DNA fragmentation precedes aberrant expression of cell cycle-related protein in rat brain after MCA occlusion

Neurological Research

Volumn 21, Issue 7, 1999, Pages 695-698

  Hayashi, Takeshi ^a   Sakurai, Masahiro ^a   Abe, Koji ^b   Itoyama, Yasuto ^a  

^a TOHOKU UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b OKAYAMA UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Apoptosis; Brain; Cell cycle; Cyclin; Cyclin dependent kinase; Infarct

Indexed keywords

CELL CYCLE PROTEIN; CYCLIN B1; CYCLIN D1; CYCLIN DEPENDENT KINASE; CYCLINE; DNA FRAGMENT;

ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BRAIN; CONTROLLED STUDY; IMMUNOBLOTTING; IMMUNOHISTOCHEMISTRY; MALE; MIDDLE CEREBRAL ARTERY OCCLUSION; NONHUMAN; PROTEIN EXPRESSION; RAT;

EID: 0032736977     PISSN: 01616412     EISSN: None     Source Type: Journal    
DOI: 10.1080/01616412.1999.11741000     Document Type: Article

References (17)

1. Charriaut-Marlangue C, Margaill I, Represa A, Popovici T, Plotkine M, Ben-Ari Y. Apoptosis and necrosis after reversible focal ischemia: An in situ DNA fragmentation analysis. J Cereb Blood Flow Metab 1996; 16: 186-194
2. Li Y, Chopp M, Jiang N, Yao F, Zaloga C. Temporal profile of in situ DNA fragmentation after transient middle cerebral artery occlusion in the rat. J Cereb Blood Flow Metab 1995; 15: 389-397
3. Asahi M, Hoshimaru M, Uemura Y, Tokime T, Kojima M, Ohtsuka T, Matsuura N, Aoki T, Shibahara K, Kikuchi H. Expression in interleukin-18 converting enzyme gene family and bcl-2 gene family in the rat brain following permanent occlusion of the middle cerebral artery. J Cereb Blood Flow Metab 1997; 17: 11-18
4. Heintz N. Cell death and the cell cycle: A relationship between transformation and neurodegeneration? TIBS 1993; 18: 157-159
5. Busser J, Geldmacher DS, Herrup K. Ectopic cell cycle proteins predict the sites of neuronal cell death in Alzheimer's disease brain. J Neurosci 1998; 18: 2801-2807
6. Liu W, Bi X, Tocco G, Baudry M, Schreiber SS. Increased expression of cyclin D1 in the adult rat brain following kainic acid treatment. NeuroReport 1996; 7: 2785-2789
7. Li Y, Chopp M, Powers C, Jiang N. Immunoreactivity of cyclin D1/ cdk4 in neurons and oligodendrocytes after focal cerebral ischemia in rat. I Cereb Blood flow Metab 1997; 17: 846-856
8. Hayashi T, Abe K, Suzuki H, Itoyama Y. Rapid induction of vascular endothelial growth factor gene expression after transient middle cerebral artery occlusion in rats. Stroke 1997; 28: 2039-2044
9. Hayashi T, Sakurai M, Abe K, Sadahiro M, Tabayashi K, Itoyama TY. Apoptosis of motor neurons with induction of caspases in the spinal cord after ischemia. Stroke 1998; 29: 1007-1013
10. Pines J. Cyclins and cyclin-dependent kinases: Take your partners. TIBS 1993; 18: 195-197
11. Pines J. Cyclins and cyclin-dependent kinases: A biochemical view. Biochem J 1995; 308: 697-711
12. Lee EYHP, Chang CY, Hu N, Wang YCJ, Lai CC, Herrup K, Lee WH, Bradley A. Mice deficient for Rb are nonviable and show defects in neurogenesis and haematopoiesis. Nature 1992; 359: 288-294
13. Xiong Y, Zhang H, Beach D. D type cyclins associate with multiple protein kinases and the DNA replication and repair factor PCNA. Cell 1992; 71: 504-514
14. Pines J, Hunter T. Human cyclins A and B1 are differentially located in the cell and undergo cell cycle-dependent nuclear transport. J Cell Biol 1991; 115: 1-17
15. Wiessner C, Brink I, Lopenz P, Neumann-Haefelin T, Vogel P, Yamashita K. Cyclin D1 messenger RNA is induced in microglia rather than neurons following transient forebrain ischemia. Neuroscience 1996; 72: 947-958
16. Meikrantz W, Gisselbrecht S, Tam SW, Schlegel R. Activation of cyclin A-dependent protein kinases during apoptosis. Proc Natl Acad Sci USA 1994; 91: 3754-3758
17. Park DS, Farinelli SE, Greene LA. Inhibitors of cyclin-dependent kinases promote survival of post-mitotic neuronally differentiated PC12 cells and sympathetic neurons. J Biol Chem 1996; 271: 8161-8169