Mixed polymer coating for modified release from coated spheroids

Pharmaceutical Development and Technology

Volumn 4, Issue 4, 1999, Pages 561-570

  Tan, Yvonne T F ^a   Heng, Paul W S ^b   Wan, Lucy S C ^b  

^a SCHOOL OF PHARMACEUTICAL SCIENCES   (Malaysia)

^b NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

Author keywords

Drug release kinetics; Hydroxypropylmethylcellulose; Mixed polymer coating; Modified release; Sodium carboxymethylcellulose; Spheroid

Indexed keywords

CARBOXYMETHYLCELLULOSE; CEKOL 700; HYDROXYPROPYLMETHYLCELLULOSE; MACROGOL 400; METOLOSE 60 SH; PLASDONE C15; POLYMER; POVIDONE; UNCLASSIFIED DRUG; WATER;

ARTICLE; CHEMICAL COMPOSITION; DELAYED DRUG RELEASE; DRUG COATING; DRUG POTENTIATION; DRUG SOLUBILITY; HALF LIFE TIME; PH; PRIORITY JOURNAL; TRANSPORT KINETICS; VISCOSITY;

CARBOXYMETHYLCELLULOSE; DRUG COMPOUNDING; HYDROGEN-ION CONCENTRATION; LACTOSE; METHYLCELLULOSE; MICROSCOPY, ELECTRON, SCANNING; MICROSPHERES; OXAZINES; PARTICLE SIZE; PHARMACEUTIC AIDS; POLYETHYLENE GLYCOLS; POVIDONE; SOLUBILITY; VEHICLES;

EID: 0032743297     PISSN: 10837450     EISSN: None     Source Type: Journal    
DOI: 10.1081/PDT-100101395     Document Type: Article

References (16)

1. G. Maffione, P. Iamartino, G. Guglielmini, and A. Gazzaniga, High-viscosity HPMC as a film-coating agent, Drug Dev. Ind. Pharm., 19, 2043-2053 (1993).
2. A. Gazzaniga, P. Iamartino, G. Maffione, and M. E. Sangalli, Oral delayed-release system for colonic specific delivery, Int. J. Pharm., 108, 77-83 (1994).
3. M. R. Harris and I. Ghebre-Sellassie, Aqueous polymeric coating for modified-release pellets, in Aqueous Polymeric Coatings for Pharmaceutical Dosage Forms (J. M. McGinity, ed.), Marcel Dekker, New York, 1989, pp. 63-79.
4. T. Nagai, F. Sekigawa, and N. Hoshi, Applications of HPMC and HPMCAS aqueous film coating of pharmaceutical dosage forms, in Aqueous Polymeric Coatings for Pharmaceutical Dosage Forms (J. M. McGinity, ed.), Marcel Dekker, New York, 1989, pp. 81-152.
5. P. W. S. Heng, L. S. C. Wan, and Y. T. F. Tan, Optimization of spheroid production by centrifugal rotary processing, Int. J. Pharm., 143, 107-112 (1996).
6. L. S. C. Wan, P. W. S. Heng, and Y. T. F. Tan, Influence of hydroxypropylmethyl cellulose and sodium carboxymethyl cellulose as coating polymers on drug release from spheroids, S.T.P. Pharma Sci., 5, 128-133 (1995).
7. L. S. C. Wan, P. W. S. Heng, and Y. T. F. Tan, Drug release from spheroids coated with a mixture of HPMC-NaCMC, Chin. Pharm. J., 46, 491-504 (1994).
8. C. V. Walker and J. I. Wells, Rheological synergism between ionic and non-ionic cellulose gums, Int. J. Pharm., 11, 309-322 (1982).
9. S. C. Porter and I. Ghebre-Sellassie, Key factors in the development of modified-release pellets, in Multiparticulate Oral Drug Delivery (I. Ghebre-Sellassie, ed.), Marcel Dekker, New York, 1992, pp. 1-28.
10. L. C. Feely and S. S. Davis, Influence of surfactants on drug release from hydroxypropyl methylcellulose matrices, Int. J. Pharm., 41, 83-90 (1988).
11. D. A. Alderman, A review of cellulose ethers in hydrophilic matrices for oral controlled release dosage forms, Int. J. Pharm. Technol. Prod. Manuf., 5, 1-9 (1984).
12. K. Mitchell, J. L. Ford, D. J. Armstrong, P. N. C. Elliott, and C. Rostron, The effect of electrolytes and drugs on the cloud point of hydroxypropylmethylcellulose gels and the dissolution of drugs from hydroxypropylmethylcellulose matrix tablets, in Pharmaceutical Techonology Controlled Drug Release, Vol. 2 (J. I. Well and M. H. Rubinstein eds.), Ellis Horwood, New York, 1991, pp. 23-33.
13. R. Laakso, Release of indomethacin impregnated with polysorbate 80 from tablets and hard gelatin capsules, Acta Pharm. Fenn., 93, 119-127 (1984).
14. R. Laakso, E. Kristoffersson, and M. Marvola, Bi-exponential first-order release kinetics of indomethacin from tablets containing polysorbate 80, Int. J. Pharm., 19, 35-42 (1984).
15. S. Malamataris and A. Avgerinos, Controlled release indomethacin microspheres prepared by using an emulsion solvent-diffusion technique, Int. J. Pharm., 62, 105-111 (1990).
16. D.M. Bates and D. G. Watts, Nonlinear Regression Analysis and Its Applications, John Wiley & Sons, New York, 1988.