Maitotoxin-induced phosphoinositide hydrolysis is dependent on extracellular but not intracellular Ca2+ in human astrocytoma cells

Japanese Journal of Pharmacology

Volumn 81, Issue 2, 1999, Pages 240-243

  Nakahata, Norimichi ^a   Yaginuma, Toshiko ^a   Ohizumi, Yasushi ^a  

^a TOHOKU UNIVERSITY   (Japan)

Author keywords

Ca2+; Maitotoxin; Phosphoinositide hydrolysis

Indexed keywords

CALCIUM ION; EGTAZIC ACID; ETHYLENE GLYCOL 1,2 BIS(2 AMINOPHENYL) ETHER N,N,N',N' TETRAACETIC ACID; INOSITOL; INOSITOL 1,4,5 TRISPHOSPHATE; MAITOTOXIN; PHOSPHATIDYLINOSITIDE;

ARTICLE; ASTROCYTOMA CELL; CALCIUM CELL LEVEL; CONCENTRATION RESPONSE; CONTROLLED STUDY; DOSE TIME EFFECT RELATION; EXTRACELLULAR CALCIUM; HUMAN; HUMAN CELL; HYDROLYSIS; ISOTOPE LABELING; PHOSPHOINOSITIDE METABOLISM;

ASTROCYTOMA; BRAIN NEOPLASMS; CALCIMYCIN; CALCIUM; CHELATING AGENTS; EGTAZIC ACID; EXTRACELLULAR SPACE; HUMANS; HYDROLYSIS; INOSITOL 1,4,5-TRISPHOSPHATE; IONOPHORES; MARINE TOXINS; OXOCINS; PHOSPHATIDYLINOSITOLS; TUMOR CELLS, CULTURED;

EID: 0032738137     PISSN: 00215198     EISSN: None     Source Type: Journal    
DOI: 10.1254/jjp.81.240     Document Type: Article

References (15)

1. Gusovsky F and Daly JW: Maitotoxin: a unique pharmacological tool for research on calcium-dependent mechanisms. Biochem Pharmacol 39, 1633-1639 (1990)
2. Ohizumi Y: Application of physiologically active substances isolated from natural resources to pharmacological studies. Jpn J Pharmacol 73, 263-289 (1997)
3. Estacion M, Nguyen HB and Gargus JJ: Calcium is permeable through a maitotoxin-activated nonselective cation channel in mouse L cells. Am J Physiol 270, C1145-C1152 (1996)
4. Bielfeldackermann A, Range C and Kormacher C: Maitotoxin (MTX) activates a nonselective cation channel in Xenopus laevis oocytes. Pflugers Arch Eur J Physiol 436, 329-337 (1998)
5. Berta P, Sladeczek F, Derancourt J, Durand M, Travo P and Maiech J: Maitotoxin stimulates the formation of inositol phosphates in rat aortic myocytes. FEBS Lett 197, 349-352 (1986)
6. Gusovsky F, Lueders JE, Kohn EC and Felder CC: Muscarinic receptor-mediated tyrosine phosphorylation of phospholipase C-γ. J Biol Chem 268, 7768-7772 (1993)
7. Soergel DG, Yasumoto T, Daly JW and Gusovsky F: Maitotoxin effects are blocked by SK&F 96365, an inhibitor of receptor-mediated calcium entry. Mol Pharmacol 41, 487-493 (1992)
8. Venant A, Dazy AC, Diogene G, Metezeau P and Marano F: Effects of maitotoxin on calcium entry and phosphoinositide breakdown in rabbit ciliated tracheal epithelium. Biol Cell 82, 195-202 (1994)
9. Ishimoto H, Matsuoka I, Nakanishi H and Nakahata N: A comparative study of arachidonic acid metabolism in rabbit cultured astrocytes and human astrocytoma cells (1321N1). Gen Pharmacol 27, 313-317 (1996)
10. 2 receptor in 1321N1 human astrocytoma cells. J Pharmacol Exp Ther 276, 829-836 (1996)
11. Nakahata N, Abe MT, Matsuoka I and Nakanishi H: Mastoparan inhibits phosphoinositide hydrolysis via pertussis toxin-insensitive G-protein in human astrocytoma cells. FEBS Lett 260, 91-94 (1990)
12. 2+ concentration in human astrocytoma cells. Br J Pharmacol 112, 299-303 (1994)
13. Bradford MM: A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 73, 248-254 (1976)
14. Gusovsky F, Yasumoto T and Daly JW: Calcium-dependent effects of maitotoxin on phosphoinositide breakdown and on cyclic AMP accumulation in PC12 and NCB-20 cells. Mol Pharmacol 36, 44-53 (1989)
15. Bressler JP, Belloni-Olivi L and Forman S: Effect of ganglioside GM1 on arachidonic acid release in bovine aortic endothelial cells. Life Sci 54, 49-60 (1994)