An integrated pharmacokinetic and pharmacodynamic study of arsenite action. 1. Heme oxygenase induction in rats

Teratogenesis Carcinogenesis and Mutagenesis

Volumn 19, Issue 6, 1999, Pages 385-402

  Kitchin, Kirk T ^a   Del Razo, Luz Maria ^b   Brown, Janice L ^a   Anderson, Willard L ^a   Kenyon, Elaina M ^a  

^a U S ENVIRONMENTAL PROTECTION AGENCY   (United States)

^b DEPARTAMENTO DE FÍSICA   (Mexico)

Author keywords

Arsenic; Arsenite; Dimethylarsinic acid; Enzyme induction; Heme oxygenase; Monomethylarsonic acid; Pharmacodynamics; Pharmacokinetics

Indexed keywords

ARSENIC ACID; ARSENIC TRIOXIDE; CACODYLIC ACID; HEME OXYGENASE; METHANEARSONIC ACID;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; DOSE RESPONSE; DOSE TIME EFFECT RELATION; ENZYME ACTIVITY; ENZYME INDUCTION; FEMALE; NONHUMAN; PHARMACODYNAMICS; PRIORITY JOURNAL; RAT;

ADMINISTRATION, ORAL; ANIMALS; ARSENIC; ARSENITES; BIOTRANSFORMATION; CACODYLIC ACID; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME INDUCTION; FEMALE; HEME OXYGENASE (DECYCLIZING); KIDNEY; KINETICS; LIVER; MODELS, BIOLOGICAL; RATS; RATS, SPRAGUE-DAWLEY; TERATOGENS; TISSUE DISTRIBUTION;

ANIMALIA;

EID: 0032746684     PISSN: 02703211     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1520-6866(1999)19:6<385::AID-TCM3>3.0.CO;2-V     Document Type: Article

References (24)

1. Tseng WP, Chu HM, How SW, Fong JM, Lin CS, Yeh S. Prevalence of skin cancer in an endemic area of chronic arsenicism in Taiwan. J Natl Cancer Inst 1968;40:453-463.
2. Smith AH, Goycolea M, Haque R, Biggs ML. Marked increase in bladder and lung cancer mortality in a region of northern Chile due to arsenic in drinking water. Am J Epidemiol 1998;147:660-669.
3. Vahter M. Species differences in the metabolism of arsenic compounds. Applied Organometal Chem 1994;8:175-182.
4. E.A. Crecelius EA, Bloom NS, Cowan CE, Jenne EA. Determination of arsenic species in limnological samples by hydride generation atomic absorption spectroscopy. In: Electric Power Research Institute, editor. Speciation of selenium and arsenic in natural waters and sediments. Vol 2: Arsenic speciation. Palo Alto, California, EA-4641. Project 2020-2; 1986. p 1-28.
5. D. Cox. Arsine evolution-electrothermal atomic absorption method for the determination of nanogram levels of total arsenic in urine and water. J Anal Toxicol 1980;4:207-211.
6. Tenhunen R, Marver H, Schmid R. Microsomal heme oxygenase: characterization of the enzyme. J Biol Chem 1969;244:6388-6394.
7. Maines M, Ibrahim N, Kappas A. Solubilization and partial purification of heme oxygenase from rat liver. J Biol Chem 1977;252:5900-5903.
8. Sunderman W. Metal induction of heme oxygenase. Ann NY Acad Sci 1987;514:65-80.
9. Elbirt KK, Whitmarsh AJ, Davis RJ, Bonkovsky HL. Mechanism of sodium arsenite-mediated induction of heme oxygenase-1 in hepatoma cells. J Biol Chem 1998;273:8922-8931.
10. Kitchin, KT. Regulation of rat hepatic delta-aminolevulinic acid synthetase and heme oxygenase activities: Evidence for control by heme and against mediation by prosthetic iron. Int J Biochem 1983;15:479-485.
11. Taketani S, Kohno H, Yoshinaga T, Tokunaga R. Induction of heme oxygenase in rat hepatoma cells by exposure to heavy metals and hyperthermia. Biochem Int 1988;17:665-672.
12. Maines MD. Heme oxygenase: function, multiplicity, regulatory mechanisms and clinical applications. FASEB J 1988;2:2557-2568.
13. Maines MD. The heme oxygenase system: a regulator of second messenger gases. Annu Rev Pharmacol Toxicol 1997;37:517-554.
14. Muller RM, Taguchi H, Shibahara S. Nucleotide sequence and organization of the rat heme oxygenase gene. J Biol Chem 1987;14:6795-6802.
15. Shibahara S, Sato M, Muller RM, Yosida T. Structural organization of the human heme oxygenase gene and the function of its promoter. Eur J Biochem 1989;179:557-563.
16. Tully DB, Collins BJ, Smith CS, Murnatz MM, Chapin RE. New biomarkers of toxicity for four high priority heavy metal pollutants. Fed Am Soc Exp Biol 1999;13:Abstract No. 442.
17. Choi AMK, Alam J. Heme oxygenase-1: Function, regulation, and implication of a novel stress-inducible protein in oxidant-induced lung injury. Am J Resp Cell Molec Biol 1996;15:9-19.
18. Eaton DL, Stacey NH, Wong K, Klaassen CD. Dose-response effects of various metal ions on rat liver metallothionein, glutathione heme oxygenase and cytochrome P-450. Toxicol Applied Pharmacol 1980;55:393-402.
19. Menzel DB, Rasmussen RE, Lee E, Meacher DM, Said B, Hamadeh H, Vargas M, Green H, Roth RN. Human lymphocyte heme oxygenase 1 as a response biomarker to inorganic arsenic. Biochem Biophys Res Commun 1998;250:653-656.
20. Nowell SA, Leakely JEA, Warren JF, Lang NP, Frame LT. Identification of enzymes responsible for the metabolism of heme in human platelets. J Biol Chem 1998;273:33342-33346.
21. Kenyon EM, Del Razo LM, Brown JL, Anderson WA, Hughes MF, Kitchin KT. Metabolism and disposition of arsenite (AsIII) and its relationship to heme oxygenase (HO) induction in mice. Toxicologist, 1999;48, No 1-S, Abstract No. 1046.
22. Smith AH, Hopenhayn-Rich C, Bates MN, Goeden HM, Hertz-Picciotto I, Duggan HM, Wood R, Kosnett MJ, Smith MT. Cancer risks from arsenic in drinking water. Environ Health Perspec 1992;97:259-267.
23. Styblo M, Delnomdedieu M, Thomas DJ. Mono-and dimethylation of arsenic in rat liver cytosol in vitro. Chem Biol Interact 1996;99:147-164.
24. Styblo M, Del Razo LM, Thomas DJ. Metabolism and toxicity of arsenicals in primary rat hepatocytes. Toxicologist 1999;48, No. 1-S, Abstract No. 1652.