IGF-I treatment increases motility and improves morphology of immature spermatozoa in the GH-deficient dwarf (dw/dw) rat

Growth Hormone and IGF Research

Volumn 9, Issue 4, 1999, Pages 236-240

  Vickers, M H ^a   Casey, P J ^a   Champion, Z J ^a   Gravance, C G ^a   Breier, B H ^a  

^a UNIVERSITY OF AUCKLAND   (New Zealand)

Author keywords

Insulin like growth factor I; Male fertility; Morphology; Motility; Spermatozoa

Indexed keywords

RECOMBINANT GROWTH HORMONE; SOMATOMEDIN C;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL STRUCTURE; CONTROLLED STUDY; GROWTH HORMONE BLOOD LEVEL; GROWTH HORMONE DEFICIENCY; MALE; MALE FERTILITY; MALE INFERTILITY; NONHUMAN; OSMOTIC MINIPUMP; PITUITARY DWARFISM; PRIORITY JOURNAL; RAT; SEMINAL VESICLE; SPERMATOZOON MOTILITY;

EID: 0032748123     PISSN: 10966374     EISSN: None     Source Type: Journal    
DOI: 10.1054/ghir.1999.0114     Document Type: Article

References (15)

1. Gravance C. G., Breier B. H., Vickers M. H., Casey P. J. Impaired semen characteristics in post pubertal growth hormone deficient dwarf (dw/dw) rats. Anim Reprod Sci. 49:1997;71-76.
2. Breier B. H., Vickers M. H., Gravance C. G., Casey P. J. Growth hormone (GH) therapy markedly increases the motility of spermatozoa and the concentration of insulin-like growth factor-I in seminal vesicle fluid in the male GH-deficient dwarf rat. Endocrinology. 137:1996;4061-4064.
3. Breier B. H., Vickers M. H., Gravance C. G., Casey P. Therapy with growth hormone: major prospects for the treatment of male subfertility? (Review) Endocr J. 45 (Suppl.):1998;S63-S60.
4. Ovesen P., Flyvbjerg A., Orskov H. Insulin-like growth factor I (IGF-I) and IGF binding proteins in seminal plasma before and after vasectomy in normal men. Fertil Steril. 63:1995;913-918.
5. Cailleau J., Vermeire S., Verhoeven G. Independent control of the production of insulin-like growth factor I and its binding protein by cultured testicular cells. Mol Cell Endocrinol. 69:1990;79-89.
6. Henricks D. M., Kouba A. J., Lackey B. R., Boone W. R., Gray S. L. Identification of insulinlike growth factor I in bovine seminal plasma and its receptor on spermatozoa: influence on sperm motility. Biol Reprod. 59:1998;330-337.
7. Butler A. A., Ambler G. R., Breier B. H., Roith D., Roberts C. T. Jr, Gluckman P. D. Growth hormone (GH) and insulin-like growth factor-I (IGF-I) treatment of the GH-deficient dwarf rat: differential effects on IGF-I transcription start site expression in hepatic and extrahepatic tissues and lack of effect on type I IGF receptor mRNA expression. Mol Cell Endocrinol. 101:1994;321-330.
8. Slott V. L., Linder R. E., Dyer C. J. Method of euthanasia does not effect sperm motility in the laboratory rat. Reprod Toxicol. 8:1994;371-374.
9. Slott V. L., Suarez J. D., Perrault S. D. Rat sperm motility analysis: Methodological considerations. Reprod Toxicol. 5:1991;449-458.
10. Miller R. J., Killian G. J. Morphometric analysis of the epididymis from normal and vasectomized rats. J Androl. 8:1987;279-291.
11. Miller, M. G. Jelks, K. B. Davis, R. O. Computerized analysis of rat sperm kinematics after administration of α-chlorohydrin: correlation of motility indices with sperm ATP levels. Proc 7th International Congress of Toxicology, Seattle, 1995 (abstract).
12. Wier P. J., Rumberger D. Isolation of rat sperm from the vas deferens for sperm motion analysis. Reprod Toxicol. 9:1995;327-330.
13. Blum W. F., Breier B. H. Radioimmunoassays for insulin-like growth factors and their binding proteins. Growth Regulation. 4 (Suppl.1):1994;11-19.
14. Glander H. J., Kratzsch J., Weisbrich C., Birkenmeier G. Insulin-like growth factor-I and alpha 2-macroglobulin in seminal plasma correlate with semen quality. Human Reprod. 11:1996;2454-2460.
15. Soder O., Bang P., Wahab A., Parvinen M. Insulin-like growth factors selectively stimulate spermatogonial, but not meiotic, deoxyribonucleic acid synthesis during rat spermatogenesis. Endocrinology. 131:1992;2344-2350.