Glomerular epithelial-myofibroblast transdifferentiation in the evolution of glomerular crescent formation

Nephrology Dialysis Transplantation

Volumn 14, Issue 12, 1999, Pages 2860-2872

  Ng, Yee Yung ^a   Fan, Jun Ming ^b   Mu, Wei ^b   Nikolic Paterson, David J ^b   Yang, Wu Chang ^a   Huang, Tung Po ^a   Atkins, Robert C ^b   Lan, Hui Y ^b,c  

^a NATIONAL YANG MING UNIVERSITY   (Taiwan)

^b MONASH UNIVERSITY   (Australia)

^c MONASH MEDICAL CENTRE   (Australia)

Author keywords

Glomerular crescents; Glomerular epithelial cells; Glomerulonephritis; Myofibroblasts; Transdifferentiation

Indexed keywords

ALPHA ACTIN; UVOMORULIN;

ACTIN FILAMENT; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL DIFFERENTIATION; CELL ULTRASTRUCTURE; CONTROLLED STUDY; GLOMERULUS BASEMENT MEMBRANE; GLOMERULUS EPITHELIUM; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION; KIDNEY FIBROSIS; MALE; MYOFIBROBLAST; NEPHRECTOMY; NONHUMAN; PRIORITY JOURNAL; RAT;

EID: 0032738399     PISSN: 09310509     EISSN: None     Source Type: Journal    
DOI: 10.1093/ndt/14.12.2860     Document Type: Article

References (52)

