Comparison between MRI, microbiology and histology in evaluation of antibiotics in a murine model of thigh infection

Magnetic Resonance Materials in Physics, Biology and Medicine

Volumn 9, Issue 1-2, 1999, Pages 21-28

  Marzola, P ^a   Nicolato, E ^a   Di Modugno, E ^b   Cristofori, P ^b   Lanzoni, A ^b   Ladel, C H ^b   Sbarbati, A ^a  

^a Univ V   (Italy)

^b GLAXOSMITHKLINE   (United States)

Author keywords

Antibiotics; Mouse; MRI; Pharmacological research; Staphylococcus aureus; Thigh infection

Indexed keywords

ANTIBIOTIC AGENT; CILASTATIN PLUS IMIPENEM; VANCOMYCIN;

ACCURACY; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BACTERIOLOGY; CONTROLLED STUDY; DRUG EFFICACY; DRUG RESEARCH; DRUG SCREENING; HISTOPATHOLOGY; IN VIVO STUDY; INTERMETHOD COMPARISON; MALE; MOUSE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; PRIORITY JOURNAL; STAPHYLOCOCCUS AUREUS; STAPHYLOCOCCUS INFECTION; THIGH;

ANIMALS; ANTI-BACTERIAL AGENTS; BACTERIOLOGICAL TECHNIQUES; CILASTATIN; DISEASE MODELS, ANIMAL; DRUG EVALUATION, PRECLINICAL; DRUG THERAPY, COMBINATION; EVALUATION STUDIES; EXTREMITIES; HISTOLOGICAL TECHNIQUES; IMIPENEM; MAGNETIC RESONANCE IMAGING; MALE; MICE; MICE, INBRED ICR; MICROBIAL SENSITIVITY TESTS; STAPHYLOCOCCAL INFECTIONS; STAPHYLOCOCCUS AUREUS; VANCOMYCIN;

EID: 0032738207     PISSN: 13528661     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1352-8661(99)00037-X     Document Type: Article

References (15)

1. Rudin M., Beckmann N., Mir A., Sauter A. In vivo magnetic resonance imaging and spectroscopy in pharmacological research: assessment of morphological, physiological and metabolic effects of drugs. Eur. J. Pharm. Sci. 3:1995;255-264.
2. Rudin M., Briner U., Doepfner W. Quantitative magnetic resonance imaging of estradiol-induced pituitary hyperplasia in rats. Magn. Reson. Med. 7:1998;285-291.
3. Umemura K., Zierhut W., Rudin M., Novosel D., Robertson E., Pedersen B., Hof R.P. Effect of Spirapil on left ventricular hypertrophy due to volume overload in rats. J. Cardiovasc. Pharmacol. 19:1992;375-381.
4. Cook N.S., Zerwes H.G., Pally C., Rudin M., Hof R.P. Spirapril and cilazapril inhibit neointimal lesion development but cause no detectable inhibition of lumen narrowing after carotid artery balloon catheter injury in the rat. Blood Press. 2:1993;311-322.
5. Beckmann N., Bruttel K., Mir A., Rudin M. Noninvasive 3D MR microscopy as a tool in pharmacological research: application to a model of rheumatoid arthritis. Magn. Reson. Imag. 3(7):1995;1013-1017.
6. Minematsu K., Fisher M., Li L., Sotak C.H. Diffusion and perfusion magnetic resonance imaging studies to evaluate a noncompetitive N-Methyl-D-Aspartate antagonist and reperfusion in experimental stroke in rats. Stroke. 24:1993;2074-2081.
7. Minematsu K., Fisher M., Li L., Davis M.A., Knapp A.G., Cotter R.E., McBurney R.N., Sotak C.H. Effects of a novel NMDA antagonist on experimental stroke rapidly and quantitatively assessed by diffusion-weighted MRI. Neurology. 43:1993;397-403.
8. Tatlisumak T., Carano R.A.D., Takano K., Opgenorth T.J., Sotak C.H., Fisher M. A novel endothelin antagonist, A-127722, attenuates ischemic lesion size in rats with temporary middle cerebral artery occlusion-A diffusion and perfusion study. Stroke. 29:1998;850-858.
9. Acred P. The Selbie or Thigh Lesion Test, Experimental Models in Antimicrobial Chemotherapy, vol. I. London: Academic Press, 1986.
10. Eng R.H., Cherubin C.E., Smith S.M., Buccini F., Harris R. In-vitro and in-vivo activity of cefpirone (HR 810) against methicillin-susceptible and -resistant Staphylococcus aureus and Streptococcus faecalis. J. Antimicrob. Chemoth. 23:1989;373-381.
11. Shirkhoda A., Ali-Reza A., Bis K.G., Makris J., Irwin R.B., Shetty A.N. MR Imaging of myositis ossificans: variable patterns at different stages. J. Magn. Reson. Imag. 5:1995;287-292.
12. National Committee for Clinical Laboratory Standard. Methods for dilution anti-microbial susceptibility tests for bacteria that grow aerobically. 4th ed. Villanova, Pa: Approved Standard M7-A4. National Committee for Clinical Laboratory Standards, 1997.
13. Marzola P, Da Pra A, Sbarbati A, Osculati F. A PC-based workstation for processing and analysis of MRI data, MAG*MA, in press.
14. Craig W.A. Interrelationship between pharmacokinetics and pharmacodinamics in determing dose regimens for broad spectrum cephalosporins. Diagn. Microbiol. Inf. Dis. 22:1995;89-96.
15. Selbie F.R., O'Grady F. A measurable tubercolous lesion in the thigh of the mouse. Br. J. Exp. Pathol. 35:1954;556-565.