Effects of continuous opioid receptor blockade on alcohol intake and up- regulation of opioid receptor subtype signalling in a genetic model of high alcohol drinking

Naunyn-Schmiedeberg's Archives of Pharmacology

Volumn 360, Issue 4, 1999, Pages 391-401

  Hyytiä, Petri ^a   Ingman, Kimmo ^b   Soini, Sanna L ^b   Laitinen, Jarmo T ^c   Korpi, Esa R ^b  

^a NATIONAL PUBLIC HEALTH INSTITUTE   (Finland)

^b UNIVERSITY OF TURKU   (Finland)

^c UNIVERSITY OF EASTERN FINLAND   (Finland)

Author keywords

35S GTP S autoradiography; Alcohol drinking; Naloxone; Opioid receptor subtypes; Receptor up regulation

Indexed keywords

NALOXONE; OPIATE ANTAGONIST; RECEPTOR SUBTYPE;

ALCOHOL CONSUMPTION; ALCOHOLISM; ANIMAL EXPERIMENT; ARTICLE; BINDING SITE; CONTROLLED STUDY; DRUG EFFECT; LIGAND BINDING; NONHUMAN; RAT;

ALCOHOL DRINKING; ANALGESIA; ANIMALS; AUTORADIOGRAPHY; DOSE-RESPONSE RELATIONSHIP, DRUG; DRINKING; DRUG INTERACTIONS; EATING; GTP-BINDING PROTEINS; GUANOSINE 5'-O-(3-THIOTRIPHOSPHATE); LIGANDS; MALE; MORPHINE; NALOXONE; NARCOTIC ANTAGONISTS; RATS; RECEPTORS, OPIOID; TIME FACTORS; UP-REGULATION;

EID: 0032738438     PISSN: 00281298     EISSN: None     Source Type: Journal    
DOI: 10.1007/s002109900070     Document Type: Article

References (64)

