Enzymatic degradation of leuprolide in rat intestinal mucosal homogenates

Pharmaceutical Development and Technology

Volumn 4, Issue 4, 1999, Pages 539-544

  Zheng, Yuqun ^a   FuLu, Mou Ying ^a   Qiu, Yihong ^a   Reiland, Thomas L ^a  

^a ABBOTT LABORATORIES   (United States)

Author keywords

Abbott 43818; Emulsion; Enzymatic degradation; Intestinal mucosa; Leuprolide acetate; Peptide; Protease inhibitor

Indexed keywords

3,4 DICHLOROISOCOUMARIN; ALPHA 2 MACROGLOBULIN; ANTIPAIN; BESTATIN; HYDROXYMERCURIBENZOIC ACID; LEUPRORELIN; PROTEINASE INHIBITOR; SERINE PROTEINASE;

ANIMAL TISSUE; ARTICLE; CHEMICAL REACTION KINETICS; CONTROLLED STUDY; DRUG DEGRADATION; DRUG FORMULATION; EMULSION; INTESTINE MUCOSA; MALE; MICHAELIS CONSTANT; NONHUMAN; PRIORITY JOURNAL; RAT; REACTION ANALYSIS; REACTION TIME;

ANIMALS; ANTINEOPLASTIC AGENTS, HORMONAL; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; HALF-LIFE; HYDROLYSIS; INTESTINAL MUCOSA; INTESTINE, SMALL; KINETICS; LEUPROLIDE; MALE; PROTEASE INHIBITORS; RATS; RATS, SPRAGUE-DAWLEY;

EID: 0032747324     PISSN: 10837450     EISSN: None     Source Type: Journal    
DOI: 10.1081/PDT-100101392     Document Type: Article

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