Deletion of the Trichodiene synthase gene of Fusarium venenatum: Two systems for repeated gene deletions

Fungal Genetics and Biology

Volumn 28, Issue 1, 1999, Pages 68-78

  Royer, John C ^a   Christianson, Lynne M ^a   Yoder, Wendy T ^a   Gambetta, Greg A ^a   Klotz, Alan V ^a   Morris, Carin L ^a   Brody, Howard ^a   Otani, Suzie ^a  

^a NOVO NORDISK INC   (United States)

Author keywords

Acetamidase; Deletion; Fusarium venenatum; Nitrate reductase; Quorn; Replacement; tri5; Tricothecene

Indexed keywords

NITRATE REDUCTASE; SYNTHETASE;

ARTICLE; ASPERGILLUS NIDULANS; CLONING VECTOR; DNA FLANKING REGION; FUSARIUM; GENE DELETION; GENE LIBRARY; HYBRIDIZATION; MOLECULAR CLONING; NEUROSPORA CRASSA; NONHUMAN; PRIORITY JOURNAL;

ASPERGILLUS NIDULANS; FUSARIUM VENENATUM; NEUROSPORA CRASSA;

EID: 0032740127     PISSN: 10871845     EISSN: None     Source Type: Journal    
DOI: 10.1006/fgbi.1999.1162     Document Type: Article

References (31)

