Synthesis and biological activity of aldose reductase inhibitors with Michael acceptor substituents

European Journal of Medicinal Chemistry

Volumn 34, Issue 3, 1999, Pages 235-243

  Donkor, Isaac O ^a   Abdel Ghany, Yasar S ^b   Kador, Peter F ^c   Mizoguchi, Tadashi ^c   Bartoszko Malik, Anita ^c   Miller, Duane D ^a  

^a UNIVERSITY OF TENNESSEE HEALTH SCIENCE CENTER   (United States)

^b OHIO STATE UNIVERSITY   (United States)

^c NATIONAL EYE INSTITUTE   (United States)

Author keywords

Aldehyde reductase; Aldose reductase; Alrestatin; Diabetic complications; Michael acceptors

Indexed keywords

2 FLUOROSPIRO[FLUORENE 9,4' IMIDAZOLIDINE] 2',5' DIONE; 5 ETHYLFUMARSMIDO 1,3 DIOXO 1H BENZ[D,E]ISOQUINOLINE 2(3H) ACETIC ACID; ALDOSE REDUCTASE INHIBITOR; ALRESTATIN; UNCLASSIFIED DRUG;

ARTICLE; DIABETES MELLITUS; DRUG CONFORMATION; DRUG EFFECT; DRUG SYNTHESIS; ENZYME INHIBITION; STRUCTURE ACTIVITY RELATION;

EID: 0032737043     PISSN: 02235234     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0223-5234(99)80056-7     Document Type: Article

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