1. Kerr PG, Lan HY, Atkins RC. Rapidly progressive glomerulonephritis. In: Schrier RW, Gottschalk CW, ed. Diseases of the Kidney. Little, Brown and Co, Boston, 1996; 1619-1644
2. Cattell V, Jamieson SW. The origin of glomerular crescents in experimental nephrotoxic serum nephritis in the rabbit. Lab Invest 1978; 39: 584-590
3. Hancock WW, Atkins RC. Cellular composition of crescents in human rapidly progressive glomerulonephritis identified using monoclonal antibodies. Am J Nephrol 1984; 4: 177-181
4. Magil AB. Histogenesis of glomerular crescents: immunohistochemical demonstration of cytokeratin in crescent cells. Am J Pathol 1985; 120:222-229
5. Boucher A, Droz D, Adafer E, Noel LH. Relationship between the integrity of Bowman's capsule and the composition of cellular crescents in human crescentic glomerulonephritis. Lab Invest 1987; 56: 526-533
6. Lan HY, Nikolic-Paterson DJ, Mu W, Atkins RC. Local macrophage proliferation in the pathogenesis of glomerular crescent formation in rat anti-glomerular basement membrane (GBM) glomerulonephritis. Clin Exp Immunol 1997; 110: 233-240
7. Ophascharoensuk V, Pippin JW, Gordon KL, Shankland SJ, Couser WG, Johnson RJ. Role of intrinsic renal cells versus infiltrating cells in glomerular crescent formation. Kidney Int 1998; 54: 416-425
8. Atkins RC, Nikolic-Paterson DJ, Song Q, Lan HY. Modulation of crescentic glomerulonephritis. J Am Soc Nephrol 1996; 7: 2271-2278
9. Morel-Maroger Striker L, Killen PD, Chi E, Striker GE. The composition of glomerulosclerosis. I. Studies in focal sclerosis, crescentic glomerulonephritis, and membranoproliferative glomerulonephritis. Lab Invest 1984; 51: 181-192
10. Silva FG, Hoyer JR, Pirani CL. Sequential studies of glomerular crescent formation in rats with antiglomerular basement membrane-induced glomerulonephritis and the role of coagulation factors. Lab Invest 1984; 51: 404-415
11. Lan HY, Nikolic-Paterson DJ, Atkins RC. Involvement of activated periglomerular leukocytes in the rupture of Bowman's capsule and glomerular crescent progression in experimental glomerulonephritis. Lab Invest 1992; 67: 743-751
12. Hogemann B, Gillessen A, Bocker W, Rauterberg J, Domschke W. Myofibroblast-like cells produce mRNA for type I and III procollagens in chronic active hepatitis. Scand J Gastroenterol 1993; 28: 591-594
13. Zhang K, Rekhter MD, Gordon D, Phan SH. Myofibroblasts and their role in lung collagen gene expression during pulmonary fibrosis. A combined immunohistochemical and in situ hybridization study. Am J Pathol 1994; 145: 114-125
14. 1 (III) collagen expression in experimental tubulointerstitial nephritis. Kidney Int 1997; 51: 926-931
15. Goumenos DS, Brown CB, Shortland J, El Nahas AM. Myofibroblasts, predictors of progression of mesangial IgA nephropathy? Nephrol Dial Transplant 1994; 9: 1418-1425
16. Hewitson TD, Becker GJ. Interstitial myofibroblasts in IgA glomerulonephritis. Am J Nephrol 1995; 15; 111-117
17. Hewitson TD, Wu HL, Becker GJ. Interstitial myofibroblasts in experimental renal infection and scarring. Am J Nephrol 1995; 15: 411-417
18. Zhang G, Moorhead PJ, El Nahas AM. Myofibroblasts and the progression of experimental glomerulonephritis. Exp Nephrol 1995; 3: 308-318
19. Roberts IS, Burrows C, Shanks JH, Venning M, McWilliam U. Interstitial myofibroblasts: predictors of progression in membranous nephropathy. J Clin Pathol 1997; 50: 123-127
20. Essawy M, Soylemezoglu O, Muchaneta-Kubara EC, Shortland J, Brown CB, El Nahas AM. Myofibroblasts and the progression of diabetic nephropathy. Nephrol Dial Transplant 1997; 12: 43-50
21. Kliem V, Johnson RJ, Alpers CE et al. Mechanisms involved in the pathogenesis of tubulointerstitial fibrosis in 5/6-nephrectomized rats. Kidney Int 1996; 49: 666-678
22. Lan HY, Paterson DJ, Atkins RC. Initiation and evolution of interstitial leukocytic infiltration in experimental glomerulonephritis. Kidney Int 1991; 40: 425-433
23. Dijkstra CD, Dopp EA, Joling P, Kraal G. The heterogeneity of mononuclear phagocytes in lymphoid organs: distinct macrophage subpopulations in the rat recognized by monoclonal antibodies ED1, ED2 and ED3. Immunology 1985; 54: 589-599
24. Mason DW, Williams AF. The kinetics of antibody binding to membrane antigens in solution and at the cell surface. Biochem J. 1980; 187: 1-20
25. Lan HY, Mu W, Nikolic-Paterson DJ, Atkins RC. A novel, simple, reliable, and sensitive method for multiple immunoenzyme staining: use of microwave oven heating to block antibody crossreactivity and retrieve antigens. J Histochem Cytochem 1995; 43: 97-102
26. Ng YY, Nikolic-Paterson DJ, Mu W, Atkins RC, Lan HY. Expression of basic fibroblast growth factor and its receptor in the progression of rat crescentic glomerulonephritis. Nephrology 1995; 1: 569-575
