Differential effects of psychostimulants and related agents on dopaminergic and serotonergic transporter function

European Journal of Pharmacology

Volumn 382, Issue 1, 1999, Pages 45-49

  Fleckenstein, Annette E ^a   Haughey, Heather M ^a   Metzger, Ryan R ^a   Kokoshka, Jerry M ^a   Riddle, Evan L ^a   Hanson, Jarom E ^a   Gibb, James W ^a   Hanson, Glen R ^a  

^a UNIVERSITY OF UTAH   (United States)

Author keywords

Amphetamine; Cocaine; Fenfluramine; Methylphenidate; Transporter

Indexed keywords

AMPHETAMINE; CATHINONE; COCAINE; DOPAMINE; DOPAMINE TRANSPORTER; FENFLURAMINE; METHAMPHETAMINE; METHCATHINONE; METHYLPHENIDATE; PSYCHOSTIMULANT AGENT; SEROTONIN; SEROTONIN TRANSPORTER;

ANIMAL CELL; ARTICLE; DOPAMINE UPTAKE; DOPAMINERGIC SYSTEM; DRUG ACTIVITY; DRUG EFFECT; NONHUMAN; PRIORITY JOURNAL; RAT; REGULATORY MECHANISM; SEROTONIN UPTAKE; SEROTONINERGIC SYSTEM; SYNAPTOSOME;

ANIMALS; CARRIER PROTEINS; DOPAMINE; DOPAMINE PLASMA MEMBRANE TRANSPORT PROTEINS; MALE; MEMBRANE GLYCOPROTEINS; MEMBRANE TRANSPORT PROTEINS; NERVE TISSUE PROTEINS; PSYCHOTROPIC DRUGS; RATS; RATS, SPRAGUE-DAWLEY; SEROTONIN; SEROTONIN PLASMA MEMBRANE TRANSPORT PROTEINS; SYNAPTOSOMES; VISUAL CORTEX;

EID: 0032748330     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-2999(99)00588-9     Document Type: Article

References (20)

1. Berman S.B., Zigmond M.J., Hastings T.G. Modification of dopamine transporter functions: effect of reactive oxygen species and dopamine. J. Neurochem. 67:1996;593-600.
2. Butcher S.P., Liptrot J., Aburthnott G.W. Characterization of methylphenidate and nomifensine induced dopamine release in rat striatum using in vivo brain microdialysis. Neurosci. Lett. 122:1991;245-248.
3. Copeland B.J., Vogelsberg V., Neff N.H., Hadjiconstantinou M. Protein kinase C activators decrease dopamine uptake into striatal synaptosomes. J. Pharmacol. Exp. Ther. 277:1996;1527-1532.
4. De Deurwaerdere P., Bonhomme N., Le Moal M., Spampinato U. D-Fenfluramine increases striatal extracellular dopamine in vivo independently of serotonergic terminals or dopamine uptake sites. J. Neurochem. 65:1995;1100-1108.
5. Fleckenstein A.E., Pogun S., Carroll F.I., Kuhar M.J. Recovery of dopamine transporter binding and function after intrastriatal administration of the irreversible inhibitor RTI-76 {3-beta-(3p-chlorophenyl)tropan-2-beta-carboxylic acid p-isothiocyantophenylethyl ester hydrochloride}. J. Pharmacol. Exp. Ther. 279:1996;200-206.
6. Fleckenstein A.E., Metzger R.R., Beyeler M.B., Gibb J.W., Hanson G.R. Oxygen radicals diminish dopamine transporter function in rat striatum. Eur. J. Pharmacol. 334:1997;111-114.
7. Fleckenstein A.E., Metzger R.R., Wilkins D.G., Gibb J.W., Hanson G.R. Rapid and reversible effects of methamphetamine on dopamine transporters. J. Pharmacol. Exp. Ther. 282:1997;834-838.
8. Graham D.G. Oxidative pathways for catecholamines in the genesis of neuromelanin and cytotoxic quinones. Mol. Pharmacol. 14:1978;633-643.
9. Hiramatsu M., Cho A.K. Enantiomeric differences in the effects of 3,4-methylenedioxymethampethamine on extracellular monoamines and metabolites in the striatum of freely-moving rats: an in vivo microdialysis study. Neuropharmacology. 29:1990;269-275.
10. Hurd Y.L., Ungerstedt U. In vivo neurochemical profile of dopamine uptake inhibitors and releasers in rat caudate-putamen. Eur. J. Pharmacol. 166:1989;251-260.
11. Kokoshka J.M., Metzger R.R., Wilkins D.G., Gibb J.W., Hanson G.R., Fleckenstein A.E. Methamphetamine treatment rapidly inhibits serotonin, but not glutamate, transporters in rat brain. Brain Res. 799:1998;78-83.
12. Kokoshka J.M., Vaughan R.A., Hanson G.R., Fleckenstein A.E. Nature of methamphetamine-induced rapid and reversible changes in dopamine transporters in rat brain. Eur. J. Pharmacol. 361:1998;269-275.
13. Kuczenski R., Segal D.S., Aizenstein M.L. Amphetamine, cocaine, and fencamfamine: relationship between locomotor and stereotypy response profiles and caudate and accumbens dopamine dynamics. J. Neurosci. 11:1991;2703-2712.
14. McPherson G.A. EBDA-Kinetic-Lowry. 1986;Elsevier-Biosoft, Cambridge, UK.
15. Melegra W.P., Williams A.E., Schmitz D.A., DiStefano E.W., Cho A.K. Pharmacokinetic and pharmacodynamic analysis of the actions of D-amphetamine and D-methamphetamine on the dopamine terminal. J. Pharmacol. Exp. Ther. 274:1995;90-96.
16. Metzger R.R., Hanson G.R., Gibb J.W., Fleckenstein A.E. Methylenedioxymethamphetamine-induced acute changes in dopamine transporter function. Eur. J. Pharmacol. 349:1998;205-210.
17. Metzger, R.R., Hanson, G.R., Gibb, J.W., Fleckenstein, A.E. 1998b. Multiple factors contribute to the methamphetamine-induced rapid decrease in striatal dopamine transporter function. 28th Annual Meeting, Soc. Neurosci., Abstract 580.4.
18. Stephans S.E., Yamamoto B.K. Methamphetamine-induced neurotoxicity: roles for glutamate and dopamine efflux. Synapse. 17:1994;203-209.
19. Vaughan R.A., Huff R.A., Uhl G.R., Kuhar M.J. Protein kinase C-mediated phosphorylation and functional regulation in striatal synaptosomes. Biol. Chem. 272:1997;15541-15546.
20. Wrona M.Z., Dryhurst G. Oxidation of serotonin by superoxide radical: implications to neurodegenerative brain disorders. Chem. Res. Toxicol. 11:1998;639-650.