1. Alani E., Cao L., Kleckner N. A method for gene disruption that allows repeated use of the URA3 selection in the construction of multiply disrupted yeast strains. Genetics. 116:1987;541-545.
2. Altomare C., Logrieco A., Bottalico A., Mule G., Moretti A., Evidente A. Production of type A trichothecenes and enniatin B by Fusarium sambucinum Fuckel sensu lato. Mycopathologia. 129:1995;177-181.
3. Aprion D. The two-way selection of mutants and revertants in respect of acetate utilization and resistance to fluoro-acetate in Aspergillus nidulans. Genet. Res. Camb. 6:1965;317-329.
4. Cove D. J. The induction and repression of nitrate reductase in the fungus Aspergillus nidulans. Biochem. Biophys. Acta. 113:1966;51-56.
5. Cove D. J. Genetic studies of nitrate assimilation in Aspergillus nidulans. Biol. Rev. 54:1979;291-327.
6. d'Enfert C. Selection of multiple disruption events in Aspergillus fumigatus using the orotidine-5′-decarboxylase gene, pyrG, as a unique transformation marker. Curr. Genet. 30:1996;76-82.
7. Daboussi M. J., Djeballi A., Gerlinger C., Blaiseau P. L., Bouvier I., Cassan M., Lebrun M. H., Parisot D., Brygoo Y. Transformation of seven species of filamentous fungi using the nitrate reductase gene of Aspergillus nidulans. Curr. Genet. 15:1989;453-456.
8. Desjardins A. E., Hohn T. M., McCormick S. P. Trichothecene biosynthesis in Fusarium species: Chemistry, genetics, and significance. Microbiol. Rev. 57:1993;595-604.
9. Fekete C., Logrieco A., Giczey G., Hornok L. Screening of fungi for the presence of the trichodiene synthase encoding sequence by hybridization to the tri5 gene cloned from Fusarium poae. Mycopathologia. 138:1997;91-97.
10. Fu Y-H., Marzluf G. A. Molecular cloning and analysis of the regulation of Nit-3, the structural gene for nitrate reductase in Neurospora crassa. Proc. Natl. Acad. Sci. USA. 84:1987;8243-8247.
11. Fonzi W. A., Irwin M. Y. Isogenic strain construction and gene mapping in Candida albicans. Genetics. 134:1993;717-728.
12. Hohn T. M., Beremand P. D. Isolation and nucleotide sequence of a sesquiterpene cyclase gene from the trichothecene-producing fungus Fusarium sporotrichioides. Gene. 79:1989;131-138.
13. Hohn T. M., Desjardins A. E. Isolation and gene disruption of the tri5 gene encoding trichodiene synthase in Gibberella pulicaris. Mol. Plant-Microbe Interact. 5:1992;249-256.
14. Johnstone L. Letter to the Editor. Fungal Genet. Biol. 25:1998;75.
15. Kelley J. M., Hynes M. Transformation of Aspergillus niger by the amdS gene from Aspergillus nidulans. EMBO. 4:1985;475-479.
16. Lehmbeck, J. 1998, New modified host cells are modified to express reduced levels of metallo-protease and alkaline protease, used to increase production of heterologous protein products.
17. McCormick S. P., Taylor S. L., Plattner R. D., Beremand M. N. Bioconversion of possible T-2 toxin precursors by a mutant strain of Fusarium sporotrichioides NRRL 3229. Appl. Environ. Microbiol. 56:1990;702-706.
18. McLaughlin C. S., Vaughan M. H., Campbell I. M., Wei C. M., Stafford M. E., Hansen B. S. Inhibition of protein synthesis by trichothecenes. Rodricks J. V., Hesseltine C. W., Mehlman M. A. Mycotoxins in Human and Animal Health. 1977;263-273 Pathotox Pub. Park Forest South.
19. Miller J. D., Greenhalgh R., Wang Y., Lu M. Trichothecene chemotypes of three Fusarium species. Mycologia. 83:1991;121-130.
20. O'Donnell K., Cignelik E., Casper H. H. Molecular phylogenetic, morphological, and mycotoxin data support reidentification of the Quorn mycoprotein fungus as Fusarium venenatum. Fungal Genet. Biol. 23:1998;57-67.
21. Proctor R. H., Hohn T. M., McCormick S. P. Reduced virulence of Gibberella zeae caused by disruption of a trichothecene toxin biosynthetic gene. Mol. Plant-Microbe Interact. 8:1995;593-601.
22. Prelusky D. B., Rotter B. A., Rotter R. G. Toxicology of mycotoxins. Miller J. D., Trenholm H. L. Mycotoxins in Grain. Compounds other than Aflatoxin. 1994;359-403 Eagan Press, St. Paul.
23. Royer J. C., Moyer D. L., Reiwitch S. G., Madden M. S., Jensen E. B., Brown S. H., Yonker C. C., Johnstone J. A., Golightly E. J., Yoder W. T., Shuster J. R. Fusarium graminearum A 3/5 as a novel host for heterologous protein production. Bio/Technology. 13:1995;1479-1483.
24. Sambrook J., Fritsch D. F., Maniatis T. Molecular Cloning: A Laboratory Manual. 1989;Cold Spring Harbor Laboratory Press, Cold Spring Harbor.
25. Solomons G. L. Microbial proteins and regulatory clearance for RHM mycoprotein. Moo-Young M., Gregory K. F. Microbial Biomass Proteins. 1986;19-26 Elsevier, New York.
26. Tilburn J. T., Scazzocchio C. W., Taylor G. G., Zabicky-Zissman J. H., Lockington R. A., Davies R. W. Transformation by integration in Aspergillus nidulans. Gene. 26:1983;205-221.
27. Trinci A. P. J. Myco-protein: A twenty-year overnight success story. Mycol. Res. 96:1992;1-13.
28. Ueno Y. Trichothecenes - Chemical, Biological and Toxicological Aspects. 1983;Elsevier.
29. Vogel D. J. Distribution of lysine pathways among fungi: Evolutionary implications. Am. Nat. 98:1964;435-446.
30. Yoder W. T., Christianson L. M. Species-specific primers resolve members of Fusarium section Fusarium. Re-evaluation of the taxonomic status of the edible Quorn fungus. Fungal Genet. Biol. 23:1998;68-80.
31. Weibe M. G., Robson G. D., Trinci A. P. J., Oliver S. G. Characterization of morphological mutants generated spontaneously in glucose-limited, continuous flow cultures of Fusarium graminearum A3/5. Mycol. Res. 96:1992;555-562.