Immunocytochemical assessment of bone marrow aspirates for monitoring response to chemotherapy in small-cell lung cancer patients

British Journal of Cancer

Volumn 81, Issue 7, 1999, Pages 1213-1221

  Pelosi, G ^a   Pasini, F ^b   Ottensmeier, C ^c   Pavanel, F ^b   Bresaola, E ^b   Bonetti, A ^b   Fraggetta, F ^a   Terzi, A ^d   Iannucci, A ^d   Cetto, G L ^b  

^a EUROPEAN INSTITUTE OF ONCOLOGY   (Italy)

^b UNIVERSITY OF VERONA   (Italy)

^c UNIVERSITY HOSPITAL SOUTHAMPTON NHS FOUNDATION TRUST   (United Kingdom)

^d UNIVERSITY HOSPITAL OF VERONA   (Italy)

Author keywords

Bone marrow; Chemotherapy; Immunocytochemistry; Micrometastases; Prognosis; SCLC

Indexed keywords

ANTIBODY; CARBOPLATIN; CYCLOPHOSPHAMIDE; DOXORUBICIN; ETOPOSIDE; IFOSFAMIDE; NERVE CELL ADHESION MOLECULE; TENIPOSIDE; VINCRISTINE;

ADULT; AGED; ARTICLE; BONE MARROW BIOPSY; BONE MARROW PURGING; CANCER CHEMOTHERAPY; CANCER SURVIVAL; CLINICAL ARTICLE; FEMALE; HUMAN; HUMAN CELL; IMMUNOCYTOCHEMISTRY; LUNG SMALL CELL CANCER; MALE; MULTIVARIATE ANALYSIS; PRIORITY JOURNAL; TUMOR CELL;

EID: 0032738360     PISSN: 00070920     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjc.6690831     Document Type: Article

References (56)

