Malignant chondroblastoma presenting as a recurrent pelvic tumor with DNA aneuploidy and p53 mutation as supportive evidence of malignancy

Skeletal Radiology

Volumn 28, Issue 11, 1999, Pages 644-650

  Ostrowski, Mary L ^a   Johnson, Mark E ^a   Truong, Luan D ^a   Hicks, M John ^a   Smith, Frank E ^a   Spjut, Harlan J ^a  

^a HOUSTON METHODIST HOSPITAL   (United States)

Author keywords

Aneuploidy; Chondroblastoma, malignant, recurrent; CT; Femur; p53 mutation; Pelvis; Xray

Indexed keywords

PROTEIN P53;

ADULT; ANEUPLOIDY; ARTICLE; CANCER CHEMOTHERAPY; CANCER RADIOTHERAPY; CASE REPORT; CELL PROLIFERATION; CHONDROBLASTOMA; DEATH; FEMUR FRACTURE; FLOW CYTOMETRY; GENE MUTATION; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LUNG METASTASIS; MALE; MALIGNANT NEOPLASTIC DISEASE; MITOSIS; PELVIS TUMOR; PRIORITY JOURNAL; RADIOLOGY; TUMOR BIOPSY; TUMOR RECURRENCE;

ANEUPLOIDY; BIOPSY; BONE NEOPLASMS; CHONDROBLASTOMA; DIAGNOSIS, DIFFERENTIAL; DNA, NEOPLASM; FATAL OUTCOME; FEMUR; FLOW CYTOMETRY; HUMANS; MALE; MIDDLE AGED; MUTATION; NEOPLASM RECURRENCE, LOCAL; PELVIC NEOPLASMS; PELVIS; TOMOGRAPHY, X-RAY COMPUTED; TUMOR SUPPRESSOR PROTEIN P53;

EID: 0032758162     PISSN: 03642348     EISSN: None     Source Type: Journal    
DOI: 10.1007/s002560050567     Document Type: Article

References (37)