1. Ahtee L, Attila LMJ, Carlson KR (1990) Augmentation of morphine-induced changes in brain monoamine metabolism after chronic naltrexone treatment. J Pharmacol Exp Ther 255:803-808
2. Altshuler HL, Phillips PE, Feinhandler DA (1980) Alterations of ethanol self-administration by naltrexone. Life Sci 26:679-688
3. Bardo MT, Neisewander JL (1987) Chronic naltrexone supersensitizes the reinforcing and locomotor-activating effects of morphine. Pharmacol Biochem Behav 28:267-273
4. Beaman CM, Hunter GA, Dunn LL, Reid LD (1984) Opioids, benzodiazepines and intake of ethanol. Alcohol 1:39-42
5. Cornish JW, Henson D, Levine S, Volpicelli J, Inturrisi CE, Yoburn BC, O'Brien CP (1993) Naltrexone maintenance: effect on morphine sensitivity in normal volunteers. Am J Addict 2:34-38
6. Crews FT, Overstreet DH, Kampov-Polevoi AB, Bartus RT (1998) Tolerance to the suppressive effects of naloxone on alcohol intake is accompanied by increases in mu opiate receptors. Soc Neurosci Abstr 24:1478
7. Davidson D, Amit Z (1996) Effects of naloxone on limited-access ethanol drinking in rats. Alcohol Clin Exp Ther 20:664-669
8. De Waele J-P, Papachristou DN, Gianoulakis C (1992) The alcohol-preferring C57BL/6 mice present an enhanced sensitivity of the hypothalamic β-endorphin system to ethanol than the alcohol-avoiding DBA2 mice. J Pharmacol Exp Ther 261:788-794
9. Dingledine R, Iversen LL, Breuker E (1978) Naloxone as a GABA antagonist: evidence from iontophoretic, receptor binding and convulsant studies. Eur J Pharmacol 47:19-27
10. Eriksson K (1968) Genetic selection for voluntary alcohol consumption in the albino rat. Science 159:739-741
11. Froehlich JC (1995) Genetic factors in alcohol self-administration. J Clin Psychiatry 56 [Suppl 7]:15-23
12. Froehlich JC, Harts J, Lumeng L, Li T-K (1990) Naloxone attenuates voluntary ethanol intake in rats selectively bred for high ethanol preference. Pharmacol Biochem Behav 35:385-390
13. Froehlich JC, Zweifel M, Harts, J, Lumeng L, Li T-K (1991) Importance of delta opioid receptors in maintaining high alcohol drinking. Psychopharmacology 103:467-472
14. Gianoulakis C (1996) Implication of endogenous opioids and dopamine in alcoholism: human and basic science studies. Alcohol Alcohol 31 [Suppl 1]:33-42
15. Gianoulakis C, Béliveau D, Angelogianni P, Meaney M, Thavundayil J, Tawar V, Dumas M (1989) Different pituitary β-endorphin and adrenal cortisol response to ethanol in individuals with high and low risk for future development of alcoholism. Life Sci 45:1097-1109
16. Gianoulakis C, Waele J-P de, Kiianmaa K (1992) Differences in the brain and pituitary β-endorphin system between the alcohol-preferring AA and alcohol-avoiding ANA rats. Alcohol Clin Exp Res 16:453-459
17. Goodman RR, Snyder SH, Kuhar MJ, Young WS III (1980) Differentiation of delta and mu opiate receptor localizations by light microscopic autoradiography. Proc Natl Acad Sci USA 77:6239-6243
18. Gulya K, Gehlert DR, Wamsley JK, Mosberg H, Hruby VJ, Yamamura HI (1986) Light microscopic autoradiographic localization of delta opioid receptors in the rat brain using a highly selective bis-penicillamine cyclic enkephalin analog. J Pharmacol Exp Ther 238:720-726
19. Herz A (1997) Endogenous opioid systems and alcohol addiction. Psychopharmacology 129:99-111
20. Hill KG, Kiefer SW (1997) Naltrexone treatment increases the aversiveness of alcohol for outbred rats. Alcohol Clin Exp Res 21:637-641
21. 1- but not by a δ-opioid receptor antagonist in alcohol-preferring rats. Eur J Pharmacol 304:7-13
22. Hubbell CL, Czirr SA, Hunter GA, Beaman CM, LeCann NC, Reid LD (1986) Consumption of ethanol solution is potentiated by morphine and attenuated by naloxone across repeated daily administrations. Alcohol 3:39-54
23. Hubbell CL, Czirr S, Reid LD (1987) Persistence and specificity of small doses of morphine on intake of alcoholic beverages. Alcohol 4:149-156
24. Hubbell CL, Marglin SH, Spitalnic SJ, Abelson ML, Wild KD, Reid LD (1991) Opioidergic, serotonergic, and dopaminergic manipulations and rats' intake of a sweetened alcoholic beverage. Alcohol 8:355-367
25. Hyytiä P (1993) Involvement of μ-opioid receptors in alcohol drinking by alcohol-preferring AA rats. Pharmacol Biochem Behav 45:697-701
26. Iso H, Brush FR (1991) Opposite effects of naltrexone on ETOH intake by Syracuse high and low avoidance rats. Alcohol 8:443-448
27. Kornet M, Goosen C, Van Ree JM (1991) Effect of naltrexone on alcohol consumption during chronic alcohol drinking and after a period of imposed abstinence in free-choice drinking rhesus monkeys. Psychopharmacology 104:367-376
28. Krishnan-Sarin S, Jing S-L, Kurtz DL, Zweifel M, Portoghese PS, Li T-K, Froehlich JC (1995a) The delta opioid receptor antagonist naltrindole attenuates both alcohol and saccharin intake in rats selectively bred for alcohol preference. Psychopharmacology 120:177-185
29. Krishnan-Sarin S, Portoghese PS, Li T-K, Froehlich JC (1995b) The delta2-opioid receptor antagonist naltriben selectively attenuates alcohol intake in rats bred for alcohol preference. Pharmacol Biochem Behav 52:153-159
30. Krishnan-Sarin S, Wand GS, Li XW, Portoghese PS, Froehlich JC (1998) Effect of mu opioid receptor blockade on alcohol intake in rats bred for high alcohol drinking. Pharmacol Biochem Behav 59:627-635
