Disorder, molecular mobility, and solid-state kinetics: The two- environment model

Journal of Pharmaceutical Sciences

Volumn 88, Issue 11, 1999, Pages 1234-1236

  Skwierczynski, Raymond D ^a  

^a 3M COMPANY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ASPARTAME;

ARTICLE; CALCULATION; KINETICS; MATHEMATICAL ANALYSIS; MOLECULAR MODEL; REACTION ANALYSIS; SOLID STATE;

EID: 0032742303     PISSN: 00223549     EISSN: None     Source Type: Journal    
DOI: 10.1021/js980354c     Document Type: Article

References (14)

1. Leeson, L. J.; Mattocks, A. M. Decomposition of Aspirin in the Solid State. J. Am. Pharm. Assoc. Sci. Ed. 1958, 47, 329-333.
2. Bawn, C. E. H. In Chemistry of the Solid State; Garner, W. E., Ed.; Butterworth Scientific: London, 1955; pp 254-267.
3. Carstensen, J. T. Solid Pharmaceutics Mechanical Properties and Rate Phenomena; Academic: New York, 1980, Chapter 6.
4. Byrn, S. R. Solid-state Chemistry of Drugs; Academic: New York, 1980.
5. Skwierczynski, R. D.; Connors, K. A. Demethylation Kinetics of Aspartame and L-Phenylalanine Methyl Ester in Aqueous Solution. Pharm. Res. 1993, 10, 1174-1180.
6. Skwierczynski, R. D. Molecular Mobility, Disorder, and Solid-State Kinetics: The Two-Environment Model, presented at the 12th Annual Meeting of the American Association of Pharmaceutical Scientists, Boston, MA, November 1997; paper 1541.
7. S. S Leung and co-workers have characterized hydrated and anhydrous aspartame crystals. The dehydration performed in this study was consistent with their results. S. S. Leung, personal communication.
8. Leung, S. S.; Padden, B. E.; Munson, E. J.; Grant, D. J. W. Solid-State Characterization of Two Polymorphs of Aspartame Hemihydrate J. Pharm. Sci. 1998, 87, 501-507.
9. Leung, S. S.; Padden, B. E.; Munson, E. J.; Grant, D. J. W. Hydration and Dehydration Behavior of Aspartame Hemihydrate. J. Pharm. Sci. 1998, 87, 508-513.
10. Laidler, K. J. Chemical Kinetics, 3rd ed.; Harper and Row: New York, 1987, Chapter 4.
11. Connors, K. A. Chemical Kinetics; VCH: New York, 1990, Chapter 5.
12. Leung, S. S.; Padden, B. E.; Munson, E. J.; Grant, D. J. W. Solid State Stability Studies of Model Dipeptides: Aspartame and Aspartylphenylalanine J. Pharm. Sci. 1997, 86, 64-71.
13. The Two-Environment Model has also been used to describe the solid-state kinetics of thermally induced methyl transfer in tetraglycine methyl ester. This reaction is bimolecular. Skwierczynski, R. D.; Shalaev, E. Y.; Byrn, S. R.; Zografi, G. Unpublished results.
14. Skwierczynski, R. D. Application of the Two-Environment Model to Describe the Solid-State Kinetics of Materials in which a Liquid Layer Does Not Exist. Presented at the 8th Annual Symposium on the Molecular Properties of Crystalline and Amorphous Solids in Pharmaceutical Systems, Madison, WI, October 1998.