메뉴 건너뛰기




Volumn 76, Issue 6, 1999, Pages 362-373

Morphine metabolism in the pregnant guinea pig and her pups

Author keywords

Chronic morphine exposure; Developmental pharmacokinetics; Morphine pharmacokinetics; Morphine 3 glucuronide; Morphine 6 glucuronide

Indexed keywords

DIAMORPHINE; LIVER ENZYME; MORPHINE; MORPHINE 3 GLUCURONIDE; MORPHINE 6 GLUCURONIDE; OPIATE;

EID: 0032737599     PISSN: 00063126     EISSN: None     Source Type: Journal    
DOI: 10.1159/000014180     Document Type: Article
Times cited : (6)

References (51)
  • 2
    • 0000385967 scopus 로고
    • The pharmacologic implications of the fate of morphine and its surrogates
    • Way EL, Adler TK: The pharmacologic implications of the fate of morphine and its surrogates. Pharmacol Rev 1960;12:383-445.
    • (1960) Pharmacol Rev , vol.12 , pp. 383-445
    • Way, E.L.1    Adler, T.K.2
  • 3
    • 0024591718 scopus 로고
    • Placental permeability for morphine-3-β-D-glucuronide in the guinea pig
    • Olsen GD, Norris SR, Sommer KM, Grosso SM: Placental permeability for morphine-3-β-D-glucuronide in the guinea pig. Placenta 1989;10: 83-93.
    • (1989) Placenta , vol.10 , pp. 83-93
    • Olsen, G.D.1    Norris, S.R.2    Sommer, K.M.3    Grosso, S.M.4
  • 4
    • 0028171129 scopus 로고
    • Diffusion of morphine-6-β-D-glucuronide into the neonatal guinea pig brain during drug-induced respiratory depression
    • Murphy LJ, Olsen GD: Diffusion of morphine-6-β-D-glucuronide into the neonatal guinea pig brain during drug-induced respiratory depression. J Pharmacol Exp Ther 1994; 271:118-124.
    • (1994) J Pharmacol Exp Ther , vol.271 , pp. 118-124
    • Murphy, L.J.1    Olsen, G.D.2
  • 5
    • 0027304846 scopus 로고
    • A stereospecific microassay for the determination of morphine-6-β-D-glucuronide and other active morphine metabolites in the neonatal guinea pig
    • Murphy LJ, Olsen GD: A stereospecific microassay for the determination of morphine-6-β-D-glucuronide and other active morphine metabolites in the neonatal guinea pig. L Liquid Chromatogr 1993;16:2545-2561.
    • (1993) L Liquid Chromatogr , vol.16 , pp. 2545-2561
    • Murphy, L.J.1    Olsen, G.D.2
  • 6
    • 0026059585 scopus 로고
    • Antinociceptive and ventilatory effects of the morphine metabolites: Morphine-6-glucuronide and morphine-3-glucuronide
    • Gong QL, Hedner T, Hedner J, Björkman R, Nordberg G: Antinociceptive and ventilatory effects of the morphine metabolites: Morphine-6-glucuronide and morphine-3-glucuronide. Eur J Pharmacol 1991;193: 47-56.
    • (1991) Eur J Pharmacol , vol.193 , pp. 47-56
    • Gong, Q.L.1    Hedner, T.2    Hedner, J.3    Björkman, R.4    Nordberg, G.5
  • 8
    • 0027958222 scopus 로고
    • Morphine-6-β-D-glucuronide respiratory pharmacodynamics in the neonatal guinea pig
    • Murphy LJ, Olsen GD: Morphine-6-β-D-glucuronide respiratory pharmacodynamics in the neonatal guinea pig. J Pharmacol Exp Ther 1994; 268:110-116.
    • (1994) J Pharmacol Exp Ther , vol.268 , pp. 110-116
    • Murphy, L.J.1    Olsen, G.D.2
  • 9
    • 0344336886 scopus 로고
    • Plasma levels, urinary and fecal excretion of morphine in non-tolerant and tolerant dogs
    • Cochin J, Haggart J, Woods LA, Seevers MH: Plasma levels, urinary and fecal excretion of morphine in non-tolerant and tolerant dogs. J Pharmacol Exp Ther 1954;111:74-83.
