The anticonvulsant BW534U87 depresses epileptiform activity in rat hippocampal slices by an adenosine-dependent mechanism and through inhibition of voltage-gated Na+ channels

British Journal of Pharmacology

Volumn 128, Issue 5, 1999, Pages 1011-1020

  Dupere, Joe R B ^a   Dale, Tim J ^a   Starkey, Sarah J ^a   Xie, Xinmin ^a  

^a GLAXOSMITHKLINE   (United Kingdom)

Author keywords

Adenosine; Adenosine deaminase; Anticonvulsant; BW534U87; EHNA; Hippocampal slices; Intracellular recording; Lamotrigine; Na+ channels; Patch clamp recording

Indexed keywords

ADENOSINE; ADENOSINE DEAMINASE INHIBITOR; ADENOSINE RECEPTOR BLOCKING AGENT; ANTICONVULSIVE AGENT; BW 534U87; SODIUM CHANNEL; SODIUM ION; THEOPHYLLINE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BRAIN SLICE; CHANNEL GATING; CHO CELL; EPILEPTIC DISCHARGE; HIPPOCAMPUS; NONHUMAN; PRIORITY JOURNAL; RAT; VOLTAGE CLAMP;

ACTION POTENTIALS; ADENINE; ADENOSINE; ADENOSINE DEAMINASE; ANIMALS; ANTICONVULSANTS; BRAIN CHEMISTRY; CHO CELLS; CRICETINAE; ELECTROPHYSIOLOGY; ENZYME INHIBITORS; EPILEPSY; FEMALE; HIPPOCAMPUS; ION CHANNEL GATING; MAGNESIUM; MALE; PATCH-CLAMP TECHNIQUES; RATS; RATS, SPRAGUE-DAWLEY; SODIUM CHANNELS; TRIAZOLES;

EID: 0032738669     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0702881     Document Type: Article

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