engl J Med. 1992; 326:845-51.
3. Slavin MA, Osborne B, Adams R, Levenstein MJ, Schoch HG, Feldman AR, et al. Efficacy and safety of fluconazole prophylaxis for fungal infections after marrow transplantation - a prospective, randomized, double-blind study. J Infect Dis. 1995;171:1545-52.
4. Winston DJ, Emmanouilides C, Busuttil RW. Infections in liver transplant recipients. Clin Infect Dis. 1995;21:1077-91.
5. Busuttil RW, Shaked A, Millis JM, Jurim O. Colquhoun SD, Shackleton CR, et al. One thousand liver transplants. The lessons learned. Ann Surg. 1994;219:490-9.
6. Emmanouilides C, Holt CD, Winston DJ. Infections after liver transplantation. In: Busuttil RW, Klintmalm GB, eds. Transplantation of the Liver. Philadelphia: WB Saunders; 1996:633-47.
7. Winston DJ, Wirin D, Shaked A, Busuttil RW. Randomised comparison of ganciclovir and high-dose acyclovir for long-term cytomegalovirus prophylaxis in liver-transplant recipients. Lancet 1995;346:69-74.
8. 3H RIA. Am J Clin Pathol. 1987;87:528-32.
9. Kaplan EL, Meier P. Nonparametric estimation from incomplete observations. Journal of the American Statistical Association. 1958;53:457-81.
10. Lee ET. Statistical Methods for Survival Data Analysis. Belmont, CA: Lifetime Learning Publications; 1980.
11. Cox DR. Regression models and life-tables. Journal of the Royal Statistical Society Series B. 1972;34:187-220.
12. Wajszczuk CP, Dummer JS, Ho M, Van Thiel DH, Starzl TE, Iwatsuki S, et al. Fungal infections in liver transplant recipients. Transplantation. 1985; 40:347-53.
13. Castaldo P, Stratta RJ, Wood RP, Markin RS, Patil KD, Shaefer MS, et al. Clinical spectrum of fungal infections after orthotopic liver transplantation. Arch Surg. 1991;126:149-56.
14. Collins LA, Samore MH, Roberts MS, Luzzati R, Jenkins RL, Lewis WD, et al. Risk factors for invasive fungal infections complicating orthotopic liver transplantation. J Infect Dis. 1994;170:644-52.
15. Patel R, Portela D, Badley AD, Harmsen WS, Larson-Keller JJ, Ilstrup DM, et al. Risk factors of invasive Candida and non-Candida fungal infections after liver transplantation. Transplantation. 1996;62:926-34.
16. Ruskin JD, Wood RP, Bailey MR, Whitmore CK, Shaw BW. Comparative trial of oral clotrimazole and nystatin for oropharyngeal candidiasis prophylaxis in orthotopic liver transplant patients. Oral Surg Oral Med Oral Pathol. 1992;74:567-71.
17. Tortorano AM, Viviani MA, Pagano A, Paone G, Oridelli B. Breda G, et al. Candida colonization in orthotopic liver transplantation: fluconazole versus oral amphotericin B. British Journal of Mycology and Medicine. 1995;5:21-4.
18. Mora NP, Klintmalm G. Solomon H, Goldstein RM, Gonwa TA, Husberg BS. Selective amphotericin B prophylaxis in the reduction of fungal infections after liner transplant. Transplant Proc. 1992;24:154-5.
19. Singh N, Mieles L, Yu VL, Gayowski T. Invasive aspergillosis in liver transplant recipients: association with candidemia and consumption coagulopathy and failure of prophylaxis with low-dose amphotericin B. Clin Infect Dis. 1993;17:906-8.
20. Tollemar J, Höckerstedt K, Ericzon BG, Jalanko H, Ringden O. Liposomal amphotericin B prevents invasive fungal infections in liver transplant recipients. A randomized, placebo-controlled study. Transplantation. 1995;59:45-50.
21. Lumbreras C, Cuervas-Mons V, Jara P, del Palacio A, Turrion VS, Barrios C, et al. Randomized trial of fluconazole versus nystatin for the prophylaxis of Candida infection following liver transplantation. J Infect Dis. 1996;174:583-8.
22. Meyers B, Papanicolaou G, Chodoff L, Sheiner P, Miller C, Mendelson M. A double-blind prospective controlled study of fluconazole vs. placebo in the prevention of fungal infections in patients undergoing orthotopic liver transplantation. In: Abstracts of the 37th Interscience Conference on Antimicrobial Agents and Chemotherapy. Washington, DC: American Society for Microbiology; 1997:306.
23. Rossi S, Ferguson M, Gortesky S, Gelhoi A, Schroeder T, Hano D. A randomized prospective trial of fluconazole vs. nystatin/clotrimazole for fungal prophylaxis in liver transplant recipients. In: Program and Abstracts of the 14th Annual Meeting of the American Society of Transplant Physicians. Chicago: American Society of Transplant Physicians; 1995:149.
24. Como JA, Dismukes WE. Oral azole drugs as systemic antifungal therapy. N Engl J Med. 1994;330:263-72.
25. Kahan BD. Cyclosporine. N Engl J Med. 1989;321:1725-38.
26. Back DJ, Tjia JF. Comparative effects of the antimycotic drugs ketoconazole, fluconazole, itraconazole and terbinafine on the metabolism of cyclosporin by human liver microsomes. Br J Clin Pharmacol. 1991;32:624-6.
27. Wingard JR, Merz WG, Rinaldi MG, Johnson TR, Karp JE, Saral R. Increase in Candida krusei infection among patients with bone marrow transplantation and neutropenia treated prophylactically with fluconazole. N Engl J Med. 1991;325:1274-7.
28. Wingard JR, Merz WG, Rinaldi MG, Miller CB, Karp JE, Saral R. Association of Torulopsis glabrata infections with fluconazole prophylaxis in neutropenic bone marrow transplant patients Antimicrob Agents Chemother. 1993;37:1847-9.
29. Abi-Said D, Anaissie E, Uzun O. Raad I, Pinzcowski H, Vartivarian S. The epidemiology of hematogenous candidiasis caused by different Candida species. Clin Infect Dis. 1997;24:1122-8.
30. Winston DJ, Chandrasekar PH, Lazarus HM, Goodman JL, Silber JL, Horowitz H, et al. Fluconazole prophylaxis of fungal infections in patients with acute leukemia. Results of a randomized placebo-controlled, double-blind, multicenter trial. Ann Intern Med. 1993;118:495-503.