Linkage analysis in heterogeneous and complex traits

European Child and Adolescent Psychiatry

Volumn 8, Issue SUPPL. 3, 1999, Pages 43-46

  Ott, Jurg ^a   Bhat, Ajita ^a  

^a ROCKEFELLER UNIVERSITY   (United States)

Author keywords

Ascertainment; Genetic heterogeneity; Linkage analysis

Indexed keywords

ARTICLE; GENE LOCUS; GENETIC ANALYSIS; GENETIC HETEROGENEITY; GENETIC LINKAGE; HUMAN; INHERITANCE; PHENOTYPE; SIBLING;

EID: 0032754452     PISSN: 10188827     EISSN: None     Source Type: Journal    
DOI: 10.1007/pl00010693     Document Type: Article

References (17)

1. Clerget-Darpoux F, Bonaïti-Pellié C, Hochez J (1986) Effects of misspecifying genetic parameters in lod score analysis. Biometrics 42:393-399
2. Curtis D, Sham PC (1995) Model-free linkage analysis using likelihoods. Am J Hum Genet 57:703-716
3. Dubay C, Vincent M, Samani NJ, Hilbert P, Kaiser MA, Beressi JP, Kotelevtsev Y, Beckmann JS, Soubrier F. Sassard J, et al (1993) Genetic determinants of diastolic and pulse pressure map to different loci in Lyon hypertensive rats. Nature Genetics 3:354-357
4. Dyck PJ, Ott J, Moore SB, Swanson CJ, Lambert EH (1983) Linkage evidence for genetic heterogeneity among kinships with hereditary motor and sensory neuropathy, type I. Mayo Clin Proc 58:430-435
5. Fu L (1994) Polygenic trait analysis by neural network learning. Artif Intell Med 6:51-65
6. Grigorenko EL, Wood FB, Meyer MS, Hart LA, Speed WC, Shuster A, Pauls DL (1997) Susceptibility loci for distinct components of developmental dyslexia on chromosomes 6 and 15. Am J Hum Genet 60:27-39
7. Johnson NL, Kotz S (1972) Distributions in Statistics: Continuous Multivariate Distributions. Wiley, New York
8. Kidd KK, Ott J (1984) Power and sample size in linkage studies. Cytogenet Cell Genet 37:510-511
9. Lucek PR, Ott J (1997) Neural network analysis of complex traits. Genet Epidemiol 14:1101-1106
10. Ott J (1979) Ascertainment in the Seattle lipid studies. In: Sing CF, Skolnick M (eds) Genetic Analysis of Common Diseases and Applications to Predictive Factors in Coronary Disease. New York, Alan R. Liss, pp 383-388
11. rd edition. Johns Hopkins University Press, Baltimore
12. Ott J (1997) Genetic mapping of complex disorders. In: Pawlowitzki 1-H, Edwards JH, Thompson EA (eds) Genetic Mapping of Disease Genes. Associated Press, New York
13. Rice JP, Goate A, Williams JT, Bierut L, Dorr D, Wu W, Shears S, Gopalakrishnan G, Edenberg HJ, Foroud T, Nurnberger J Jr, Gershon ES, Detera-Wadleigh SD, Goldin LR, Guroff JJ, McMahon FJ, Simpson S, MacKinnon D, McInnis M, Stine OC, DePaulo JR, Blehar MC, Reich T (1997) Initial genome scan of the NIMH genetics initiative bipolar pedigrees: Chromosomes 1, 6, 8, 10, and 12. Am J Med Genet 74:247-253
14. Risch N, Gosh S, Todd JA (1993) Statistical evaluation of multiple-locus linkage data in experimental species and its relevance to human studies: application to nonobese diabetic (NOD) mouse and human insulin-dependent diabetes mellitus (IDDM). Am J Hum Genet 53:702-714
15. Risch N, Giuffra L (1992) Model misspecification and multipoint linkage analysis. Hum Hered 42:77-92
16. Schork NJ, Boehnke M, Terwilliger JD, Ott J (1993) Two-trait-locus linkage analysis: a powerful strategy for mapping complex genetic traits. Am J Hum Genet 53:1127-1136
17. Weeks DE, Lehner T, Squires-Wheeler E, Kaufmann C, Ott J (1990) Measuring the inflation of the lod score due to its maximization over model parameter values in human linkage analysis. Genet Epidemiol 7:237-243