1. Abrams J, Doyle LA and Aisner J (1988) Staging, prognostic factors, and special considerations in small cell lung cancer. Semin Oncol 15: 261-277
2. Acheson A, Sunshine JL and Rutishauer U (1991) N-CAM polysialic acid can regulate both cell -cell and cell substrate interactions. J Cell Biol 114: 143-153
3. Beiske K, Myklebust AT, Aamdal S, Langholm R, Jakobsen E and Fodstad O (1992) Detection of bone marrow metastases in small cell lung cancer patients. Comparison of immunologic and morphologic methods. Am J Pathol 141: 531-538
4. Berendsen HH, De Leij L, Postmus PE, Ter Haar JG, Poppema S and The TH (1988) Detection of small cell lung cancer metastases in bone marrow aspirates using monoclonal antibody directed against neuroendocrine differentiation antigen. J Clin Pathol 41: 273-276
5. Brugger W, Bross KJ, Glatt M, Weber F, Martelsmann R and Kanz L (1994) Mobilization of tumor cells and hematopoietic progenitor cells into peripheral blood of patients with solid tumors. Blood 83: 636-640
6. Bucher M, Manegold C, Krempien B and Drings P (1994) Immunocytological staining with HEA-125 on bone marrow aspirates for staging small cell lung cancer (SCLC). Ann Oncol 5: P820 (Abstract 163)
7. Carbone DP, Koros AMC, Linnoila I, Jewett P and Gazdar AF (1991) Neural cell adhesion molecule expression and messenger RNA splicing patterns in lung cancer cell lines are correlated with neuroendocrine phenoytype and growth morphology. Cancer Res 51: 6142-6149
8. Cox DR (1972) Regression models and life tables. J R Stat Soc 34: 187-202
9. Cunningham A, Hemperly JJ, Murray BA, Pridiger EA, Brackenbury R and Edelman GM (1987) Neural cell adhesion molecule: structure, immunoglobulin like domains, cell surface modulation and alternative RNA splicing. Science 236: 799-806
10. Dalseg AM, Linnemann D and Bock E (1989) Soluble neural cell adhesion molecule in brain, cerebrospinal fluid and plasma in the developing rat. Int J Devl Neuroscience 7: 209-217
11. Davidoff MS, Schulze W and Holstein AF (1991) Combination of alkaline phosphatase anti-alkaline-phosphatase (APAAP)-and avidin-biotin-alkaline phosphatase complex (ABAP)-techniques for amplification of immunocytochemical staining of human testicular tissue. Andrologia 23: 353-356
12. Doyle LA, Borges M, Hussain A, Elias A and Tomiyasu T (1990) An adherent subline of a unique small-cell lung cancer cell line downregulates antigens of the neural cell adhesion molecule. J Clin Invest 86: 1818-1854
13. Elias AD (1997) Small cell lung cancer. State-of-the-art therapy in 1996. Chest 112: 251S-258S
14. Everard MJ, Macaulay VM, Min T, Millar JL and Smith IE (1990) Small cell lung cancer cell line from histologically and immunocytochemically negative bone marrow. Eur J Cancer 26: 766-767
15. Frew AJ, Ralfkiaer N, Ghosh AK, Gatter KC and Mason DY (1986) Immunocytochemistry in the detection of bone marrow metastases in patients with primary lung cancer. Br J Cancer 53: 555-556
16. Hay FG, Ford A and Leonard RCF (1988) Clinical applications of immunocytochemistry in the monitoring of the bone marrow in small cell lung cancer (SCLC). Int J Cancer; 8-10
17. Hirano T, Hirohashi S, Kunii T, Noguchi M and Shimosato Y (1989) Quantitative distribution of cluster 1 small cell lung cancer antigen in cancerous and non-cancerous tissues, cultured cells and sera. Jpn J Cancer Res 80: 348-355
18. Hirsch FR and Hansen HH (1980) Bone marrow involvement in small cell anaplastic carcinoma of the lung. Prognostic and therapeutic aspects. Cancer 46: 206-211
19. Hunter RF, Broadway P, Sun S, Niell HB and Mauer AM (1987) Detection of small cell lung cancer bone marrow involvement by discontinuous gradient sedimentation. Cancer Res 47: 2727-2740
20. Kaplan EL and Meier P (1958) Nonparametric estimation from incomplete observations. Am Stat Assoc J 53: 457-481
21. Keilhauer GA, Faissner A and Schachner M (1985) Differential inhibition of neurone neurone, neurone - astrocyte and astrocyte - astrocyte adhesion by L1, L2 and NCAM antibodies. Nature 316: 728-730
