Repair of the damaged brain. The Alfred Meyer Memorial Lecture 1998

Neuropathology and Applied Neurobiology

Volumn 25, Issue 5, 1999, Pages 351-362

  Dunnett, S B ^a,b  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^b UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

Cognitive deficits; Functional recovery; Huntington's disease; Motor deficits; Neural transplantation; Nigral grafts; Parkinson's disease; Striatal grafts

Indexed keywords

BRAIN INJURY; CHRONIC PAIN; HUNTINGTON CHOREA; MULTIPLE SCLEROSIS; NERVE TRANSPLANTATION; PARKINSON DISEASE; PRIORITY JOURNAL; REVIEW; SPINAL CORD INJURY;

ANIMALS; BRAIN; CORPUS STRIATUM; FETAL TISSUE TRANSPLANTATION; HUNTINGTON DISEASE; PARKINSON DISEASE; SUBSTANTIA NIGRA;

EID: 0032751639     PISSN: 03051846     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2990.1999.00207.x     Document Type: Review

References (69)

1. 1 Aguayo AJ, Björklund A, Stenevi U, Carlstedt T. Fetal mesencephalic neurons survive and extend long axons across peripheral nervous system grafts inserted into the adult rat striatum. Neurosci Lett 1984; 45: 53-8
2. 2 Alexander GE, DeLong MR, Strick PL. Parallel organization of functionally segregated circuits linking basal ganglia and cortex. Ann Rev Neurosci 1986; 9: 357-81
3. 3 Altman J, Das GD. Autoradiographic and histological evidence of postnatal hippocampal neurogenesis in rats. J Comp Neurol 1965; 124: 319-36
4. 4 Becker JB, Robinson TE, Barton P, Sintov A, Siden R, Levy RJ. Sustained behavioral recovery from unilateral nigrostriatal damage produced by the controlled release of dopamine from a silicone polymer pellet placed into the denervated striatum. Brain Res 1990; 508: 60-4
5. 5 Björklund A, Campbell K, Sirinathsinghji DJS, Fricker RA, Dunnett SB. Functional capacity of striatal transplants in the rat Huntington model. In Functional Neural Transplantation, Eds. SB Dunnett, A Björklund. New York: Raven Press, 1994; 157-95
6. 6 Björklund A, Dunnett SB, Stenevi U, Lewis ME, Iversen SD. Reinnervation of the denervated striatum by substantia nigra transplants: functional consequences as revealed by pharmacological and sensorimotor testing. Brain Res 1980; 199: 307-33
7. 7 Björklund A, Schmidt RH, Stenevi U. Functional reinnervation of the neostriatum in the adult rat by use of intraparenchymal grafting of dissociated cell suspensions from the substantia nigra. Cell Tiss Res 1980; 212: 39-45
8. 8 Björklund A, Stenevi U. Growth of central catecholamine neurones into smooth muscle grafts in the rat mesencephalon. Brain Res 1971; 31: 1-20
9. 9 Björklund A, Stenevi U. Reconstruction of the nigrostriatal dopamine pathway by intracerebral transplants. Brain Res 1979; 177: 555-60
10. 10 Björklund A, Stenevi U. Neural Grafting in the Mammalian CNS Amsterdam: Elsevier, 1985
11. 11 Björklund A, Stenevi U, Schmidt RH, Dunnett SB, Gage FH. Intracerebral grafting of neuronal cell suspensions, II. Survival and growth of nigral cell suspensions implanted in different brain sites. Acta Physiol Scand Suppl 1983; 522: 9-18
12. 12 Bohn MC, Cupit L, Marciano F, Gash DM. Adrenal grafts enhance recovery of striatal dopaminergic fibers. Science 1987; 237: 913-6
13. 13 Brecknell JE, Du J-S, Muir EM et al. Bridge grafts of fibroblast growth factor-4-secreting Schwannoma cells promote functional axonal regeneration in the nigrostriatal pathway of the adult rat. Neuroscience 1996; 74: 775-84
14. 14 Brecknell JE, Haque NSK, Du J-S et al. Functional and anatomical reconstruction of the 6-OHDA lesioned nigrostriatal system of the adult rats by RN22 nigrostriatal bridge grafts. Neuroscience 1996; 71: 913-25
15. 15 Brown VJ, Dunnett SB. Comparison of adrenal and fetal nigral grafts on drug-induced rotation in rats with 6-OHDA lesions. Exp Brain Res 1989; 78: 214-8
16. 16 Brundin P, Duan W-M, Sauer H. Functional effects of mesencephalic dopamine neurons and adrenal chromaffin cells grafted to the rodent striatum. In Functional Neural Transplantation, Eds. SB Dunnett, A Björklund. New York: Raven Press, 1994: 9-46
17. 17 Brundin P, Strecker RE, Widner H et al. Human fetal dopamine neurons grafted in a rat model of Parkinson's disease: immunological aspects, spontaneous and drug-induced behavior, and dupamine release. Exp Brain Res 1988; 70: 192-208