    • (1954) J Pharmacol Exp Ther , vol.111 , pp. 74-83
    • Cochin, J.1    Haggart, J.2    Woods, L.A.3    Seevers, M.H.4
  • 10
    • 0345199445 scopus 로고
    • The distribution and fate of morphine in the non-tolerant and tolerant monkey
    • Mellett LB, Woods LA: The distribution and fate of morphine in the non-tolerant and tolerant monkey. J Pharmacol Exp Ther 1956;116:77-83.
    • (1956) J Pharmacol Exp Ther , vol.116 , pp. 77-83
    • Mellett, L.B.1    Woods, L.A.2
  • 11
    • 0000754086 scopus 로고
    • Distribution and fate of morphine in non-tolerant and tolerant dogs and rats
    • Woods LA: Distribution and fate of morphine in non-tolerant and tolerant dogs and rats. J Pharmacol Exp Ther 1954;112:158-175.
    • (1954) J Pharmacol Exp Ther , vol.112 , pp. 158-175
    • Woods, L.A.1
  • 12
    • 0345199444 scopus 로고
    • The effect of prolonged morphine administration on the in vivo and in vitro conjugation of morphine by rats
    • Zauder HL: The effect of prolonged morphine administration on the in vivo and in vitro conjugation of morphine by rats. J Pharmacol Exp Ther 1952;104:11-19.
    • (1952) J Pharmacol Exp Ther , vol.104 , pp. 11-19
    • Zauder, H.L.1
  • 13
    • 0344768871 scopus 로고
    • Concentration of free and conjugated morphine in brain and other tissues of tolerant and nontolerant rabbits
    • Siminoff R, Saunders PR: Concentration of free and conjugated morphine in brain and other tissues of tolerant and nontolerant rabbits. J Pharmacol Exp Ther 1958;124:252-254.
    • (1958) J Pharmacol Exp Ther , vol.124 , pp. 252-254
    • Siminoff, R.1    Saunders, P.R.2
  • 15
    • 0345199443 scopus 로고
    • Studies on glucuronide synthesis in rats chronically treated with morphine and phenol
    • Takemori AE, Glowacki GA: Studies on glucuronide synthesis in rats chronically treated with morphine and phenol. Biochem Pharmacol 1962;11:867-870.
    • (1962) Biochem Pharmacol , vol.11 , pp. 867-870
    • Takemori, A.E.1    Glowacki, G.A.2
  • 16
    • 0345199442 scopus 로고
    • Determination of in vitro disappearance of added morphine effected by minced tissues of morphine-tolerant rats during withdrawal
    • Deneau GA, Woods LA, Seevers MH: Determination of in vitro disappearance of added morphine effected by minced tissues of morphine-tolerant rats during withdrawal. Fed Proc 1953;12:315.
    • (1953) Fed Proc , vol.12 , pp. 315
    • Deneau, G.A.1    Woods, L.A.2    Seevers, M.H.3
  • 17
    • 0344336885 scopus 로고
    • The effect of adrenalectomy on the development of tolerance to morphine and methadone
    • Way EL, Sung CY, Fujimoto JM: The effect of adrenalectomy on the development of tolerance to morphine and methadone. J Pharmacol Exp Ther 1954;110:51.
    • (1954) J Pharmacol Exp Ther , vol.110 , pp. 51
    • Way, E.L.1    Sung, C.Y.2    Fujimoto, J.M.3
  • 21
    • 0030373234 scopus 로고    scopus 로고
    • Patient-controlled analgesia for mucositis pain in children: A three-period crossover study comparing morphine and hydromorphone
    • Collins JJ, Geake J, Grier HE. Houck CS, Thaler HT, Weinstein HJ, Twum-Danso NY, Berde CB: Patient-controlled analgesia for mucositis pain in children: A three-period crossover study comparing morphine and hydromorphone. J Pediatr 1996;129:722-728.
    • (1996) J Pediatr , vol.129 , pp. 722-728
