Pharmacokinetic analysis of antiplatelet effect of sarpogrelate hydrochloride and its application to drug dosage regimen - Modeling based on reversible inhibition of 5-HT2 serotonergic receptor in the platelet membrane by sarpogrelate hydrochloride and its metabolite

Yakugaku Zasshi

Volumn 119, Issue 11, 1999, Pages 850-860

  Shimizu, Takako ^a   Yamada, Yasuhiko ^a   Tashita, Akiko ^a   Yamamoto, Koujirou ^a   Kotaki, Hajime ^b   Sawada, Yasufumi ^c   Iga, Tatsuji ^a  

^a UNIVERSITY OF TOKYO HOSPITAL   (Japan)

^b UNIVERSITY OF TOKYO   (Japan)

^c KYUSHU UNIVERSITY   (Japan)

Author keywords

5 HT2 receptor PK PD model; Active metabolite; Platelet aggregation; Sarpogrelate hydrochloride

Indexed keywords

ANTITHROMBOCYTIC AGENT; DRUG METABOLITE; SARPOGRELATE; SEROTONIN 2 RECEPTOR;

ARTICLE; CONTROLLED STUDY; DOSE CALCULATION; DOSE TIME EFFECT RELATION; DRUG BLOOD LEVEL; DRUG RECEPTOR BINDING; HUMAN; ORAL DRUG ADMINISTRATION; RECEPTOR BLOCKING; THROMBOCYTE AGGREGATION INHIBITION; THROMBOCYTE MEMBRANE;

EID: 0032749076     PISSN: 00316903     EISSN: None     Source Type: Journal    
DOI: 10.1248/yakushi1947.119.11_850     Document Type: Article

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