27. McHugh KM, Lessard JL. The nucleotide sequence of a rat vascular smooth muscle alpha-actin cDNA. Nucleic Acids Res 1988; 16: 4167
28. Qian SW, Kondaiah P, Roberts AB, Sporn MB. cDNA cloning by PCR of rat transforming growth factor beta-1. Nucleic Acids Res 1990; 18: 3059
29. Lan HY, Mu W, Ng YY, Nikolic-Paterson DJ, Atkins RC. A simple, reliable, and sensitive method of nonradioactive in situ hybridization: use of microwave heating to improve hybridization efficiency and preserve tissue morphology. J Histochem Cytochem 1996; 44: 281-287
30. Ekblom P, Weller A. Ontogeny of tubulointerstitial cells. Kidney Int 1991; 39: 394-400
31. Hay ED, Zuk A. Transformations between epithelium and mesenchyme: normal, pathological, and experimentally induced. Am J Kidney Dis 1995; 26: 678-690
32. Okada H, Danoff TM, Kalluri R, Neilson EG. Early role of Fsp1 in epithelial-mesenchymal transformation. Am J Physiol 1997; 273: F563-574
33. Strutz F, Okada H, Lo CW et al. Identification and characterization of a fibroblast marker: FSPI. J Cell Biol 1995; 130: 393-405
34. Strutz F. Novel aspects of renal fibrogenesis. Nephrol Dial Transplant 1995; 10: 1526-1532
35. Zuk A, Hay ED. Expression of beta 1 integrins changes during transformation of avian lens epithelium to mesenchyme in collagen gels. Dev Dyn 1994; 201: 378-393
36. Zuk A, Matlin KS, Hay ED. Type I collagen gel induces Madin-Darby canine kidney cells to become fusiform in shape and lose apical-basal polarity. J Cell Biol 1989; 108: 903-919
37. Yang N, Wu LL, Nikolic-Paterson DJ et al. Local macrophage and myofibroblast proliferation in progressive renal injury in the rat remnant kidney. Nephrol Dial Transplant 1998; 13: 1967-1974
38. Creely JJ, DiMari SJ, Howe AM, Haralson MA. Effects of transforming growth factor-beta on collagen synthesis by normal rat kidney epithelial cells. Am J Pathol 1992; 140: 45-55
39. Jouanneau J, Gavrilovic J, Caruelle D et al. Secreted or non-secreted forms of acidic fibroblast growth factor produced by transfected epithelial cells influence cell morphology, motility, and invasive potential. Proc Natl Acad Sci USA 1991; 88: 2893-2897
40. Potts JD, Dagle JM, Walder JA, Weeks DL, Runyan RB. Epithelial-mesenchymal transformation of embryonic cardiac endothelial cells is inhibited by a modified antisense oligodeoxy-nucleotide to transforming growth factor beta 3. Proc Natl Acad Sci USA 1991; 88: 1516-1520
41. Sun D, Vanderburg CR, Odierna GS, Hay ED. TGFbeta3 promotes transformation of chicken palate medial edge epithelium to mesenchyme in vitro. Development 1998; 125: 95-105
42. Heikinheimo K, Happonen RP, Miettinen PJ, Ritvos O. Transforming growth factor beta 2 in epithelial differentiation of developing teeth and odontogenic tumors. J Clin Invest 1993; 91: 1019-1027
43. Miettinen PJ, Ebner R, Lopez AR, Derynck R. TGF-beta induced transdifferentialion of mammary epithelial cells to mesenchymal cells: involvement of type I receptors. J Cell Biol 1994; 127: 2021-2036
44. Wu LL, Cox A, Roe CJ, Dziadek M, Cooper ME, Gilbert RE. Transforming growth factor beta 1 and renal injury following subtotal nephrectomy in the rat: role of the renin-angiotensin system. Kidney Int 1997; 51: 1553-1567
45. Klein G, Langegger M, Timpl R, Ekblom P. Role of laminin A chain in the development of epithelial cell polarity. Cell 1988; 55: 331-341
46. Boyer B, Thiery JP. Epithelium-mesenchyme interconversion as example of epithelial plasticity. APMIS 1993; 101: 257-268
47. Ng YY, Huang TP, Yang WC et al. Evidence for tubular epithelial-myofibroblast transdifferentiation in progressive tubulointerstitial fibrosis in 5/6 nephrectomized rats. Kidney Int 1998; 53: 864-876
48. Behrens J, Birchmeier W, Goodman SL. Dissociation of Madin-Darby canine kidney epithelial cells by the monoclonal antibody anti-Arc-1: Mechanistic aspects and identification of the antigen as a component related to uvomorulin. J Cell Biol 1985; 101: 1307-1315
49. Behrens J, Mareel MM, Van Roy FM, Birchmeier W. Dissecting tumor cells invasion: Epithelial cells acquire invasive properties after the loss of uvomorulin-mediated cell-cell adhesion. J Cell Biol 1989; 108: 2435-2447
50. Vleminckx K, Vakaet L, Mareel M, Fiers W, Van Roy F. Genetic manipulation of E-cadherin expression by epithelial tumor cells reveals an invasion suppressor role. Cell 1991; 66: 107-119
51. Gressner AM. Transdifferentiation of hepatic stellate cells (Ito cells) to myofibroblasts: a key event in hepatic fibrogenesis. Kidney Int 1996; 54 [Suppl]: S39-45
52. Tang L, Tanaka Y, Marumo F, Sato C. Phenotypic change in portal flbroblasts in biliary fibrosis. Liver 1994; 14: 76-84