Pharmacologic approaches to therapy for casovagal syncope

American Journal of Cardiology

Volumn 84, Issue 8 SUPPL. 1, 1999, Pages 20-25

  Calkins, Hugh ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA ADRENERGIC RECEPTOR STIMULATING AGENT; ATENOLOL; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; CHOLINERGIC RECEPTOR BLOCKING AGENT; CLONIDINE; DEXAMPHETAMINE; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; DISOPYRAMIDE; ERYTHROPOIETIN; ETILEFRINE; FLUDROCORTISONE; FLUOXETINE; METHYLPHENIDATE; MIDODRINE; PAROXETINE; PLACEBO; PROPANTHELINE BROMIDE; PSEUDOEPHEDRINE; SCOPOLAMINE; SEROTONIN UPTAKE INHIBITOR; SERTRALINE; THEOPHYLLINE; VERAPAMIL;

BRONCHOSPASM; CARDIOTOXICITY; CLINICAL PROTOCOL; CLINICAL TRIAL; DRUG EFFICACY; FATIGUE; FLUID INTAKE; GASTROINTESTINAL TOXICITY; HUMAN; HYPERTENSION; INTRAVENOUS DRUG ADMINISTRATION; NEUROTOXICITY; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; REVIEW; SALT INTAKE; SKIN MANIFESTATION; SYNCOPE; TILT TABLE TEST; TREATMENT PLANNING; URINE RETENTION;

EID: 0032755397     PISSN: 00029149     EISSN: None     Source Type: Journal    
DOI: 10.1016/s0002-9149(99)00626-8     Document Type: Review

References (39)