1. Unni KK. Dahlin's bone tumors: general aspects and data on 11,087 cases, 5th edn. Philadelphia: Lippincott-Raven, 1996:143-183.
2. Schajowicz F, Gallardo H. Epiphyseal chondroblastoma of bone. A clinicopathological study of sixty nine cases. J Bone Joint Surg Br 1970; 52:205-226.
3. Huvos AG, Marcove RC. Chondroblastoma of bone: a critical review. Clin Orthop 1973; 95:300-312.
4. Bloem JL, Mulder JD. Chondroblastoma: a clinical and radiologie study of 104 cases. Skeletal Radiol 1985; 14:1-9.
5. Springfield DS, Capanna R, Gherlinzoni F, Picci P, Campanacci M. Chondroblastoma: a review of seventy cases. J Bone Joint Surg Am 1985; 67:748-755.
6. Kurt A-M, Unni KK, Sim FH, McLeod RA. Chondroblastoma of bone. Hum Pathol 1989; 20:965-976.
7. Turcotte RE, Kurt AM, Sim FH, Unni KK, McLeod RA. Chondroblastoma. Hum Pathol 1993; 24:944-949.
8. Dahlin DC, Ivins JC. Benign chondroblastoma: a study of 125 cases. Cancer 1972; 30:401-413.
9. Riddell RJ, Louis CJ, Bromberger NA. Pulmonary metastases from chondroblastoma of the tibia: report of a case. J Bone Joint Surg Br 1973; 55:848-853.
10. Green P, Whittaker RP. Benign chondroblastoma: case report with pulmonary metastasis. J Bone Joint Surg Am 1975; 57:418-420.
11. Huvos AG, Higinbotham NL, Marcove RC, O'Leary P. Aggressive chondroblastoma. Review of the literature on aggressive behavior and metastases with a report of one new case. Clin Orthop 1977; 126:266-272.
12. Wirman JA, Crissman JD, Aron BF. Metastatic chondroblastoma. Report of an unusual case treated with radiotherapy. Cancer 1979; 44:87-93.
13. Hatcher CH, Campbell JC. Benign chondroblastoma of bone: its histologic variation and report of late sarcoma in the site of one. Bull Hosp Joint Dis 1951; 12:411-430.
14. Steiner GC. Postradiation sarcoma of bone. Cancer 1965; 18:603-612.
15. Reyes CV, Kathuria S. Recurrent and aggressive chondroblastoma of the pelvis with late malignant neoplastic changes. Am J Surg Pathol 1979; 3:449-455.
16. Vindelov LL, Christensen IJ, Nissen NI. A detergent-trypsin method for the preparation of nuclei for flow cytometric DNA analysis. Cytometry 1983; 3:323-327.
17. Mirra JM. Bone tumors. Diagnosis and treatment. Philadelphia: JB Lippincott, 1980:219-234.
18. McLeod RA, Beabout JW. The roentgenographic features of chondroblastoma. AJR 1973; 118:464-471.
19. Matsuno T, Hasegawa I, Masuda T. Chondroblastoma arising from triradiate cartilage. Report of two cases with review of the literature. Skeletal Radiol 1987; 16:216-222.
20. Kyriakos M, Land VJ, Penning L, Parker SG. Metastatic chondroblastoma. Report of a fatal case with a review of the literature on atypical, aggressive, and malignant chondroblastoma. Cancer 1985; 55:1770-1789.
21. Kahn LB, Wood FM, Ackerman LV. Malignant chondroblastoma: report of two cases and review of the literature. Arch Pathol 1969; 88:371-376.
22. McLaughlin RE, Sweet RE, Webster T, Merritt WM. Chondroblastoma of the pelvis suggestive of malignany. J Bone Joint Surg Am 1975; 57:549-551.
23. Varma BP, Gupta IM. Atypical chondroblastoma of tibia. Report of a recurrent lesion. Clin Orthop 1972; 89:241-245.
24. Birch PJ, Buchanan R, Golding P, Pringle JAS. Chondroblasloma of the rib with widespread bone metastases. Histopathology 1994; 25; 583-585.
25. Ackerman LV, Spjut HJ. Atlas of tumor pathology: tumors of bone and cartilage. Washington: Armed Forces Institute of Pathology, 1962.
26. Fechner RE, Mills SE. Atlas of tumor pathology: tumors of the bones and joints. Washington: Armed Forces Institute of Pathology, 1993.
27. Coughlan B, Feliz A, Ishida T, Czerniak B, Dorfman H. p53 expression and DNA ploidy of cartilage lesions. Hum Pathol 1995; 26:620-624.
28. Wadayama B, Toguchida J, Yamaguchi T, Sasaki MS, Kotoura Y, Yamamuro T. p53 expression and its relationship to DNA alterations in bone and soft tissue sarcomas. Br J Cancer 1993; 68:1134-1139.
29. Hasegawa T, Seki K, Yang P, et al. Differentiation and proliferative activity in benign and malignant cartilage tumors of bone. Hum Pathol 1995; 26; 838-845.
30. Dobashi Y, Sugimura H, Sato A, et al. Possible association of p53 overexpression and mutation with high grade chondrosarcoma. Diagn Mol Pathol 1993; 2:257-263.
31. Cuvelier CA, Roels HJ. Cytomorphometric studies of the nuclear DNA content in cartilaginous tumors. Cancer 1979; 44:1363-1374.
32. El-Naggar AK, Hurr K, Tu N, et al. DNA and RNA content analysis by flow cytometry in the pathobiologic assessment of bone tumors. Cytometry 1995; 19:256-262.
33. Rodgers WB, Mankin HJ. Metastatic malignant chondroblastoma. Am J Orthop 1996; 12:846-849.
34. Alho A, Skjeldal S, Melvik JE, Pettersen EO, Larsen TE. The clinical importance of DNA synthesis and aneuploidy in bone and soft tissue tumors. Anti Cancer Res 1993; 13:2383-2388.
35. Sirsat MV, Doctor VM. Benign chondroblastoma of bone: report of a case of malignant transformation. J Bone Joint Surg Br 1970; 52:741-745.
36. Netherlands Committee on Bone Tumors. Radiologic atlas of bone tumors, vol 2. The Hague: Mouton, 1973; 311-326.
37. Posl M, Werner M, Amling M, Ritzel H, Delling G. Malignant transformation of chondroblastoma. Histopathology 1996; 29:477-480.