The preparation of soft gelatin capsules for a radioactive tracer study

Pharmaceutical Development and Technology

Volumn 4, Issue 4, 1999, Pages 507-513

  Tesconi, Marc S ^a   Bramer, Steven L ^b   Yalkowsky, Samuel H ^a  

^a UNIVERSITY OF ARIZONA   (United States)

^b Otsuka America Pharmaceutical   (United States)

Author keywords

Dissolution testing; Physicochemical characterization; Radioactive tracer; Soft gelatin capsule

Indexed keywords

7 CHLORO 5 HYDROXY 1 [2 METHYL 4 (2 METHYLBENZOYLAMINO)BENZOYL] 2,3,4,5 TETRAHYDRO 1H BENZAPINE; CARBON 14; GELATIN; MACROGOL; NEW DRUG; POLYMER; POLYSORBATE 80; RADIOISOTOPE; TOLVAPTAN; UNCLASSIFIED DRUG;

ARTICLE; CRYSTALLIZATION; DISSOLUTION; DRUG STRUCTURE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; ISOTOPE LABELING; POWDER; PRIORITY JOURNAL; THERMAL ANALYSIS;

BENZAZEPINES; CAPSULES; CHEMISTRY, PHYSICAL; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; EXCIPIENTS; GELATIN; PARTICLE SIZE; POWDERS; RADIOPHARMACEUTICALS; SOLUBILITY; THERMOGRAVIMETRY;

EID: 0032742468     PISSN: 10837450     EISSN: None     Source Type: Journal    
DOI: 10.1081/PDT-100101388     Document Type: Article

References (6)

1. C. W. Sheppard, Basic Principles of the Tracer Method, John Wiley and Sons, New York, 1968.
2. H. M. Abdou, Dissolution, Bioavailability, and Bioequivalence, Mack Publishing Co., Easton, PA, 1989, pp. 53-66.
3. E. T. Cole, Liquid filled hard-gelatin capsules, Pharm. Technol. Int., Sept., 28-33 (1989).
4. S. Nema, R. J. Washkuhn, and R. J. Brendel, Excipients and their use in injectable products, P.D.A. J. Pharm. Sci. Technol., 51, 166-171 (1997).
5. A. J. Weiss, E. L. Mancall, J. A. Koltes, J. C. White, and L. G. Jackson, Dimethylacetamide: A hitherto unrecognized hallucinogenic agent, Science, 136, 151-152 (1962).
6. A. J. Weiss, L. G. Jackson, R. A. Carabasi, E. L. Mancall, and J. C. White, A phase I study of dimethylacetamide, Cancer Chemother. Rep., 16, 477-486 (1962).