22. Kelly BW, Morris JF, Harwood BP and Bruya TE (1984) Methods and therapeutic value of bone marrow examination in small cell carcinoma of the lung. Cancer 53: 99-102
23. Kern WF, Spier CM, Hanneman EH, Miller TP, Matzner M and Grogan TM (1992) Neural cell adhesion molecule-positive peripheral T-cell lymphoma: a rare variant with a propensity for unusual sites of involvement. Blood 79: 2432-2437
24. Komminoth P, Roth J, Lackie PM, Bitter-Suermann D and Heitz PU (1991) Polysialic acid of the neural cell adhesion molecule distinguishes small cell lung carcinoma from carcinoids. Am J Pathol 139: 297-304
25. Lanier LL, Spits H and Phillips JH (1992) The developmental relationship between NK cells and T cells. Immunol Today 13: 392-395
26. Ledermann JA, Pasini F, Olabiran Y and Pelosi G (1994) Detection of neural cell adhesion molecule (NCAM) in serum of patients with small cell lung cancer (SCLC) with "limited" or "extensive" disease, and bone marrow infiltration. Int J Cancer 8: 49-52
27. Leonard RCF, Duncan LW and Hay FG (1990) Immunocytological detection of residual marrow disease at clinical remission predicts metastatic relapse in small cell lung cancer. Cancer Res 50: 6545-6548
28. Mantel N and Haenszel W (1959) Statistical aspects of the analysis of data from retrospective studies of disease. J Natl Cancer Inst 22: 719-748
29. Menard S, Porro G, Giani S, Bedini A, Bidoli P, Santoro A, Bregni M, Gianni AM, Pilotti S, Rilke F, Soresi S, Fasolato S and Colnaghi MI (1988) Detection of SCLC metastatic cells in bone marrow by means of the monoclonal antibody MLuCI. Lung Cancer 4: 73-75
30. Miettinen M and Cupo W (1993) Neural cell adhesion molecule distribution in soft tissue tumors. Hum Pathol 24: 62-66
31. Molino A, Colombatti M, Bonetti F, Zardini M, Pasini F, Perini A, Pelosi G, Tridente G, Veneri D and Cetto GL (1991) A comparative analysis of three different techniques for the detection of breast cancer cells in bone marrow. Cancer 67: 1033-1036
32. Moolenaar CECK, Muller EJ, Schol DJ, Figdor CG, Bock E, Bitter-Suermann D and Michalides RJAM (1990) Expression of neural cell adhesion molecule-related sialoglycoprotein in small cell lung cancer and neuroblastoma cell line H69 and CHP-212. Cancer Res 50: 1102-1106
33. Moolenaar CECK, Pieneman C, Walsh FS, Mooi WJ and Michalides RJAM (1992) Alternative splicing of neural cell adhesion molecule mRNA in human small cell lung cancer cell line H69. Int J Cancer 51: 238-243
34. Moss F, Bobrow L, Beverley P and Souhami R (1988) Detection of small cell carcinoma in bone marrow aspirates using monoclonal antibodies and mixtures of monoclonal antibodies. Lung Cancer 4; 76-78
35. Myklebust AT, Godal A, Pharo A, Juell S and Fodstad Ø (1993a) Eradication of small cell lung cancer cells from human bone marrow with immunotoxins. Cancer Res 53: 3784-3788
36. Myklebust AT, Pharo A and Fodstad Ø (1993b) Effective removal of SCLC from human bone marrow. Use of four monoclonal antibodies and immunomagnetic beads. Br J Cancer 67: 1331-1336
37. Nakamura S, Suchi T, Koshikawa T, Kitoh K, Koike K, Komatsu H, Iida S, Kagami Y, Ogura M, Katoh E, Kurita S, Suzuki H, Kobashi Y, Yamabe H, Hirabayashi N, Ueda R and Takahashi T (1995) Clinicopathologic study of CD56 (NCAM)-positive angiocentric lymphoma occurring in sites other than the upper and lower respiratory tract. Am J Surg Pathol 19: 284-296
38. Pasini F, Pelosi G, Ledermann JA and Cetto GL (1994a) Detection of small-cell-lung-cancer cells in bone marrow aspirates by monoclonal antibodies NCC-LU 243, NCC-LU-246 and MluC1. Int J Cancer 53-56
39. Pasini F, Pelosi G, Pavanel F, Sabbioni R, Oliani C, Mostacci R, Masotti A, Spagnoli P, Recaldin E & Cetto GL (1994b) Monoclonal antibodies improve the detection of bone marrow metastasis in bone marrow aspirates (BMA) of patients with small cell lung cancer (SCLC) and contribute to identify patients with better prognosis. Ann Oncol 5: O808 (Abstr), 161
