Enhanced CEA production associated with aspirin in culture of CW-2 cells on some polymeric films

Cytotechnology

Volumn 31, Issue 3, 1999, Pages 233-242

  Higuchi, Akon ^a   Uchiyama, Shigeru ^a   Demura, Makoto ^b   Asakura, Tetsuo ^b   Cho, Chong Su ^c   Akaike, Toshihiro ^d   Takarada, Hirokazu ^a   Hara, Mariko ^a  

^a SEIKEI UNIVERSITY   (Japan)

^b TOKYO UNIVERSITY OF AGRICULTURE AND TECHNOLOGY   (Japan)

^c Chonnam National University   (South Korea)

^d TOKYO INSTITUTE OF TECHNOLOGY   (Japan)

Author keywords

Aspirin; Carcinoembryonic antigen; Cell culture; Enhanced production; Langmuir Blodgett film

Indexed keywords

ACETYLSALICYLIC ACID; CARCINOEMBRYONIC ANTIGEN; CARCINOMA CELL; CELL CULTURE; CELL DENSITY; CELL GROWTH; COPOLYMERIZATION; CULTURE MEDIUM; FILM; INOCULATION; MACROGOL; POLYMER; PROTEIN SYNTHESIS; SILK FIBROIN;

EID: 0032747862     PISSN: 09209069     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1008030730814     Document Type: Article

References (21)

1. Al-Rubeai M and Enery AW (1990) Mechanisms and kinetics of monoclonal antibody synthesis and secretion in synchronous and asynchronous hybridoma cell cultures. J. Biotechnol. 16: 67-86.
2. Cho CS, Kim SW and Komoto T (1990) Synthesis and structural study of an ABA block copolymer consisting of poly(γ-benzyl-L-glutamate) as the A block and poly(ethylene oxide) as the B block. Makromol. Chem. 191: 981.
3. Cho CS, Kobayashi A, Goto M, Park KH and Akaike T (1996) Difference in adhesion and proliferation of fibroblast between Langmuir-Blodgett films and cast surfaces of poly (γ-benzyl L-glutamate)/poly(ethylene oxide) diblock copolymer. J. Biomed. Mater. Res. 32: 425-432.
4. David GS, Reisfeld RA and Chino TH (1978) Continuous production of carcinoembryonic antigen in hollow fiber cell culture units: brief communication. J. Natl. Cancer Inst. 60: 303-306.
5. Fong W, Zhang Y and Yung (1997) Optimization of monoclonal antibody production: combined effects of potassium acetate and perfusion in a stirred tank bioreactor. Cytotechnology 24: 47-54.
6. Gentry A, Morse PA and Potter VR (1965) Pyridine metabolism in tissue culture cells derived from rat hepatomas. III. Relationship of thymidine to the metabolism of other pyrimidine nucleosides in suspension cultures derived from the Novikoff hepatoma. Cancer Res. 25: 517-525.
7. Higuchi A, Takarada H, Uchino J, Tanigaki Y and Hara M (1998) Hollow fiber bioreactor for high density and continuous production of carcinoembryonic antigen. Sen'i Gakkaishi 54: 301-308.
8. Kim YN, Park YS, Kim HK, Jeon BC, Youn SR and Lee HY (1993) Enhancement of the attachment on microcarriers and tPA production by fibroblast cells in a serum-free medium by the addition of the extracts of Centella asiatica. Cytotechnology 13: 221-226.
9. Lee GM, Kim SJ and Palsson BO (1994) Enhanced specific productivity of calcium alginate-entrapped hybridoma is cell line-specific. Cytotechnology 16: 1-15.
10. Mochizuki K, Sato S, Kato M and Hashizume S (1993) Enhanced production of human monoclonal antibodies by the use of fructose in serum-free hybridoma culture media, Cytotechnology 13:161-73.
11. Murakami F, Sasaki T and Sugahara T (1997) Lysozyme stimulates immunoglobulin production by human-human hybridoma and human peripheral blood lymphocytes. Cytotechnology 24: 177-182.
12. Quarles JM, Morris NG and Leibovitz A (1980) Carcinoembryonic antigen production by human colorectal adenocarcinoma cells in matrix-perfusion culture. In vitro 16: 113-118.
13. Rutzky LP, Tomita JT, Calenoff MA and Kahan BD (1979) Human colon adenocarcinoma cells. III. In vitro organoid expression and carcinoembryonic antigen kinetics in hollow fiber culture. J. Natl. Cancer Inst. 63: 893-902.
14. Somenshein GE and Brawerman G (1976) Differential translation of mouse myeloma messenger RNAs in a wheat germ cell-free system. Biochemistry 15: 5501-5506.
15. Sugahara T, Shirahata S, Yamada K and Murakami H (1991) Purification of immunoglobulin production stimulating factor-IIα derived from Namalwa cells. Cytotechnology 5: 255-263.
16. Suzuki E and Ollis DF (1990) Enhanced antibody production at slowed growth rates: Experimental demonstration and a structured model. Biotechnol. Prog. 6: 231-236.
17. Suzuki E, Terada S, Ueda H, Fujita T, Komatsu T, Takayama S and Reed JC (1997) Establishing apoptosis resistant cell lines for improving protein productivity of cell culture. Cytotechnology 23: 55-59.
18. Takahashi K, Tereda S, Ueda H, Makishima F and Suzuki E (1994) Growth rate suppression of cultured mammalian cells enhances protein productivity. Cytotechnology 15: 57-64.
19. Toyoda K, Sugahara T, Inoue K, Yamada K, Shirahata S and Murakami H (1990) Purification and characterization of the immunoglobulin production stimulating factor derived from human B lymphoblastoid cell HO-323. Cytotechnology 3: 189-197.
20. Wakuri S, Izumi J, Sasaki K, Tanaka N and Ono H (1993) Cytotoxicity study of MEIC chemicals by colony formation and ATP assays. Toxic in Vitro 7: 517-521.
21. Yamaguchi M, Shirai Y, Inouye Y, Shoji M, Kamei M, Hashizume S and Shirahata S (1997) Changes in monoclonal antibody productivity of recombinant BHK cells immobilized in collagen gel particles. Cytotechnology 23: 5-12.