A mutation in the glycine binding pocket of the N-methyl-D-aspartate receptor NR1 subunit alters agonist efficacy

Molecular Brain Research

Volumn 73, Issue 1-2, 1999, Pages 189-192

  Wood, Michael W ^a   Vandongen, Hendrika M A ^a   Vandongen, Antonius M J ^a  

^a DUKE UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

Affinity; DCK; Efficacy; HA 966; NMDA receptor; Pharmacology

Indexed keywords

3 AMINO 1 HYDROXY 2 PYRROLIDINONE; GLYCINE; KYNURENIC ACID; N METHYL DEXTRO ASPARTIC ACID RECEPTOR STIMULATING AGENT;

AMINO ACID ANALYSIS; ARTICLE; BINDING AFFINITY; DRUG EFFICACY; LIGAND BINDING; MUTATION; PRIORITY JOURNAL;

ANIMALS; BINDING SITES; BINDING, COMPETITIVE; DOSE-RESPONSE RELATIONSHIP, DRUG; EXCITATORY AMINO ACID AGONISTS; EXCITATORY AMINO ACID ANTAGONISTS; FEMALE; GLYCINE; KYNURENIC ACID; MICE; MUTATION; OOCYTES; PYRROLIDINONES; RECEPTORS, N-METHYL-D-ASPARTATE; XENOPUS LAEVIS;

EID: 0032742314     PISSN: 0169328X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0169-328X(99)00247-8     Document Type: Article

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