18. 18 Cajal SRY. Degeneration and Regeneration of the Nervous System. Oxford: Oxford University Press, 1928
19. 19 Cavanagh JB. Alfred Meyer MD. Obituary. Neuropathol Appl Neurobiol 1991; 17: 83-7
20. 20 Clarke DJ, Dunnett SB. Synaptic relationships between cortical and dopaminergic inputs and intrinsic GABAergic systems within intrastriatal striatal grafts. J Chem Neuroanat 1993; 6: 147-58
21. 21 Coyle JT, Schwarcz R. Lesions of striatal neurones with kainic acid provides a model for Huntington's chorea. Nature 1976; 263: 244-6
22. 22 Divac I, Markowitsch HJ, Pritzel M. Behavioural and anatomical consequences of small intrastriatal injections of kainic acid in the rat. Brain Res 1978; 151: 523-32
23. 23 Divac I, Rosvold HE, Szwarcbart MK. Behavioral effects of selective ablation of the caudate nucleus. J Comp Pbysiol Psychol 1967; 63: 184-90
24. 24 Döbrössy MD, Dunnett SB. Striatal grafts alleviate deficits in response execution in a lateralised reaction time task. Brain Res Bull 1998; 47: 585-93
25. 25 Dunnett SB. Transplantation of embryonic dopamine neurons: what we know from rats? J Neurol 1991; 238: 65-74
26. 26 Dunnett SB. Functional repair of striatal systems by neural transplants: evidence for circuit reconstruction. Behav Brain Res 1995; 66: 133-42
27. 27 Dunnett SB, Annett LE, Kendall AL, Rosser AE, Watts C, Svendsen CN. Sources of cells for transplantation and gene therapy in Parkinson's disease. In Neurochemistry, Eds. AW Teelken, J Korf. New York: Plenum Press, 1997: 249-57
28. 28 Dunnett SB, Björklund A. Functional Neural Transplantation. New York: Raven Press 1994
29. 29 Dunnett SB, Björklund A. Mechanisms of function of neural grafts in the injured brain. In Functional Neural Transplantation, Eds. SB Dunnett, A Björklund. New York: Raven Press, 1994: 531-67
30. 30 Dunnett SB, Hernandez TD, Summerfield A, Jones GH, Arbuthnott GW. Graft-derived recovery from 6-OHDA lesions: specificity of ventral mesencephalic graft tissues. Exp Brain Res 1988; 71: 411-24
31. 31 Dunnett SB, Isacson O, Sirinathsinghji DJS, Clarke DJ, Björklund A. Striatal grafts in rats with unilateral neostriatal lesions. III. Recovery from dopamine-dependent motor asymmetry and deficits in skilled paw reaching. Neuroscience 1988; 24: 813-20
32. 32 Dunnett SB, Rogers DC, Richards SJ. Nigrostriatal reconstruction after 6-OHDA lesions in rats: combination of dopamine-rich nigral grafts and nigrostriatal bridge grafts. Exp Brain Res 1989; 75: 523-35
33. 33 Fawcett JW, Barker RA, Dunnett SB. Dopaminergic neuronal survival and the effects of bFGF in explant, three-dimensional and monolayer cultures of embryonic rat ventral mesencephalon. Exp Brain Res 1995; 106: 275-82
34. 34 Freed WJ, Morihisa JM, Spoor E et al. Transplanted adrenal chromaffin cells in rat brain reduce lesion-induced rotational behavior. Nature 1981; 292: 351-2
35. 35 Hargraves RW, Freed WJ. Chronic intrastriatal dopamine infusions in rats with unilateral lesions of the substantia nigra. Life Sci 1987; 40: 959-66
36. 36 Horellou P, Lundberg C, Lebourdelles B et al. Behavioural effects of genetically engineered cells releasing DOPA and dopamine after intracerebral grafting in a rat model of Parkinson's disease. J Physiol (Paris) 1991; 85: 158-70
37. 37 Isacson O, Dunnett SB, Björklund A. Graft-induced behavioral recovery in an animal model of Huntington disease. Proc Natl Acad Sci USA 1986; 83: 2728-32
38. 38 Labandeira-Garcia JL, Guerra MJ. Cortical stimulation induces fos expression in intrastriatal striatal grafts. Brain Res 1994; 652: 87-97
39. 39 Labandeira-Garcia JL, Wictorin K, Cunningham ET, Björklund A. Development of intrastriatal striatal grafts and their afferent innervation from the host. Neuroscience 1991; 42: 407-26
40. 40 Le Gros Clark WE. Neuronal differentiation in implanted foetal cortical tissue. J Neurol Psychiat 1940; 3: 263-84
41. 41 Le Gros Clark WE. The problem of neuronal regeneration in the central nervous system. I. The influence of spinal ganglia and nerve fragments grafted in the brain. J Anat 1942; 77: 20-48
42. 42 LeVere TE, LeVere ND. Transplants to the central nervous system as a therapy for brain pathology, Neurobiol Aging 1985; 6: 151-2