    • Collins, J.J.1    Geake, J.2    Grier, H.E.3    Houck, C.S.4    Thaler, H.T.5    Weinstein, H.J.6    Twum-Danso, N.Y.7    Berde, C.B.8
  • 22
    • 0029968866 scopus 로고    scopus 로고
    • Rectal administration of morphine in children. Pharmacokinetic evaluation after a single dose
    • Lundeberg S, Beck O, Olsson GL, Boreus LO: Rectal administration of morphine in children. Pharmacokinetic evaluation after a single dose. Acta Anaesthesiol Scand 1996;40: 445-451.
    • (1996) Acta Anaesthesiol Scand , vol.40 , pp. 445-451
    • Lundeberg, S.1    Beck, O.2    Olsson, G.L.3    Boreus, L.O.4
  • 23
    • 18244420645 scopus 로고
    • Vascular pressure-volume relationships in pregnant and estrogen-treated guinea pigs
    • Davis LE, Hohimer AR, Giraud GD, Paul MS, Morton MJ: Vascular pressure-volume relationships in pregnant and estrogen-treated guinea pigs. Am J Physiol 1989;257: R1205-R1211.
    • (1989) Am J Physiol , vol.257
    • Davis, L.E.1    Hohimer, A.R.2    Giraud, G.D.3    Paul, M.S.4    Morton, M.J.5
  • 27
    • 0029846071 scopus 로고    scopus 로고
    • Pharmacokinetics of morphine and its glucuronides after intravenous infusion of morphine and morphine-6-glucuronide in healthy volunteers
    • Lötsch J, Stockmann A, Kobal G, Brune K, Waibel R, Schmidt N, Geisslinger G: Pharmacokinetics of morphine and its glucuronides after intravenous infusion of morphine and morphine-6-glucuronide in healthy volunteers. Clin Pharmacol Ther 1996;60:316-325.
    • (1996) Clin Pharmacol Ther , vol.60 , pp. 316-325
    • Lötsch, J.1    Stockmann, A.2    Kobal, G.3    Brune, K.4    Waibel, R.5    Schmidt, N.6    Geisslinger, G.7
  • 31
    • 0025190756 scopus 로고
    • Morphine and metabolite behavior after different routes of morphine administration: Demonstration of the importance of the active metabolite morphine-6-glucuronide
    • Osborne R, Joel S, Trew D, Slevin M: Morphine and metabolite behavior after different routes of morphine administration: Demonstration of the importance of the active metabolite morphine-6-glucuronide. Clin Pharmacol Ther 1990;47: 12-19.
    • (1990) Clin Pharmacol Ther , vol.47 , pp. 12-19
    • Osborne, R.1    Joel, S.2    Trew, D.3    Slevin, M.4
  • 34
    • 0022658532 scopus 로고
    • Maternal-fetal distribution of morphine and alfentanil in near-term sheep and rhesus monkeys
    • Golub MS, Eisele JH, Anderson JH: Maternal-fetal distribution of morphine and alfentanil in near-term sheep and rhesus monkeys. Dev Pharmacol Ther 1986;9:12-22.
    • (1986) Dev Pharmacol Ther , vol.9 , pp. 12-22
    • Golub, M.S.1    Eisele, J.H.2    Anderson, J.H.3
  • 35
    • 0020929527 scopus 로고
    • A physiological pharmacokinetic model of morphine disposition in the pregnant rat
    • Gabrielsson JL, Paalzow LK: A physiological pharmacokinetic model of morphine disposition in the pregnant rat. J Pharmacokinet Biopharm 1983;11:147-163.
    • (1983) J Pharmacokinet Biopharm , vol.11 , pp. 147-163
    • Gabrielsson, J.L.1    Paalzow, L.K.2
  • 37
    • 0027536615 scopus 로고
    • Uptake, 3-and 6-glucuronidation of morphine in isolated cells from stomach, intestine, colon, and liver of the guinea pig
    • Dechelotte P, Sabouraud A, Sandouk P, Hackbarth I, Schwenk M: Uptake, 3-and 6-glucuronidation of morphine in isolated cells from stomach, intestine, colon, and liver of the guinea pig. Drug Metab Dispos 1993;21:13-17.