1. El-Sayed H, Hainsworth R. Salt supplement increases plasma volume and orthostatic tolerance in patients with unexplained syncope. Heart. 75:1996;134-140.
2. Younoszai A.K., Franklin W.H., Chan D.P., Cassidy S.C., Allen H.D. Oral fluid therapy a promising treatment for vasodepressor syncope . Arch Pediatr Adolesc Med. 152:1998;165-168.
3. Sheldon R., Rose S., Flanagan P., Koshman M.L., Killam S. Effect of beta blockers on the time to first syncope recurrence in patients after a positive isoproterenol tilt-table test. Am J Cardiol. 78:1996;536-539.
4. Slotwiner D.J., Stein K.M., Lippman N., Markowitz S.M., Lerman B.B. Response of neurocardiac syncope to beta-blocker therapy interaction between age and parasympathetic tone . PACE Pacing Clin Electrophysiol. 20:1997;810-814.
5. Scott W.A., Pongiglione G., Bromberg B.I., Schaffer M.S., Deal B.J., Fish F.A., Dick M. Randomized comparison of atenolol and fludrocortisone acetate in the treatment of pediatric neurally mediated syncope. Am J Cardiol. 76:1995;400-402.
6. Biffi M., Boriani G., Sabbatani P., Bronzetti G., Frabetti L., Zannoli R., Branzi A., Magnani B. Malignant vasovagal syncope a randomised trial of metoprolol and clonidine . Heart. 77:1997;268-272.
7. Klingenheben T., Kalusche D., Li Y.G., Schopperl M., Hohnloser S.H. Changes in plasma epinephrine concentration and in heart rate during head-up tilt testing in patients with neurocardiogenic syncope correlation with successful therapy with beta-receptor antagonists . J Cardiovasc Electrophysiol. 7:1996;802-808.
8. Cox M.M., Perlman B.A., Mayor M.R., Silberstein T.A., Levin E., Pringle L., Castellanos A., Myerburg R.J. Acute and long-term β-adrenergic blockade for patients with neurocardiogenic syncope. J Am Coll Cardiol. 26:1995;1293-1298.
9. Cohen M.B., Snow J.S., Grasso V., Lehnert L., Goldner B.G., Jadonath R.L., Cohen T.J. Efficacy of pindolol for treatment of vasovagal syncope. Am Heart J. 130:1995;786-790.
10. Sra J.S., Murthy V.S., Jazayeri M.R., Shen Y.H., Troup P.J., Avitall B., Akhtar M. Use of intravenous esmolol to predict efficacy of oral beta-adrenergic blocker therapy in patients with neurocardiogenic syncope. J Am Coll Cardiol. 19:1992;402-408.
11. Grubb B.P., Temesy-Armos P., Moore J., Wolfe D., Hahn H., Elliott L. The use of head-upright tilt table testing in the evaluation and management of syncope in children and adolescents. PACE Pacing Clin Electrophysiol. 15:1992;742-748.
12. Natale A., Sra J., Dhala A., Wase A., Jazayeri M., Deshpande S., Blanck Z., Akhtar M. Efficacy of different treatment strategies for neurocardiogenic syncope. PACE Pacing Clin Electrophysiol. 18:1995;655-662.
13. Mahanonda N., Bhuripanyo K., Kangkagate C., Wansanit K., Kulchot B., Nademanee K., Chaithiraphan S. Randomized double-blind, placebo-controlled trial of oral atenolol in patients with unexplained syncope and positive upright tilt table test results. Am Heart J. 130:1995;1250-1253.
14. Bannister R. Multiple system atrophy and pure autonomic failure. Low P. Clinical Autonomic Disorders. 1993;517-525 Little Brown & Co, Boston.
15. Mion D. Jr, Rea R.F., Anderson E.A., Kahn D., Sinkey C.A., Mark A.L. Effects of fludrocortisone on sympathetic nerve activity in humans. Hypertension. 23:1994;123-130.
16. Jankovic J., Hiner B.C., Brown D.C. Neurogenic orthostatic hypotension a double-blind, placebo-controlled study with midodrine . Am J Med. 95:1993;38-48.
17. Ward C.R., Gray J.C., Gilroy J.J., Kenny R.A. Midodrine a role in the management of neurocardiogenic syncope . Heart. 79:1998;45-49.
18. Sra J., Maglio C., Biehl M., Dhala A., Blanck Z., Deshpande S., Jazayeri M.R., Akhtar M. Efficacy of midodrine hydrochloride in neurocardiogenic syncope refractory to standard therapy. J Cardiovasc Electrophysiol. 8:1997;42-46.
19. Raviele A., Themistoclakis S., Gasparini G. Drug treatment of vasovagal syncope. Blanc J.-J., Benditt D., Sutton R. Neurally Mediated Syncope Pathophysiology, Investigations, and Treatment . 1996;113-117 Futura Publishing Company, Armonk, NY.
20. Raviele A., Brignole M., Sutton R., Alboni P., Giani P., Menozzi C., Moya A. Effect of etilefrine in preventing syncopal recurrence in patients with vasovagal syncope a double-blind, randomized, placebo-controlled trial . Circulation. 99:1999;1452-1457.
21. Strieper M.J., Campbell R.M. Efficacy of alpha-adrenergic agonist therapy for prevention of pediatric neurocardiogenic syncope. J Am Coll Cardiol. 22:1993;594-597.
22. Grubb B.P., Kosinski D., Mouhaffel A., Pothoulakis A. The use of methylphenidate in the treatment of refractory neurocardiogenic syncope. PACE Pacing Clin Electrophysiol. 19:1996;836-840.
23. Susmano A., Volgman A.S., Buckingham T.A. Beneficial effects of dextro-amphetamine in the treatment of vasodepressor syncope. PACE Pacing Clin Electrophysiol. 16:1993;1235-1239.
24. Girolamo E.D., Iorio C.D., Sabatini P., Leonzio L., Barbone C., Barsotti A. Effects of paroxetine hydrochloride, a selective serotonin reuptake inhibitor, on refractory vasovagal syncope a randomized, double-blind, placebo-controlled study . J Am Coll Cardiol. 33:1999;1227-1230.
25. Grubb B.P., Wolfe D.A., Samoil D., Temesy-Armos P., Hahn H., Elliott L. Usefulness of fluoxetine hydrochloride for prevention of resistant upright tilt induced syncope. PACE Pacing Clin Electrophysiol. 16:1993;458-464.
26. Grubb B.P., Samoil D., Kosinski D., Kip K., Brewster P. Use of sertraline hydrochloride in the treatment of refractory neurocardiogenic syncope in children and adolescents. J Am Coll Cardiol. 24:1994;490-494.
27. Lenk M., Alehan D., Ozme S., Celiker A., Ozer S. The role of serotonin re-uptake inhibitors in preventing recurrent unexplained childhood syncope - a preliminary report. Eur J Pediatrics. 156:1997;747-750.
28. Tandan T., Giuffre M., Sheldon R. Exacerbation of neurally mediated syncope associated with sertraline. Lancet. 349:1997;1145-1146.
29. Morillo C.A., Leitch J.W., Yee R., Klein G.J. A placebo-controlled trial of intravenous and oral disopyramide for prevention of neurally mediated syncope induced by head-up tilt. J Am Coll Cardiol. 22:1993;1843-1848.
30. Milstein S., Buetikofer J., Dunnigan A., Benditt D.G., Gornick C., Reyes W.J. Usefulness of disopyramide for prevention of upright tilt-induced hypotension-bradycardia. Am J Cardiol. 65:1990;1339-1344.
31. Leor J., Rotstein Z., Vered Z., Kaplinsky E., Truman S., Eldar M. Absence of tachycardia during tilt test predicts failure of beta-blocker therapy in patients with neurocardiogenic syncope. Am Heart J. 127:1994;1539-1543.
32. Sra J.S., Jazayeri M.R., Avitall B., Dhala A., Deshpande S., Blanck Z., Akhtar M. Comparison of cardiac pacing with drug therapy in the treatment of neurocardiogenic (vasovagal) syncope with bradycardia or asystole. N Engl J Med. 328:1993;1085-1090.
33. Grubb B.P., Temesy-Armos P., Hahn H., Elliott L. Utility of upright tilt-table testing in the evaluation and management of syncope of unknown origin. Am J Med. 90:1991;6-10.
34. Lee T.M., Su S.F., Chen M.F., Liau C.S., Lee Y.T. Usefulness of transdermal scopolamine for vasovagal syncope. Am J Cardiol. 78:1996;480-482.
35. Yu J.C., Sung R.J. Clinical efficacy of propantheline bromide in neurocardiogenic syncope pharmacodynamic implications . Cardiovasc Drugs Ther. 10:1997;687-692.
36. Corbala F., Pacheco U.A., Pedraza I.S., Garate V., Manzana M.L., Miranda L., Carrillo C.A., Haro G.L. Vasovagal syncope management with propantheline bromide . Arch Inst Cardiol Mex. 67:1997;227-230.
37. Nelson S.D., Stanley M., Love C.J., Coyne K.S., Schaal S.F. The autonomic and hemodynamic effects of oral theophylline in patients with vasodepressor syncope. Arch Intern Med. 151:1991;2425-2429.
38. Lee T.M., Chen M.F., Su S.F., Chao C.L., Liau C.S., Lee Y.T. Excessive myocardial contraction in vasovagal syncope demonstrated by echocardiography during head-up tilt test. Clin Cardiol. 19:1996;137-140.
39. Lopez C.J., Pico A.F., Sanchez M.J. Malignant vasovagal syncope its diagnosis and therapeutic trial based on the orthostatism test (the tilt-table test) . Rev Esp Cardiol. 46:1993;28-33.