Cardioprotective effects of abciximab (ReoPro®) in an isolated perfused rat heart model of ischemia and reperfusion

Methods and Findings in Experimental and Clinical Pharmacology

Volumn 21, Issue 8, 1999, Pages 529-534

  Campbell, B ^a   Chuhran, C M ^a   Lefer, D J ^a   Lefer, Allan M ^a  

^a THOMAS JEFFERSON UNIVERSITY   (United States)

Author keywords

Cell adhesion molecules; Contractile function; Myocardium; Neutrophils; Platelets

Indexed keywords

ABCIXIMAB;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CORONARY ARTERY BLOOD FLOW; DRUG EFFICACY; DRUG POTENCY; HEART LEFT VENTRICLE DP-DT; HEART LEFT VENTRICLE PRESSURE; HEART MUSCLE CONTRACTILITY; HEART MUSCLE ISCHEMIA; HEART PROTECTION; NEUTROPHIL; NONHUMAN; RAT; REPERFUSION INJURY;

ANESTHESIA; ANIMALS; ANTIBODIES, MONOCLONAL; BLOOD PLATELETS; CORONARY CIRCULATION; HEART; IMMUNOGLOBULIN FAB FRAGMENTS; MALE; MYOCARDIAL CONTRACTION; MYOCARDIUM; NEUTROPHILS; PERFUSION; PLATELET AGGREGATION INHIBITORS; RATS; RATS, SPRAGUE-DAWLEY; REPERFUSION INJURY; VENTRICULAR PRESSURE;

EID: 0032749567     PISSN: 03790355     EISSN: None     Source Type: Journal    
DOI: 10.1358/mf.1999.21.8.794834     Document Type: Article

References (34)