    • (1993) Drug Metab Dispos , vol.21 , pp. 13-17
    • Dechelotte, P.1    Sabouraud, A.2    Sandouk, P.3    Hackbarth, I.4    Schwenk, M.5
  • 38
    • 0020399236 scopus 로고
    • Alterations of NADPH-generating and drug-metabolizing enzymes by feed restriction in male rats
    • Sachen DS, Das SK: Alterations of NADPH-generating and drug-metabolizing enzymes by feed restriction in male rats. J Nutr 1982;112: 2301-2306.
    • (1982) J Nutr , vol.112 , pp. 2301-2306
    • Sachen, D.S.1    Das, S.K.2
  • 39
    • 0018974675 scopus 로고
    • Modification of hepatic drug metabolizing enzyme activities and their induction by dietary protein
    • Hietanen E: Modification of hepatic drug metabolizing enzyme activities and their induction by dietary protein. Gen Pharmacol 1980;11:443-450.
    • (1980) Gen Pharmacol , vol.11 , pp. 443-450
    • Hietanen, E.1
  • 40
    • 0028796027 scopus 로고
    • Membrane translocation and regulation of uridine diphosphate-glucuronic acid uptake in rat liver microsomal vesicles
    • Berg CL, Radominska A, Lester R, Gollan JL: Membrane translocation and regulation of uridine diphosphate-glucuronic acid uptake in rat liver microsomal vesicles. Gastroenterology 1995;108:183-192.
    • (1995) Gastroenterology , vol.108 , pp. 183-192
    • Berg, C.L.1    Radominska, A.2    Lester, R.3    Gollan, J.L.4
  • 43
    • 0027224052 scopus 로고
    • Pharmacokinetics of morphine infusion in premature neonates
    • Hartley R, Green M, Quinn M, Levene MI: Pharmacokinetics of morphine infusion in premature neonates. Arch Dis Child 1993;69:55-58.
    • (1993) Arch Dis Child , vol.69 , pp. 55-58
    • Hartley, R.1    Green, M.2    Quinn, M.3    Levene, M.I.4
  • 45
    • 0026603119 scopus 로고
    • Pharmacokinetic-pharmacodynamic relationship of morphine in neonates
    • Chay PCW, Duffy BJ, Walker JS: Pharmacokinetic-pharmacodynamic relationship of morphine in neonates. Clin Pharmacol Ther 1992;51:334-342.
    • (1992) Clin Pharmacol Ther , vol.51 , pp. 334-342
    • Chay, P.C.W.1    Duffy, B.J.2    Walker, J.S.3
  • 46
    • 0025179139 scopus 로고
    • Pharmacokinetics of a single dose of morphine in preterm infants during the first week of life
    • Bhat R, Chari G, Gulati A, Aldana O, Velamati R, Bhargava H: Pharmacokinetics of a single dose of morphine in preterm infants during the first week of life. J Pediatr 1990; 117:477-481.
    • (1990) J Pediatr , vol.117 , pp. 477-481
    • Bhat, R.1    Chari, G.2    Gulati, A.3    Aldana, O.4    Velamati, R.5    Bhargava, H.6
  • 47
    • 0023152905 scopus 로고
    • Morphine pharmacokinetics in early infancy
    • Lynn AM. Slattery JT: Morphine pharmacokinetics in early infancy. Anesthesiology 1987;66:136-139.
    • (1987) Anesthesiology , vol.66 , pp. 136-139
    • Lynn, A.M.1    Slattery, J.T.2
  • 50
    • 0028947152 scopus 로고
    • Intravenous morphine pharmacokinetics in pediatric patients with sickle cell disease
    • Dampier CD, Setty NY, Logan J, Ioli JG, Dean R: Intravenous morphine pharmacokinetics in pediatric patients with sickle cell disease. J Pediatr 1995;126:461-467.
    • (1995) J Pediatr , vol.126 , pp. 461-467
    • Dampier, C.D.1    Setty, N.Y.2    Logan, J.3    Ioli, J.G.4    Dean, R.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.