Synthesis and aldose reductase inhibitory activities of novel dibenzocycloheptenone derivatives

European Journal of Medicinal Chemistry

Volumn 34, Issue 5, 1999, Pages 399-404

  Inoue, Jun ^a   Cui, Ying She ^a   Rodriguez, Libaniel ^b   Chen, Zhou ^b   Kador, Peter F ^b  

^a National Hospital Organization   (Japan)

^b NATIONAL EYE INSTITUTE   (United States)

Author keywords

Aldose reductase inhibitor; Diabetic complications; Dibenzocycloheptenone

Indexed keywords

ALDEHYDE REDUCTASE; ALDOSE REDUCTASE INHIBITOR; DIBENZO[A,D]CYCLOHEPTENE DERIVATIVE; SPIRO COMPOUND;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; DIABETIC RETINOPATHY; DRUG ACTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; NONHUMAN; RAT;

EID: 0032748147     PISSN: 02235234     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0223-5234(99)80089-0     Document Type: Article

References (18)

1. Kador P.F. Med. Res. Rev. 8:1988;325-352.
2. Dvornic D. Aldose Reductase Inhibition: An approach to the prevention of diabetic complications. 368:1987;McGrau Hill, New York.
3. Tomlinson D.R., Stevens E.J., Diemel L.T. Trends Pharmacol. Sci. 1994;293-297.
4. Kador P.F., Kinoshita J.H., Sharpless N.E. J. Med. Chem. 28:1985;841-849.
5. Kador P.F., Robinson W.G., Kinoshita J.H. Annu. Rev. Pharmacol. Toxicol. 25:1985;691-714.
6. Sima A.A.F., Bril V., Nathaniel T.A., McEwen J., Brown M.B., Lattimet S.A., Green D.A. N. Engl. J. M. 319:1988;548-555.
7. Mylary B.L., Larson E.R., Beyer T.A., Zembrowski W.J., Aldinger C.E., Dee M.F., Siegel T.W., Singleton D.H. J. Med. Chem. 34:1991;108-122.
8. Humber L.G. Ellis G.P, West G.B. Progress in Medicinal Chemistry. 24:1987;299-343 Elsevier Science Publishers, New York.
9. Sarges R. Adv. Drug Res. 18:1989;139-175.
10. Cerelli M.J., Curtis D.L., Dunn J.P., Nelson P.H., Peak T.M., Waterbury L.D. J. Med. Chem. 29:1986;2347-2351.
11. Kador P.F., Sharpless N.E. Mol. Pharmacol. 24:1983;521-531.
12. Humber L.G. US patent 3697581. 1972;7.
13. Ueda K., Tanaka S., Nomura K., Ono H. Jpn. Kokai Tokkyo Koho, JP 58124788. 1983;12.
14. Lee Y.S., Pearlstein R., Kador P.F. J. Med. Chem. 37:1994;787-792.
15. Herrmann R.K., Kador P.F., Kinoshita J.H. Exp. Eye. Res. 37:1983;467-474.
16. Old S.E., Sato S., Kador P.F., Carper D.A. Proc. Nat. Acad. Sci. USA. 87:1990;4942-4945.
17. Sato S., Old S., Carper D., Kador P.F. Adv. Exp. Med. Biol. 372:1995;259-268.
18. Sato S., Kador P.F. Biochem. Pharmacol. 40:1990;1033-1042.