31. 35S]GTP autoradiography allows region-specific detection of muscarinic receptor-dependent G-protein activation in the chick optic tectum. Brain Res 769:21-28
32. 35S]guanosine 5′-[γ-thio]triphosphate autoradiography. Neuroscience (in press)
33. 3 receptor-dependent G protein activation in rat brain tissue sections. J Neurochem 71:808-816
34. Lê AD, Poulos CX, Quan B, Chow S (1993) The effects of selective blockade of delta and mu opiate receptors on ethanol consumption by C57BL/6 mice in a restricted access paradigm. Brain Res 630:330-332
35. Le Blanc AE, Cappell H (1975) Antagonism of morphine-induced aversive conditioning by naloxone. Pharmacol Biochem Behav 3:185-188
36. Lee MC, Wagner HN Jr, Tanada S, Frost JJ, Bice AN, Dannals RF (1988) Duration of occupancy of opiate receptors by naltrexone. J Nucl Med 29:1207-1211
37. Mansour A, Lewis ME, Khachaturian H, Akil H, Watson SJ (1986) Pharmacological and anatomical evidence of selective mu, delta, and kappa opioid receptor binding in rat brain. Brain Res 399:69-79
38. Mansour A, Lewis ME, Khachaturian H, Akil H, Watson SJ (1987) Autoradiographic differentiation of mu, delta, and kappa opioid receptors in the rat forebrain and midbrain. J Neurosci 7:2445-2464
39. Mansour A, Thompson RC, Akil H, Watson SJ (1993) Delta opioid receptor mRNA distribution in the brain: comparison to delta receptor binding and proenkephalin mRNA. J Chem Neuroanat 6:351-362
40. Mansour A, Fox CA, Thompson RC, Akil H, Watson SJ (1994) μ-Opioid receptor mRNA expression in the rat CNS: comparison to μ-receptor binding. Brain Res 643:245-265
41. Millan MJ, Morris BJ, Herz A (1988) Antagonist-induced opioid receptor up-regulation. I. Characterization of supersensitivity to selective mu and kappa agonists. J Pharmacol Exp Ther 247:721-728
42. Morris BJ, Millan MJ, Herz A (1988) Antagonist-induced opioid receptor up-regulation. II. Regionally specific modulation of mu, delta and kappa binding sites in rat brain revealed by quantitative autoradiography. J Pharmacol Exp Ther 247:729-736
43. 3H]ethylketocyclazocine. Life Sci 42:2403-2412
44. Nylander I, Hyytiä P, Forsander O, Terenius L (1994) Differences between alcohol-preferring (AA) and alcohol-avoiding (ANA) rats in the prodynorphin and proenkephalin systems. Alcohol Clin Exp Res 18:1272-1279
45. O'Malley SS, Jaffe AJ, Chang G, Schottenfeld RS, Meyer RE, Rounsaville B (1992) Naltrexone and coping skills therapy for alcohol dependence: a controlled study. Arch Gen Psychiatry 49:881-887
46. O'Malley SS, Jaffe AJ, Chang G, Rode S, Schottenfeld R, Meyer RE, Rounsaville B (1996) Six-month follow-up of naltrexone and psychotherapy for alcohol dependence. Arch Gen Psychiatry 53:217-224
47. Paronis CA, Holtzman SG (1991) Increased analgesic potency of mu agonists after continuous naloxone infusion in rats. J Pharmacol Exp Ther 259:582-589
48. Paxinos G, Watson C (1986) The rat brain in stereotaxic coordinates, 2nd edn. Academic Press, San Diego
49. Phillips TJ, Wenger CD, Dorow JD (1997) Naltrexone effects on ethanol drinking acquisition and on established ethanol consumption in C57BL/6J mice. Alcohol Clin Exp Res 21:691-702
50. Schenk S, Nawiesniak E (1985) Chronic naltrexone treatment increases the heroin-produced facilitation of self-stimulation. Pharmacol Biochem Behav 22:175-177
51. Schwarz-Stevens KS, Files FJ, Samson HH (1992) Effects of morphine and naloxnne on ethanol- and sucrose-reinforced responding in nondeprived rats. Alcohol Clin Exp Res 16:822-832
52. 35S]thio]-triphosphate binding. Proc Natl Acad Sci USA 92:7242-7246
53. Sinclair JD (1992) Drugs to decrease alcohol drinking. Ann Med 22:357-362
54. Sinclair JD, Hyytiä P, Nurmi M (1992) The limited access paradigm: description of one method. Alcohol 9:441-444
55. Tempel A, Gardner EL, Zukin RS (1984) Visualization of opiate receptor upregulation by light microscopy autoradiography. Proc Natl Acad Sci USA 81:3893-3897
56. Tempel A, Gardner EL, Zukin RS (1985) Neurochemical and functional correlates of naltrexone-induced opiate receptor upregulation. J Pharmacol Exp Res 232:439-444
57. Van Der Kooy D, Phillips AG (1977) Temporal analysis of naloxone attenuation of morphine-induced taste aversion. Pharmacol Biochem Behav 6:637-641
58. Volpicelli JR, Alterman AI, Hayashida M, O'Brien CP (1992) Naltrexone in the treatment of alcohol dependence. Arch Gen Psychiatry 49:876-880
59. Wegelius K, Honkanen A, Korpi ER (1994) Benzodiazepine receptor ligands modulate ethanol drinking in alcohol-preferring rats. Eur J Pharmacol 263:141-147
60. Weiss F, Mitchiner M, Bloom FE, Koob GF (1990) Free-choice responding for ethanol versus water in alcohol preferring (P) and unselected Wistar rats is differentially modified by naloxone, bromocriptine, and methysergide. Psychopharmacology 101:178-186
61. Yoburn BC, Nunes FA, Adler B, Pasternak GW, Inturrisi CE (1986) Pharmacodynamic supersensitivity and opioid receptor upregulation in the mouse. J Pharmacol Exp Ther 239:132-135
62. Yoburn BC, Luke MC, Pasternak GW, Inturrisi CE (1988) Upregulation of opioid receptor subtypes correlates with potency changes of morphine and DADLE. Life Sci 43:1319-1324
63. Yoburn BC, Sierra V, Lutfy K (1989) Chronic opioid antagonist treatment: assessment of receptor upregulation. Eur J Pharmacol 170:193-200
64. Zukin RS, Sugerman JR, Fitz-Syage ML, Gardner EL, Zukin SR, Gintzler AR (1982) Naltrexone-induced opiate receptor supersensitivity. Brain Res 245:285-292