Orphenadrine poisoning in a child: Clinical and analytical data

Intensive Care Medicine

Volumn 25, Issue 10, 1999, Pages 1134-1136

  Van Herreweghe, I ^a   Mertens, K ^a   Maes, V ^a   Ramet, J ^a  

^a UNIVERSITY HOSPITAL BRUSSELS   (Belgium)

Author keywords

Intoxication; Orphenadrine intoxication; Physostigmine

Indexed keywords

ACTIVATED CARBON; ANTICONVULSIVE AGENT; CEFUROXIME; CLONAZEPAM; DIAZEPAM; DRUG METABOLITE; LIDOCAINE; ORPHENADRINE; PHENYTOIN; PHYSOSTIGMINE;

AGITATION; ARTICLE; ARTIFICIAL VENTILATION; ATAXIA; CASE REPORT; CLONIC SEIZURE; CONFUSION; DRUG BLOOD LEVEL; DRUG HALF LIFE; DRUG INTOXICATION; ENDOTRACHEAL INTUBATION; FEMALE; HEART VENTRICLE TACHYCARDIA; HUMAN; INTRAMUSCULAR DRUG ADMINISTRATION; INTRAVENOUS DRUG ADMINISTRATION; NEUROLOGIC DISEASE; PRESCHOOL CHILD; RECTAL DRUG ADMINISTRATION; TONIC SEIZURE; TREATMENT OUTCOME;

AKATHISIA, DRUG-INDUCED; ANTI-ARRHYTHMIA AGENTS; ANTICONVULSANTS; ANTIPARKINSON AGENTS; ATAXIA; CHILD, PRESCHOOL; CHOLINESTERASE INHIBITORS; DIAZEPAM; DRUG MONITORING; EPILEPSY, TONIC-CLONIC; FEMALE; HUMANS; INTENSIVE CARE; LIDOCAINE; MUSCARINIC ANTAGONISTS; ORPHENADRINE; PHYSOSTIGMINE; RESPIRATION, ARTIFICIAL; TACHYCARDIA, VENTRICULAR;

EID: 0032747684     PISSN: 03424642     EISSN: None     Source Type: Journal    
DOI: 10.1007/s001340051024     Document Type: Article

References (12)

1. 1. Dollery C (1991) Orphenadrine hydrochloride. In: Dollery C (ed) Therapeutic drugs, vol 2. Churchill-Livingstone, Edinburgh. pp 34-38
2. 2. Elmalem J, Garnier R, Nguyen-Huu-Chieu R, Bismuth Ch, Efthymiou M (1985) Intoxication aiguë par l'orphénadrine. Ann Med Interne 136: 640-645
3. 3. Kulig K (1992) Anticholinergic poisoning. In: Poisindex toxicologic management, vol 73. Micromedex, Denver
4. 4. Danze LK, Langdorf MI (1991). Reversal of orphenadrine-induced ventricular tachycardia with physostigmine. J Emerg Med 9: 453-457
5. 5. Ellenhorn MJ (1997) Muscle relaxants: orphenadrine. In: Ellenhorn MJ (ed) Matthew J Ellenhorn's medical toxicology. Diagnosis and treatment of human poisoning. Williams and Wilkins, Baltimore, pp 948-952
6. 6. Mills KC (1993) Essential emergency medicine pharmacokinetics: prevention of iatrogenic poisoning. Top Emerg Med 15: 18-29
7. 7. Sangster B, van Heijst A, Zimmerman A (1977) Treatment of orphenadrine overdose. N Engl J Med 296: 1006
8. 8. Zandberg P, Sangster B (1982) The influence of physostigmine on respiratory and circulatory changes caused by overdose of orphenadrine or imipramine in the rat. Acta Pharmacol Toxicol 50: 185-195
9. 9. Clark RF (1993) Orphenadrine poisoning and review of physostigmine. J Emerg Med 11: 97
10. 10. Slovis T, Ott J, Teitelbaum T, Lipscomb W (1971) Physostigmine therapy in acute tricyclic antidepressant poisoning. Clin Toxicol 4: 451-459
11. 11. Snyder B, Kane M, Plocher D (1976) Orphenadrine overdose treated with physostigmine. N Engl J Med 295: 1435
12. 12. Clarke B, Mair J, Rudolf M (1985) Acute poisoning with Orphenadrine. Lancet I: 1386