1. Tsao, P.S., Aoki, N., Lefer, D.J., Johnson III, I.G., Lefer, A.M. Time course of endothelial dysfunction and myocardial injury during myocardial ischemia and reperfusion in the cat. Circulation 1990, 82: 1402-12.
2. Forinan, M.B., Kolodgie, F.D., Jenkins, M., Virmani, R. Endothelial and myocardial injury during ischemia and reperfusion: Pathogenesis and therapeutic implications. J Am Coll Cardiol 1993, 21: 1245-53.
3. Entman, M.L., Michael, L., Rossen, R.D. et al. Inflammation in the course of early myocardial ischemia. FASEB J 1991, 5: 2529-37.
4. Engler, R.L., Schmid-Schónbein, G.W., Pavlec, R.S. Leukocyte capillary plugging in myocardial ischemia and reperfusion in the dog. Am J Pathol 1983, 111: 98-111.
5. Lefer, A.M., Tsao, P.S., Lefer, D.J., Ma, X-L. Role of endothelial dysfunction in the pathogenesis of reperfusion injury after myocardial ischemia. FASEB J 1991, 5: 2029-34.
6. Weiss, S.J. Tissue destruction by neutrophils. N Engl J Med 1989, 320: 365-76.
7. Buerke, M., Weyrich, A.S., Lefer, A.M. Isolated cardiac myocytes are sensitized by hypoxia-reoxygenation to neutrophil released mediators. Am J Physiol 1994, 266: H128-36.
8. Romson, J.L., Hook, B.G.F., Kunkel, S.L. et al. Reduction of the extent of ischemic myocardial injury by neutrophil depletion in the dog. Circulation 1983, 67: 1016-23.
9. Ma, X-I., Lefer, D.J., Lefer, A.M., Rothlein, R. Coronary endothelial and cardiac protective effects of a monoclonal antibody to intercellular adhesion molecule-1 in myocardial ischemia and reperfusion. Circulation 1992, 86: 937-46.
10. Weyrich, A.S., Ma, X-I., Lefer, D.J., Albertine, K.H., Lefer, A.M. In vivo neutralization of P-selectin protects feline heart and endothelium in myocardial ischemia and reperfusion injury. J Clin Invest 1993, 91: 2620-29.
11. Lefer, A.M., Weyrich, A.S., Buerke, M. Role of selectins: A new family of adhesion molecules, in ischaemia-reperfusion injury. Cardiovasc Res 1994, 28: 289-94.
12. 2 integrin CD11b/CD18. Blood 1996, 88: 4183-94.
13. 2-integrin CD11b/CD18. Blood 1996, 88: 146-57.
14. Entman, M.L., Ballantyne, C.M. Association of neutrophil with platelet aggregation in unstable angina: Should we alter therapy? Circulation 1996, 94: 1206-8.
15. Neumann, F-J., Marx, N., Gawax, M. et al. Induction of cytokine expression in leukocytes by binding of thrombin-stimulated platelets. Circulation 1997, 95: 2387-94.
16. Rinder, C.S., Bonana, J.L., Rinder, H.M., Mathew, J., Hines, R., Smith, B.R. Cardiopulmonary bypass induces leukocyte-platelet adhesion. Blood 1992, 79: 1201-5.
17. Simmons, M.L., Jan de Boer, M., van den Brand, M.J.B.M., van Miltenburg, A.J.M., Hoomtje, J.C.A., Heyndrickx, G.R., van der Weiken, L.R., De Bono, D., Rutsch, W., Schaible, T.F., Weisman, B.F., Klootwijk, P., Nijssen, K.M., Stibbe, J., de Feyter, P.J. and the European Study Group. Randomized trial of a GPIIb/IIIa platelet receptor blocker in refractory unstable angina. Circulation 1994, 89: 596-603.
18. González-Fernandez, F., López-Farré, A., Rodriguez-Feo, J. et al. Expression of inducible nitric oxide synthase after endothelial denudation of the rat carotid artery: Role of platelets. Circ Res 1998, 83: 1080-87.
19. Pabla, R., Buda, A.J., Flynn, D.M. et al. Nitric oxide attenuates neutrophil-mediated myocardial contractile dysfunction after ischemia and reperfusion. Circ Res 1996, 78: 65-72.
20. Lefer, D.J., Scalia, R., Campbell, B. et al. Peroxynitrite inhibits leukocyte-endothelial cell interactions and protects against ischemia-reperfusion injury in rats. J Clin Invest 1997, 99: 684-91.
21. Williams, J.H. Jr., Moser, K.M., Ulich, T., Cairo, M.S. Harvesting the circulating pool of polymorphonuclear leukocytes by hetastarch exchange transfusion (HET): Yield and function assessment. J Leuko Biol 1987, 42: 455-62.
22. Engler, R.L., Dahlgren, M.D., Morris, D.D., Paterson, M.A., Schmid-Schónbein, G.W. Role of leukocytes in response to acute myocardial ischemia and reflow in dogs. Am J Physiol 1986, 251: H314-23.
23. Smedly, L.A., Tonnesen, M.G., Sandhaus, R.A. et al. Neutrophil-mediated injury to endothelial cells. Enhancement by endotoxin and essential role of neutrophil elastase. J Clin Invest 1986, 77: 1233-43.
24. Entman, M.L., Smith, C.W. Postreperfusion inflammation: A model for reaction to injury in cardiovascular disease. Cardiovasc Res 1994, 28: 1301-11.
25. Butcher, E.C. Leukocyte-endothelial cell recognition: Three (or more) steps to specificity and diversity. Cell 1991, 67: 1033-6.
26. Kishimoto, T.K., Jutila, M.A., Butcher, E.C. Identification of a human peripheral lymph node homing receptor: A rapidly down-regulated adhesion molecule. Proc Natl Acad Sci USA 1990, 87: 2244-8.
27. Vaporciyan, A., DeLisser, A., Yan, H.M. et al. Involvement of platelet-endothelial cell adhesion molecule-1 in neutrophil recruitment in vivo. Science (Washington, D.C.) 1993, 262: 1580-2.
28. Rubanyi, G.M., Vanhoutte, P.M. Oxygen derived free radicals, endothelium and responsiveness of vascular smooth muscle. Am J Physiol 1986, 250: H815-21.
29. Larsen, E., Celi, A., Gilbert, G.E. et al. PADGEM protein: A receptor that mediates the interaction of activated platelets with neutrophils and monocytes. Cell 1989, 59: 305-12.
30. Geng, J.G., Bevilacqua, N.T., Moore, K.L. et al. Rapid neutrophil adhesion to activated endothelium mediated by GMP-140. Nature (Lond) 1990, 343: 757-60.
31. Davenpeck, K.L., Gauthier, T.W., Lefer, A.M. Inhibition of endothelial -derived nitric oxide promotes P-selectin expression and actions in the rat microcirculation. Gastroenterology 1994, 107: 1050-8.
32. McEver, R.P., Beckstead, J.H., Moore, K.L., Marshall-Carlson, L., Bainton, D.F. GMP-140, a platelet a-granule membrane protein, is also synthesized by vascular endothelial cells and is localized in Weibel-Palade bodies. J Clin Invest 1989, 84: 92-9.
33. Kubes, P., Suzuki, M., Granger, D,N. Nitric oxide: An endogenous modulator of leukocyte adhesion. Proc Natl Acad Sci USA 1991, 88: 4651-5.
34. Lefer, A.M., Lefer, D.J. Pharmacology of the endothelium in ischemia-reperfusion and circulatory shock. Annu Rev Pharmacol and Toxicol 1994, 33: 71-90.