GLUT1-deficiency: Barbiturates potentiate haploinsufficiency in vitro

Pediatric Research

Volumn 46, Issue 6, 1999, Pages 677-683

  Klepper, Jörg ^a   Fischbarg, Jorge ^a   Vera, Juan Carlos ^b   Wang, Dong ^a   De Vivo, Darryl C ^a  

^a Och Spine at New York Presbyterian Hospitals   (United States)

^b MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GLUCOSE; GLUCOSE TRANSPORTER;

ADOLESCENT; ARTICLE; CASE REPORT; CELL MEMBRANE TRANSPORT; CHILD; ERYTHROCYTE MEMBRANE; FEMALE; GENE MUTATION; GLUCOSE TRANSPORT; HUMAN; MALE; PRESCHOOL CHILD; PRIORITY JOURNAL; PROTEIN DEFICIENCY; TRANSPORT KINETICS;

EID: 0032748870     PISSN: 00313998     EISSN: None     Source Type: Journal    
DOI: 10.1203/00006450-199912000-00006     Document Type: Article

References (37)

1. Pardridge WM, Boado RJ, Farrell CR 1990 Brain-type glucose transporter (Glut-1) is selectively localized to the blood-brain-barrier. J Biol Chem 265:18035-18040
2. Baldwin SA 1993 Mammalian passive glucose transporters: members of active and passive transport proteins [review]. Biochim Biophys Acta 1154:17-49
3. Bell IG, Burant CF, Takeda J, Gould GW 1993 Structure and function of mammalian facilitative sugar transporters [review]. J Biol Chem 268:19161-19164
4. Gould GW, Holman GD 1993 The glucose transporter family: structure, function and tissue-specific expression [review]. Biochem J 295:329-341
5. Seidner G, Garcia-Alvarez M, Yeh JI, O'Driscoll KR, Klepper J, Stump TS, Wang D, Spinner NB, Birnbaum MJ, De Vivo DC 1998 Glut-1 deficiency syndrome caused by haploinsufficiency of the blood-brain barrier hexose carrier. Nat Genet 18:1-4
6. De Vivo DC, Trifiletti RR, Jacobson RI, Ronen GM, Behmand RA, Harik SI 1991 Defective glucose transport across the blood-brain barrier as a cause of persistent hypoglycorrhachia, seizures, and developmental delay. N Engl J Med 325:703-709
7. De Vivo DC, Garcia-Alvarez M, Ronen G, Trifiletti R 1995 Glucose transport protein deficiency: an emerging syndrome with therapeutic implications. Int Pediatr 10:51-56
8. Klepper J, Wang D, Fischbarg J, Vera JC, Jarjour IT, O'Driscoll KR, De Vivo DC 1999 Defective glucose transport across brain tissue barriers: a newly recognized neurological syndrome. Neurochem Res 24:587-594
9. Honkanen RA, McBath H, Kushmerick C, Callender GE, Scarlata SF, Fenstermacher JD, Haspel HC 1995 Barbiturates inhibit hexose transport in cultured mammalian cells and human erythrocytes and interact directly with purified GLUT-1. Biochemistry 34:535-544
10. Gjedde A, Rasmussen M 1980 Pentobarbital anesthesia reduces blood-brain glucose transfer in the rat. J Neurochem 35:1382-1387
11. Ingwar M, Abdul-Rahman A, Siesjo BK 1980 Local cerebral glucose consumption in the artificially ventilated rat: influence of nitrous oxide analgesia and phenobarbital anesthesia. Acta Physiol Scand 109:177-185
12. Otsuka T, Wei L, Acuff VR, Shimizu A, Pettigrew KD, Patlak CS, Fenstermacher J 1991 Variation in local cerebral blood flow response to high-dose pentobarbital sodium in the rat. Am J Physiol 261:H110-H120
13. Otsuka T, Wei L, Bereczki D, Acuff VR, Patlak CS, Fenstermacher J 1991 Pentobarbital produces dissimilar changes in glucose influx and utilization in brain. Am J Physiol 261:R265-R275
14. Nilsson L, Seisjo BK 1975 The effect of phenobarbitone anesthesia on blood flow and oxygen consumption in the rat brain. Acta Anaesthesiol Scand 57:18-24
15. Saija A, Princi P, De Pasquale R, Costa G 1989 Modifications of the permeability of the blood-brain barrier and local cerebral metabolism in pentobarbital- and ketamine-anaesthetized rats. Neuropharmacology 28:997-1002