40. Pasini F, Pelosi G, Mostacci R, Santo A, Masotti A, Spagnolli P, Recaldin E and Cetto GL (1995) Detection at diagnosis of tumor cells in bone marrow aspirates of patients with small cell lung cancer and clinical correlations. Ann Oncol 6: 86-88
41. Pasini F, Pelosi G, Verlato G, Guidi G, Pavanel F, Tummarello D, Masotti A and Cetto GL (1998) Positive immunostaining with MLuC1 of bone marrow aspirate predicts poor outcome in patients with small-cell lung cancer. Ann Oncol 9: 181-185
42. Patel K, Frost G, Kiely F, Phimister E, Coakham HB and Kemshead JT (1991) Expression of the cluster 1 antigen (neural cell adhesion molecule) in neuroectodermal tumours. Br J Cancer 63: 20-23
43. Patel K, Moore SE, Dickson G, Rossell RJ, Beverley PC, Kemshed JT and Walsh FS (1989) Neural cell adhesion molecule (NCAM) is the antigen recognized by monoclonal antibodies of similar specificity in small cell lung carcinoma and neuroblastoma. Int J Cancer 44: 573-578
44. Patriarca C, Pruneri G, Alfano MR, Carboni N, Ermellino L, Guddo F, Buffa R, Siccardi AG and Coggi G (1997) Polysialylated N-CAM, chromogranin A and B, and secretogranin II in neuroendocrine tumours of the lung. Virchows Arch 430: 455-460
45. Pelosi G, Molino AM, Pavanel F, Turazza M and Cetto GL (1997) Immunodetection of breast cancer cells in bone marrow for monitoring high-dose sequential chemotherapy. Appl Immunohistochem 5: 67-70
46. Pelosi G, Pasini F, Pavanel F, Bresaola E, Schiavon I and Iannucci A (1999) Effects of different immunolabeling techniques on the detection of small cell lung cancer cells in bone marrow. J Histochem Cytochem (in press)
47. Perez EA, Loprinzi CL, Sloan JA, Owens DT, Novotny PJ and Bonner JA (1997) Utility of screening procedures for detecting recurrence of disease after complete response in patients with small cell lung carcinoma. Cancer 80: 676-680
48. Pollard EB, Tio F, Myers JW, Clark G, Coltman CA and von Hoff D (1981) Utilization of a human tumor cloning system to monitor for marrow involvement with small cell carcinoma of the lung. Cancer Res 41: 1015-1020
49. Pollerberg GE, Schachner M and Davoust J (1986) Differentiation-state dependent surface mobilities of two forms of the neural cell adhesion molecule. Nature 234: 462-465
50. Ross AA, Cooper BW, Lazarus HM, Mackay W, Moss TJ, Ciobanu N, Tallman MS, Kennedy MJ, Davidson NE, Sweet D, Winter C, Akard L, Jansen J, Copelman E, Meagher RC, Herzig RH, Klumpp TR, Kahn DG and Warner NE (1993) Detection and viability of tumor cells in peripheral blood stem cell collections from breast cancer patients using immunocytochemical and clonogenic assay techniques. Blood 82: 2605-2610
51. Rutishauer U, Acheson A, Hall AK, Mann DM and Sunshine J (1988) The neural cell adhesion molecule (N-CAM) as a regulator of cell - cell interactions. Science 240: 53-57
52. Skov BG, Hirsh FR and Bobrow L (1992) Monoclonal antibodies in the detection of bone marrow metastases in small cell lung cancer. Br J Cancer 65: 593-596
53. Stahel RA, Gilks WR, Lehmann H and Schenker T (1994) Third international workshop on lung tumor and differentiation antigens: overview of the results of the central data analysis. Int J Cancer 8: 6-26
54. Stahel RA, Mabry M, Skarin AT, Speak J and Bernal SD (1985) Detection of bone marrow metastasis in small cell lung cancer by monoclonal antibody. J Clin Oncol 3: 455-461
55. Tome Y, Hirohashi S, Noguchi M, Matsuno Y, Kishi K, Uei Y and Shimosato Y (1991) Immunocytologic diagnosis of small-cell lung cancer in imprint smears. Acta Cytol 35: 485-490
56. Trillet V, Revel D, Combaret V, Favrot M, Loire R, Tabib A, Pages J, Jacquemet P, Bonmartin A, Mornex JF, Cordier JF, Pinet F, Amiel M and Brune J (1989) Bone marrow metastases in small cell lung cancer: detection with magnetic resonance imaging and monoclonal antibodies. Br J Cancer 60: 83-88