Structure - Immunosuppressive activity relationships of new analogues of 15-deoxyspergualin. 2. Structural modifications of the spermidine moiety

Journal of Medicinal Chemistry

Volumn 42, Issue 23, 1999, Pages 4749-4763

  Lebreton, Luc ^a   Jost, Eric ^b   Carboni, Bertrand ^b   Annat, Jocelyne ^a   Vaultier, Michel ^b   Dutartre, Patrick ^a   Renaut, Patrice ^a  

^a Laboratoires Fournier SA   (France)

^b Chimie et Photonique Moleculaires Rennes   (France)

Author keywords

[No Author keywords available]

Indexed keywords

15 DEOXYSPERGUALIN DERIVATIVE; [4 [(3 AMINO 3 PHENYLPROPYL)AMINO]BUTYL]CARBAMIC ACID 2 [[6 (AMINOIMINOMETHYL)AMINO]HEXYL]AMINO 2 OXOETHYL ESTER; [4 [(3 AMINOBUTYL)AMINO]BUTYL]CARBAMIC ACID 2 [[6 [(AMINOIMINOMETHYL)AMINO]HEXYL]AMINO] 2 OXOETHYL ESTER; CYCLOPHOSPHAMIDE; IMMUNOSUPPRESSIVE AGENT; LF 08 0299; N1 [4 [(3 AMINOBUTYL)AMINO]BUTYL] N3 [6 [(AMINOIMINOMETHYL)AMINO]HEXYL]PROPANEDIAMIDE; SPERGUALIN DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; GRAFT VERSUS HOST REACTION; IMMUNOSUPPRESSIVE TREATMENT; INTRAPERITONEAL DRUG ADMINISTRATION; MOUSE; NONHUMAN; STRUCTURE ACTIVITY RELATION; SURVIVAL TIME; TREATMENT OUTCOME;

ANIMALS; CARBAMATES; DRUG EVALUATION, PRECLINICAL; GRAFT VS HOST DISEASE; GUANIDINES; HEART TRANSPLANTATION; IMMUNOSUPPRESSIVE AGENTS; MICE; RATS; RATS, INBRED LEW; SPERMIDINE; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; TRANSPLANTATION, HOMOLOGOUS;

EID: 0032744861     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm991043x     Document Type: Article

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