16. Todd MM, Warner DS 1992 A comfortable hypothesis reevaluated: cerebral metabolic depression and brain protection during ischemia. Anesthesiology 76:161-164
17. el-Barbary A, Fenstermacher JD, Haspel HC 1996 Barbiturate inhibition of GLUT-1 mediated hexose transport in human erythrocytes exhibits substrate dependence for equilibrium exchange but not unidirectional sugar flux. Biochemistry 35:15222-15227
18. Wei L, Otsuka T, Acuff V, Bereczki D, Pettigrew K, Patlak C, Fenstermacher JD 1993 The velocities of red cell and plasma flows through parenchymal microvessels of rat brain are decreased by pentobarbital. J Cereb Blood Flow Metab 13:487-497
19. Lowe AG, Walmsley AD 1986 The kinetics of glucose transport in human red blood cells. Biochim Biophys Acta 857:146-154
20. Naftalin RJ, Holman GD 1977 Transport of sugars in human red cells. In: Ellory JC, Lew VL (eds) Membrane Transport in Red Cells. Academic, New York, pp 257-300
21. Mueckler M, Caruso C, Baldwin SA, Panico M, Blench I, Morris HR, Allard WJ, Lienhard GE, Lodish HF 1985 Sequence and structure of a human glucose transporter. Science 228:941-945
22. Chugani HT, Phelps ME, Mazziotta JC 1978 Positron emission tomography study of human brain functional development. Ann Neurol 22:487-497
23. Clarke DD, Sokoloff L 1994 Circulation and energy metabolism of the brain. In: Siegel GJ (ed) Basic Neurochemistry: Molecular, Cellular and Medical Aspects, 5th Ed. Raven Press, New York, pp 645-748
24. Cremer JE 1982 Substrate utilization and brain development (review). J Cereb Blood Flow Metab 2:394-407
25. Dick APK, Harik SI, Klip A, Walker DM 1984 Identification and characterization of the glucose transporter of the blood/brain barrier by cytochalasin B binding and immunological reactivity. Proc Natl Acad Sci USA 81:7233-7237
26. Salah-Abu KM, Hampton KK, Findlay JBC 1982 The effects of general anesthetics on glucose and phosphate transport across the membrane of the human erythrocyte. Biochim Biophys Acta 688:163-168
27. Vannucci SJ, Maher F, Simpson IA 1997 Glucose transporter proteins in brain: delivery of glucose to neurons and glia [review]. Glia 21:2-21
28. Ito M, Miyaoka M, Ishii S 1984 Alterations in local cerebral glucose utilization during various anesthesia - the effect of urethane and a review. No To Shinkei 36:1191-1199
29. 14C]deoxy-glucose method of the measurement of local cerebral glucose utilization: theory, procedure, and normal values in the conscious and anesthetized rat. J Neurochem 29:897-916
30. Volpe JJ 1995 Neurology of the Newborn. WB Saunders Company, Philadelphia, p 195
31. Haslam RHA 1996 The nervous system. In: Behrman RE, Kliegman RM, Arvin AM (eds) Nelson Textbook of Pediatrics. Saunders, Philadelphia, p 1699
32. Anonymous 1996 The use of barbiturates in the control of intracranial hypertension. Brain Trauma Foundation [review]. J Neurotrauma 13:711-714
33. Shapiro HM 1975 Intracranial hypertension: therapeutic and anesthetic considerations. Anesthesiology 43:445-471
34. Willow M, Johnston GAR 1983 Pharmacology of barbiturates: electrophysiological and neurochemical studies. Int Rev Neurobiol 24:15-19
35. Nelson WE 1996 Nelson textbook of pediatrics. WB Saunders Company, Philadelphia, p 2057
36. Richter JA, Waller MB 1975 Effects of pentobarbital on acetylcholine content and release in different regions of rat brain. Biochem Pharmacol 26:609-615
37. Richter JA, Holtman JR Jr 1982 Barbiturates: their in vivo effects and potential biochemical mechanisms. Prog Neurobiol 18:275-319