43. 43 Lindvall O. Neural transplantation: a hope for patients with Parkinson's disease? Neuroreport 1997; 8: iii-x
44. 44 Marsden CD, Linazasoro G, Obeso JA. An introduction to the new surgery for Parkinson's disease: past and present problems. Adv Neurol 1997; 74: 143-7
45. 45 Marsden CD, Parkes JD. Success and problems of long-term levodopa therapy in Parkinson's disease. Lancet 1977; 1: 345-9
46. 46 Mason ST, Sanberg PR, Fibiger HC. Kainic acid lesions of the striatum dissociate amphetamine and apomorphine stereotypy: similarities to Huntington's chorea. Science 1978; 201: 352-5
47. 47 Mayer E, Brown VJ, Dunnett SB, Robbins TW. Striatal graft-associated recovery of a lesion-induced performance deficit in the rat requires learning to use the transplant. Eur J Neurosci 1992; 4: 119-26
48. 48 Meyer A. Early professional reminiscences. Neuropathol Appl Neurobiol 1988; 14: 431-42
49. 49 Meyers R. The modification of alternating tremors, rigidity and festination by surgery of basal ganglia. Assoc Nerv Ment Dis Proc 1942; 21: 602-65
50. 50 Meyers R. Surgical experiments in therapy of certain 'extra-pyramidal' diseases: current evaluation. Acta Psychiat Neurol Suppl 1951; 67: 1-42
51. 51 Montoya CP, Astell S, Dunnett SB. Effects of nigral and striatal grafts on skilled forelimb use in the rat. Prog Brain Res 1990; 82: 459-66
52. 52 Nakao N, Frodl EM, Duan W-M, Widner H, Brundin P. Lazaroids improve the survival of grafted rat embryonic dopamine neurons. Proc Natl Acad Sci USA 1994; 91: 12408-12
53. 53 Olanow CW, Freeman TB, Kordower JH. Transplantation strategies for Parkinson's disease. In Movement Disorders. Neurological Principles and Practice, Eds. RL Watts WC Koller. New York: McGraw-Hill, 1997: 221-36
54. 54 Olanow CW, Kordower JH, Freeman TB. Fetal nigral transplantation as a therapy for Parkinson's disease. Trends Neurosci 1996; 19: 102-9
55. 3H-noradrenaline uptake studies using tissue transplantation to the anterior chamber of the eye. Acta Physiol Scand Suppl 1970; 348: 1-112
56. 56 Perlow MJ, Freed WJ, Hoffer BJ, Seiger Å, Olson L, Wyatt RJ. Brain grafts reduce motor abnormalities produced by destruction of nigrostriatal dopamine system. Science 1979; 204: 643-7
57. 57 Quinn NP. The clinical application of cell grafting techniques in patients with Parkinson's disease. Prog Brain Res 1990; 82: 619-25
58. 58 Raisman G. Neuronal plasticity in the septal nuclei of the adult brain. Brain Res 1969; 14: 25-48
59. 59 Reading PJ, Torres EM, Dunnett SB. Embryonic striatal grafts ameliorate the disinhibitory effects of ventral striatal lesions. Exp Brain Res 1995; 105: 76-86
60. 60 Rosvold HE. The frontal lobe system: cortical-subcortical interrelationships. Acta Neurobiol Exp 1972; 32: 439-60
61. 61 Rutherford A, Garcia-Munoz M, Dunnett SB, Arbuthnott GW. Electrophysiological demonstration of host cortical inputs to striatal grafts. Neurosci Lett 1987; 83: 275-81
62. 62 Sanberg PR, Coyle JT. Scientific approaches to Huntington's disease. CRC Crit Rev Clin Neurobiol 1984; 1: 1-44
63. 63 Schwarcz R, Coyle JT. Striatal lesions with kainic acid: neurochemical characteristics. Brain Res 1977; 127: 235-49
64. 64 Schwarcz R, Hökfelt T, Fuxe K, Jonsson G, Goldstein M, Terenius L. Ibotenic acid-induced neuronal degeneration: a morphological and neurochemical study. Exp Brain Res 1979; 37: 199-216
65. 65 Sirinathsinghji DJS, Dunnett SB, Isacson O, Clarke DJ, Kendrick K, Björklund A. Striatal grafts in rats with unilateral neostriatal lesions. II. In vivo monitoring of GABA release in globus pallidus and substantia nigra. Neuroscience 1988; 24: 803-11
66. 66 Starr PA, Vitek JL, Bakay RAE. Ablative surgery and deep brain stimulation for Parkinson's disease. Neurosurgery 1998; 43: 989-1013
67. 67 Ungerstedt U. Striatal dopamine release after amphetamine or nerve degeneration revealed by rotational behaviour. Acta Physiol Scand Suppl 1971; 367: 49-68
68. 68 Wictorin K. Anatomy and connectivity of intrastriatal striatal transplants. Prog Neurobiol 1992; 38: 611-39
69. 69 Wilson CJ, Xu ZC, Emson PC, Feler C. Anatomical and physiological properties of the cortical and thalamic innervutions of neostriatal tissue grafts. Prog Brain Res 1990; 82: 417-26