Prevention by carp extract of myelotoxicity and gastrointestinal toxicity induced by 5-fluorouracil without loss of antitumor activity in mice

Journal of Ethnopharmacology

Volumn 68, Issue 1-3, 1999, Pages 39-45

  Kimura, Yoshiyuki ^a   Okuda, Hiromichi ^a  

^a EHIME UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

5 Fluorouracil; Antitumor effects; Carp (Cyprinus carpio L.); Prevention of side effects

Indexed keywords

FLUOROURACIL;

AMINO ACID ANALYSIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; ARTICLE; BONE MARROW TOXICITY; CARP; CONTROLLED STUDY; GASTROINTESTINAL TOXICITY; LEUKOCYTE COUNT; MALE; MOUSE; NONHUMAN; SARCOMA; SMALL INTESTINE;

AMINO ACIDS; ANIMALS; ANTIMETABOLITES, ANTINEOPLASTIC; BONE MARROW DISEASES; CARPS; FATTY ACIDS; FLUOROURACIL; GASTROINTESTINAL DISEASES; LEUKOCYTE COUNT; LIVER DISEASES; MALE; MICE; MICE, INBRED ICR; SARCOMA, EXPERIMENTAL; TISSUE EXTRACTS;

EID: 0032742597     PISSN: 03788741     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-8741(99)00126-9     Document Type: Article

References (17)

1. Burns C.P., North J.A. Adriamycin transport and sensitivity in fatty acid-modified leukemia cells. Biochimica et Biophysica Acta. 888:1986;10-17.
2. Burns C.P., Luttengger D.G., Dudley D.T., Buettmer G.R., Spector A.A. Effect of modification of plasma membrane fatty acid composition of fluidity and methotrexate transport in L1210 murine leukemia cells. Cancer Research. 39:1979;1726-1736.
3. Burns C.P., Haugstad B.N., Mossman C.J., North J.A., Ingraham L.H. Membrane lipid alteration: effect on cellular uptake of mitoxanthrone. Lipids. 23:1988;393-397.
4. Caballero G.A., Ausma R.K., Quebbema E.J. Long-term, ambulatory, continuous infusion of 5-FU for the treatment of advanced adenocarcinomas. Cancer Treatment Report. 69:1985;13-15.
5. Duschinsky R., Pleven E., Heidelberger C. The synthesis of sefluoropyrimidines. Journal American Chemical Society. 79:1957;4559-4560.
6. Guffy M.M., North J.A., Burns C.P. Effect of cellular fatty acid alteration on adriamycin sensitivity in cultured L1210 murine leukemia cells. Cancer Research. 44:1984;1863-1866.
7. Heidelberger C., Ansfield F.J. Experimental and clinical use of fluorinated pyrimidines in cancer chemotherapy. Cancer Research. 23:1963;1226-1243.
8. Houghton J.A., Houghton P.J., Wooten R.S. Mechanism of induction of gastrointestinal toxicity in the mouse by 5-fluorouracil, 5-fluorouridine and 5-fluoro-2′-deoxyuridine. Cancer Research. 39:1979;2406-2413.
9. Kimura Y., Okuda H., Arichi H. Effects of geniposide isolated from Gardenia jasminoides on metabolic alterations in high sugar diet-fed rats. Chemical Pharmaceutical Bulletin. 30:1982;4444-4447.
10. Kimura Y., Okuda H., Arichi S. Effects of non-sugar fraction in black sugar on lipid and carbohydrate metabolism; part I. Planta Medica. 50:1984;465-468.
11. Nelson G.J., Kelly D.S., Hunt J.E. Effect on nutritional status on the fatty acid composition of rat liver and cultured hepatocytes. Lipids. 21:1986;454-459.
12. Schuetz J.D., Wallance H.J., Diasio R.B. 5-Fluorouracil incorporation into DNA of CF-1 mouse bone marrow cells as a possible mechanism of toxicity. Cancer Research. 44:1984;1358-1363.
13. Seifert P., Baker H.L., Reed M.L. Comparison of continuously infused 5-fluorouracil with bolus injection in treatment of patients with colorectal adenocarcinoma. Cancer. 36:1975;123-128.
14. Shah A., MacDonald W., Goldie J., Gudauskas G., Brisebois B. 5-FU infusion in advanced colorectal cancer: comparison of three dose schedules. Cancer Treatment Report. 69:1985;739-742.
15. Spector A.A., Burns C.P. Biological and therapeutic potential of membrane lipid modification in tumors. Cancer Research. 47:1987;4529-4537.
16. Stillwell W., Ehringer W., Jenski L.J. Docosahexaenoic acid increases permeability of lipid vesicles and tumor cells. Lipids. 28:1993;103-108.
17. Yoo, T.-J., Kuo, C.-Y., Spector, A.A., Denning, G.M., Floyd, R., Whiteaker, S., Kim, H., Kim, J., Abba, M., Budd, T.W., 1982. Effect of fatty acid modification of cultured hepatoma cells on susceptibility to natural killer cells. Cancer Research 42, 3596-3600.