Escherichia coli Lrp (leucine-responsive regulatory protein) does not directly regulate expression of the leu operon promoter

Journal of Bacteriology

Volumn 181, Issue 20, 1999, Pages 6547-6551

  Landgraf, Jeffrey R ^a,b   Boxer, Jonathan A ^a   Calvo, Joseph M ^a  

^a Department of Obstetrics Gynecology   (United States)

^b MICHIGAN STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

LEUCINE; REGULATOR PROTEIN;

AMINO ACID SYNTHESIS; ARTICLE; ESCHERICHIA COLI; GENE CONTROL; GENE EXPRESSION REGULATION; GENE MUTATION; NONHUMAN; OPERON; PRIORITY JOURNAL; PROMOTER REGION;

ESCHERICHIA COLI; NEGIBACTERIA; PROKARYOTA;

EID: 0032738832     PISSN: 00219193     EISSN: None     Source Type: Journal    
DOI: 10.1128/jb.181.20.6547-6551.1999     Document Type: Article

References (25)

1. Abouhamad, W. N., M. Manson, M. M. Gibson, and C. F. Higgins. 1991. Peptide transport and chemotaxis in Escherichia coli and Salmonella typhimurium: characterization of the dipeptide permease (Dpp) and the dipeptide-binding protein. Mol. Microbiol. 5:1035-1047.
2. Ambartsoumian, G., R. D'Ari, R. T. Lin, and E. B. Newman. 1994. Altered amino acid metabolism in lrp mutants of E. coli K-12 and their derivatives. Microbiology 140:1737-1744.
3. Bhagwat, S. P., M. R. Rice, R. G. Matthews, and R. M. Blumenthal. 1997. Use of an inducible regulatory protein to identify members of a regulon: application to the regulon controlled by the leucine-responsive regulatory protein (Lrp) in Escherichia coli. J. Bacteriol. 179:6254-6263.
4. Calvo, J. M., and R. G. Matthews. 1994. The leucine-responsive regulatory protein (Lrp), a global regulator of metabolism in Escherichia coli. Microbiol. Rev. 58:466-490.
5. D'Ari, R., R. T. Lin, and E. B. Newman. 1993. The leucine-responsive regulatory protein: more than a regulator? Trends Biochem. Sci. 18:260-263.
6. Fang, M., and H.-Y. Wu. 1998. A promoter relay mechanism for sequential gene activation. J. Bacteriol. 180:626-633.
7. + Salmonella typhimurium strains. J. Biol. Chem. 273:29929-29934.
8. Gemmill, R. M., S. R. Wessler, E. B. Keller, and J. M. Calvo. 1979. The leucine operon of Salmonella typhimurium is controlled by an attenuation mechanism. Proc. Natl. Acad. Sci. USA 76:4941-4945.
9. Georgiou, G., M. L. Schuler, and D. B. Wilson. 1988. Release of periplasmic enzymes and other physiological effects of β-lactamase overproduction in Escherichia coli. Biotechnol. Bioeng. 32:741-748.
10. Haney, S. A., J. V. Platko, D. L. Oxender, and J. M. Calvo. 1992. Lrp, a leucine-responsive protein, regulates branched-chain amino acid transport genes in Escherichia coli. J. Bacteriol. 174:108-115.
11. Haughn, G. W., C. H. Squires, M. DeFelice, C. T. Lago, and J. M. Calvo. 1985. Unusual organization of the ilvIH promoter of Escherichia coli. J. Bacteriol. 163:186-198.
12. Landgraf, J. R., M. Levinthal, and A. Danchin. 1994. The role of H-NS in one carbon metabolism. Biochimie 76:1063-1070.
13. Landgraf, J. R., J. Wu, and J. M. Calvo. 1996. The effect of nutrition and growth rate upon Lrp levels in Escherichia coli. J. Bacteriol. 178:6930-6936.
14. Lin, R., R. D'Ari, and E. B. Newman. 1992. placMu insertions in genes of the leucine regulon: extension of the regulon to genes not regulated by leucine. J. Bacteriol. 174:1948-1955.
15. Miller, J. H. 1972. Experiments in molecular genetics, p. 352-355. Cold Spring Harbor Laboratory, Cold Spring Harbor, N.Y.
16. Newman, E. B., T. T. Lin, and R. D'Ari. 1996. The leucine/Lrp regulon, p. 1513-1525. In F. C. Neidhardt, R. Curtiss III, J. L. Ingraham, E. C. C. Lin, K. B. Low, B. Magasanik, W. S. Reznikoff, M. Riley, M. Schaechter, and H. E. Umbarger (ed.), Escherichia coli and Salmonella: cellular and molecular biology, 2nd ed., vol. 1. ASM Press, Washington, D.C.
17. Olson, E. R., D. S. Dunyak, L. M. Jurss, and R. A. Poorman. 1991. Identification and characterization of dppA, an Escherichia coli gene encoding a periplasmic dipeptide transport protein. J. Bacteriol. 173:234-244.
18. Platko, J. V., D. A. Willins, and J. M. Calvo. 1990. The ilvIH operon of Escherichia coli is positively regulated. J. Bacteriol. 172:4563-4570.
19. Searles, L. L., and J. M. Calvo. 1988. Permeabilized cell and radiochemical assays for β-isopropylmalate dehydrogenase. Methods Enzymol. 166:225-229.
20. Simons, R. W., F. Houman, and N. Kleckner. 1987. Improved single and multicopy lac-based cloning vectors for protein and operon fusions. Gene 53:85-96.
21. Stieglitz, B. I., and J. M. Calvo. 1974. Distribution of the isopropylmalate pathway to leucine among diverse bacteria. J. Bacteriol. 118:935-941.
22. Tchetina, E., and E. B. Newman. 1995. Identification of Lrp-regulated genes by inverse PCR and sequencing: regulation of two mal operons of Escherichia coli by leucine-responsive regulatory protein. J. Bacteriol. 177:2679-2683.
23. Umbarger, H. E. 1996. Biosynthesis of the branched-chain amino acids, p. 352-367. In F. C. Neidhardt, R. Curtis III, J. L. Ingraham, E. C. C. Lin, K. B. Low, B. Magasanik, W. S. Reznikoff, M. Riley, M. Schaechter, and H. E. Umbarger (ed.), Escherichia coli and Salmonella typhimurium: cellular and molecular biology, 2nd ed., vol. 1. American Society for Microbiology, Washington, D.C.
24. Wang, Q., J. Wu, D. Friedberg, J. Platko, and J. M. Calvo. 1994. Regulation of the Escherichia coli lrp gene. J. Bacteriol. 176:1831-1839.
25. Wessler, S. R., and J. M. Calvo. 1981. Control of leu operon expression in Escherichia coli by a transcription attenuation mechanism. J. Mol. Biol. 149:579-597.